Jena M.,Siksha ‘O’ Anusandhan University |
Jena J.,Siksha ‘O’ Anusandhan University |
Biswal S.B.,Siksha ‘O’ Anusandhan University |
Mishra S.,Siksha ‘O’ Anusandhan University |
Pal A.,HIG 115
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013
Objective- Hypertension is a common disorder rising in incidence once established treatment is obligatory. The causes, so also the drugs are many & usually the treatment is lifelong. Hence research is going on to find out a suitable & safe drug. Herbal products in this regard are worthy of investigation. Eclipta alba Hassk (Bhringaraja) is recently reported to have diuretic & antihypertensive activity in an ayurvedic study. This creates renewed interest for scientific evaluation of the claimed activity. Methods- Hypertension was induced in male wistar albino rats by providing fructose (66%) in their diet for 15 days. Ethanolic extract of Eclipta alba (EEEA) leaves was administered in 100,200&400 mg/kg doses P.O.to different groups of rats for 7days starting from day 16thof fructose administration. The systolic, diastolic & mean arterial pressure (SBP, DBP, MAP) & heart rate(HR) were measured on day 7th,14th,21st& 28thday of administration standard & test drugs by non invasive BP system for rodents. Results- A rise in blood pressure was found on day 16thof fructose diet. EEEA decreased the rise in B.P significantly in a dose dependent manner comparable to Quinapril. Conclusion- Eclipta alba Hassk was found to posses significant antihypertensive activity in rat model. Further study in this line is necessary to pass its beneficial effects to clinical use.