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Essefi E.,University of Sfax | Touir J.,Harbin Institute of Technology | Tagorti M.A.,RU Genome | Tagorti M.A.,Higher Institute of Biotechnology of Monastir | Yaich C.,University of Sfax
Arabian Journal of Geosciences | Year: 2013

This study is meant to provide an insight into how discharge playas, which are strongly influenced by a regional salty groundwater flow regime, such as the discharge playa of Sidi El Hani, would respond to the climatic variability and to the materials coming from the subsurface of the Sahel area. In order to choose the appropriate method, a special care was given in this paper to different methods of investigation of the groundwater contribution in water and salt budgets of saline systems. The hydrogeological map of the surrounding aquifers proved their convergence toward Sidi El Hani discharge playa. As consequence of the dominance of a salty groundwater contribution, the climate variability may be considered minor. Accordingly, the model proposed by this study showed the dominance of the salty water coming from the hydrogeology at the expense of the fresh water coming from the climatic contribution. Moreover, according to the adopted model, the effect of the human-induced activity on the hydrogeological contribution such as the installation of dams in the Tunisian center and the overexploitation of the phreatic aquifer of Kairouan was judged increasing the convergence of Kairouan aquifer towards Sidi El Hani discharge playa. On the other hand, the consumption of salt reserves from the discharge playa tends to decrease its salinization. © 2012 Saudi Society for Geosciences.

Zidi I.,Higher Institute of Biotechnology of Monastir | Ben Amor N.,King Faisal University
Medical Hypotheses | Year: 2011

HLA-G, a very conserved non-classical class I human leukocyte antigen, is highly expressed in cancer pathologies. Recent evidences about HLA-G implication in immune tolerance announce the probable association between HLA-G and metastasis. We highlighted here possible mechanisms for link between HLA-G regulation and cascade metastasis including initiation, progression, and virulence steps. A thorough understanding of HLA-G implications in metastasis through future clinical studies, may probably lead to the improvement of cancer therapies and the limitation of relapses and metastasis. © 2011 Elsevier Ltd.

Marzouki H.,Laboratoire Of Botanique Et Of Biologie Vegetal | Khaldi A.,British Petroleum | Marongiu B.,University of Cagliari | Piras A.,University of Cagliari | Harzallah-Skhiri F.,Higher Institute of Biotechnology of Monastir
Natural Product Communications | Year: 2011

The compositions of the essential oils isolated from the aerial parts of tree Mediterranean populations of Laurus nobilis L. collected during the flowering phase on Tunisia, Algeria and France, were studied by GC and GC-MS. The analysis has allowed identifying 54 components. The main components were 1,8-cineole, α-terpinyl acetate (10-18.6%), methyl eugenol (10-22.1%), sabinene (1.2-8%), eugenol (1.2-11.7%) α-pinene (tr-4.5%) and β-pinene (0.4-4.2%). The monoterpene fraction was dominant in all the oils analysed and consisted mainly of oxygenated monoterpenes. The oils from the tree populations studied showed a clear chemical polymorphism. The principal component and the hierarchical cluster analyses separated the Laurus nobilis leaf essential oils into three groups.

Hlila M.B.,University of Monastir | Mosbah H.,Higher Institute of Biotechnology of Monastir | Mssada K.,Biotechnology Center | Jannet H.B.,University of Monastir | And 2 more authors.
Industrial Crops and Products | Year: 2015

The total phenolic, flavonoid and tannin contents of Scabiosa arenaria Forssk roots were determined by colorimetry. The in vitro antioxidant activity was characterized by varied assays like 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS), reducing power and β-carotene bleaching inhibition activity. The anti-acetylcholinesterase activity was also evaluated. Total phenolics and flavonoids contents were highest in the butanol fraction with 82.36mg gallic acid equivalents/g and 5.86mg quercetin/g of dry weight, respectively. This fraction exhibited an interesting antioxidant activity, mainly with the β-carotene bleaching inhibition test (IC50=0.018±0.009mg/mL). The same fraction showed the best anti-acetylcholinesterase activity (IC50=0.02±0.003mg/mL).The major phenolic compounds of the butanol extract were identified by RP-HPLC (reverse phase-high-performance liquid chromatography). A total of nine compounds were characterized, including p-coumaric acid, N-propyl gallate, myricetin and methyl-4-hydroxybenzoate. The active compounds identified and quantified in this fraction were mainly responsible for these in vitro biological activities. © 2015 .

Mtiraoui N.,University of Monastir | Mtiraoui N.,Higher Institute of Biotechnology of Monastir | Turki A.,University of Monastir | Nemr R.,University Medical Center Rizk Hospital | And 7 more authors.
Diabetes and Metabolism | Year: 2012

Background: While several type 2 diabetes mellitus (T2DM) susceptibility loci identified through genome-wide association studies (GWAS) have been replicated in many populations, their association in Arabs has not been reported. For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs. Methods: Study subjects (case/controls) were Lebanese (751/918) and Tunisians (1470/838). Genotyping was carried out by the allelic discrimination method. Results: In Lebanese and Tunisians, neither ENNP1 nor MLXIPL was associated with T2DM, whereas TCF7L2 was significantly associated with an increased risk of T2DM in both the Lebanese [P<0.001; OR (95% CI): 1.38 (1.20-1.59)] and Tunisians [P<0.001; OR (95% CI): 1.36 (1.18-1.56)]. Differential associations of IGF2BP2, KCNJ11, PPARγ and SLC30A8 with T2DM were noted in the two populations. IGF2BP2 [P=1.3×10-5; OR (95% CI): 1.66 (1.42-1.94)] and PPARγ [P=0.005; OR (95% CI): 1.41 (1.10-1.80)] were associated with T2DM in the Lebanese, but not Tunisians, while KCNJ11 [P=8.0×10-4; OR (95% CI): 1.27 (1.09-1.47)] and SLC30A8 [P=1.6×10-5; OR (95% CI): 1.37 (1.15-1.62)] were associated with T2DM in the Tunisians, but not Lebanese, after adjusting for gender and body mass index. Conclusion: T2DM susceptibility loci SNPs identified through GWAS showed differential associations with T2DM in two Arab populations, thus further confirming the ethnic contributions of these variants to T2DM susceptibility. © 2012 Elsevier Masson SAS.

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