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Märstetten-Dorf, Switzerland

Tsao A.S.,University of Texas M. D. Anderson Cancer Center | Scagliotti G.V.,University of Turin | Bunn P.A.,Aurora University | Carbone D.P.,Ohio State University | And 34 more authors.
Journal of Thoracic Oncology | Year: 2016

Lung cancer continues to be a major global health problem; the disease is diagnosed in more than 1.6 million new patients each year. However, significant progress is underway in both the prevention and treatment of lung cancer. Lung cancer therapy has now emerged as a "role model" for precision cancer medicine, with several important therapeutic breakthroughs occurring during 2015. These advances have occurred primarily in the immunotherapy field and in treatments directed against tumors harboring specific oncogenic drivers. Our knowledge about molecular mechanisms for oncogene-driven tumors and about resistance to targeted therapies has increased quickly over the past year. As a result, several regulatory approvals of new agents that significantly improve survival and quality of life for patients with lung cancer who have advanced disease have occurred. The International Association for the Study of Lung Cancer has gathered experts in different areas of lung cancer research and management to summarize the most significant scientific advancements related to prevention and therapy of lung cancer during the past year. © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Vo Q.D.,HFR Fribourg
BMJ case reports | Year: 2013

We report the case of a patient with a palpable mass and abdominal pain in the left upper quadrant. A physical examination revealed tenderness in this region. An ultrasound performed initially showed a large cystic structure. A CT examination revealed a large cyst originating in the spleen with loculations in its upper part and focal calcification in the wall. On MRI, the cystic mass showed high signal on T1-weighted and T2-weighted images. The carbohydrate antigen 19-9 (CA 19-9) was measured at 88 U/ml (standard <37.1 mUI/l). According to the imaging examinations and laboratory tests performed, it was impossible to determine if the splenic cyst was parasitic or non-parasitic. Given the most important risks of complications encountered in parasitic cysts, it was decided to treat this splenic cyst as a parasitic cyst. For this reason, an elective laparoscopic splenectomy with preoperative embolisation of the splenic artery was performed. The histological diagnosis was a primary epidermoid splenic cyst with inner lining epithelial cells.

Chronic blood malignancies in the elderly remain incurable diseases. However, recent advances in therapies allow not only to extend treatment at advanced ages and in presence of significant comorbidities, but also to induce prolonged remissions. However, this is achieved at the cost of increased risk of infectious diseases, due to disease - and treatment - related immunosuppression. This article will review the infectious diseases associated with chronic lymphatic leukemia, myelodysplastic syndrome and multiple myeloma. Furthermore we will discuss the recommendation of antiinfectious prophylaxis and vaccination for each of the conditions listed above.

Demierre N.,HFR Fribourg | Zoete V.,University of Lausanne | Michielin O.,University of Lausanne | Stauffer E.,Institute of Pathology | And 3 more authors.
Lung Cancer | Year: 2013

We report on the medical history of a Caucasian smoker woman diagnosed with a stage IV NSCLC adenocarcinoma, characterized by a rare epidermal growth factor receptor (EGFR) point mutation in exon 21 codon 843 (p.V843I/c.2527G. >A/COSMIC ID 85894). This genetic alteration revealed to be germline, after its presence was demonstrated in chondroblasts from the bone biopsy. While it is the first description of germline V843I mutation without concomitant additional known EGFR activating mutation, we modeled the EGFR ATP catalytic domain in complex with ATP, gefitinib and erlotinib using computer-aided approaches to estimate possible changes in affinity upon the V843I mutation. © 2012 Elsevier Ireland Ltd.

Boehncke W.-H.,University of Geneva | Anliker M.D.,Cantonal Hospital | Conrad C.,University of Lausanne | Dudler J.,HFR Fribourg | And 11 more authors.
Dermatology | Year: 2015

Background: Psoriatic arthritis (PsA) substantially impacts the management of psoriatic disease. Objective: This study aimed to generate an interdisciplinary national consensus on recommendations of how PsA should be managed. Methods: Based on a systematic literature search, an interdisciplinary expert group identified important domains and went through 3 rounds of a Delphi exercise, followed by a nominal group discussion to generate specific recommendations. Results: A strong consensus was reached on numerous central messages regarding the impact of PsA, screening procedures, organization of the interaction between dermatologists and rheumatologists, and treatment goals. Conclusion: These recommendations can serve as a template for similar initiatives in other countries. At the same time, they highlight the need to take into account the impact of the respective national health care system. © 2015 S. Karger AG, Basel.

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