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Wang H.,Jiangsu University | Hou Y.,Traditional Chinese Medicine Hospital of Heze | Meng X.,Tianjin Medical University | Tian X.,Shandong University of Traditional Chinese Medicine | And 4 more authors.
International Journal of Clinical and Experimental Pathology | Year: 2017

Colorectal carcinoma (CRC) represents the most common malignancy of the intestine with a worldwide increasing incidence. Although the risk factors for CRC are well identified, the molecular mechanism for CRC was still to be revealed. Evidence demonstrated that genetic factors were involved in colorectal carcinogenesis. Recently, the functional polymorphism CD3G rs150376137 was reported to correlate with hepatocellular carcinoma risk. However, its role in CRC risk was not clear. In the current study, a hospital-based case-control study including 523 CRC cases and 617 healthy controls was implemented to evaluate the association between rs150376137 and CRC risk. As genotyping data showed, when compared with the reference (del/del), the heterozygote and homozygote ins/ins of rs150376137 were associated with a significantly increased risk of CRC after controlling for other confounders such as age, sex, drinking status, smoking status and BMI (adjusted OR=1.33, 95% C.I. 1.01-1.72, P=0.049; OR=1.69, 95% C.I.1.18-2.67, P=0.017, respectively). It had similar trends in other three genetic models. Moreover, further stratification analysis showed that the differences between cases and controls were more salient in smokers (P < 0.05). Further luciferase-based transient transfection assays revealed that rs150376137 can affect promoter activity of CD3G (P < 0.01). Our data suggested that common genetic polymorphisms in CD3G may influence HCC risk in Chinese population. The replication of our studies in other ethnicities and further functional studies are required for fully understanding the roles of CD3Gpolymorphisms in predisposition for CRC.

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