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Bergkvist C.,Karolinska Institutet | Aune M.,National Food Administration | Nilsson I.,National Food Administration | Sandanger T.M.,University of Tromso | And 6 more authors.
Chemosphere | Year: 2012

In low-income countries, the use of some organochlorine pesticides is still common in order to increase food production. Monitoring the chemical exposure is an important step in risk-reducing strategies. This is the first study to report concentrations of organochlorines in breast milk of women from Bangladesh where farming is the main income source.Organochlorines such as p,. p'-DDT, o,. p'-DDT, p,. p'. -DDE, p,. p'. -DDD (i.e., ∑DDT), HCB, α-, β- and γ-HCH, trans-chlordane, cis-chlordane, oxy-chlordane, trans-nonachlor, cis-nonachlor, mirex and polychlorinated biphenyls (CB 28, 52, 99, 101, 105, 114, 118, 123, 128, 138, 141, 149, 153, 156, 157, 163, 167, 170, 180, 183, 187, 189, 194) were analyzed in breast milk collected in 2002 from 72 first-time mothers (median age 20. years) living in the rural area Matlab, Bangladesh.While the concentrations of PCBs and many of the pesticides were low, the concentrations of p,p'-DDT and its metabolite p,p'-DDE were high (median 349 and 1645ngg -1lipid, respectively) in comparison to other countries. The median value of ∑DDT was 2123ngg -1lipid. The estimated daily exposure to p,p'-DDT, p,p'-DDE and ∑DDTs was 10, 30 and 42μgkg -1 body weight, respectively, in 3months old infants. The p,p'-DDE/p,p'-DDT ratio ranged from 1 to 23, where 58% of the mothers had a ratio below 5 indicating recent or ongoing DDT exposure.This study reports infant exposure and maternal body burden of organochlorines through breast milk. Although the findings give no reason to limit breast-feeding, it is essential to identify the main exposure sources and find means to decrease the exposure. © 2012 Elsevier Ltd. Source


Rylander C.,University of Tromso | Sandanger T.M.,University of Tromso | Sandanger T.M.,Fram High North Research Center for Climate and the Environment | Engeset D.,University of Tromso | Lund E.,University of Tromso
PLoS ONE | Year: 2014

Background: The effects of fish consumption and n-3 fatty acids on type 2 diabetes mellitus (T2DM) have recently been debated. Objective: We explored the risk of T2DM in relation to consumption of lean fish, fatty fish, fish products and total fish as well as cod liver oil supplements in a representative sample of Norwegian women. Design: This was a prospective population based cohort study in 33740 women free of T2DM, stroke, angina or heart attack and with detailed information on important co-variates and dietary intake at baseline. Risk ratios and corresponding 95% CI were estimated using Poisson regression with log-person time as offset. Results: Lean fish consumption was inversely associated with T2DM compared to zero intake. Risk ratios and 95% CI for intake of 75 and 100 g lean fish per day were 0.71 (0.51, 0.98) and 0.67 (0.46, 0.98), respectively. There was no effect of intake of fatty fish, fish products, total fish or use of cod liver oil supplements on the risk of T2DM. Conclusion: Lean fish consumption of 75-100 g/d had a beneficial effect on T2DM. It remains unclear whether lean fish in itself has a protective effect on T2DM or that lean fish consumers have a protective life-style that we were not able to take into account in this study. Unfavorable effects of fatty fish consumption or use of cod liver oil supplements on T2DM were not observed. © 2014 Rylander et al. Source

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