Hetero Drugs Ltd. Balanagar

Hyderabad, India

Hetero Drugs Ltd. Balanagar

Hyderabad, India
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Tulja Rani R.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Sankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd. Balanagar | Suthakaran R.,P.A. College | Satyanarayana B.,Neosun Biotech India Pvt
International Journal of PharmTech Research | Year: 2010

Three simple, sensitive and accurate visible spectrophotometric methods (A, B and C) have been developed for the estimation of drotoverine hydrochloride in bulk and in pharmaceutical formulations. Method A, B are based on the Ion pair complex of the drug with two dyes namely erichrome black T and orange G in acidic buffer solution followed by their extraction into organic solvent, chloroform. The absorbance of chloroform layer was measured at the respective wavelength of maximum absorbance against the reagent blank. Method C is based on the oxidation /reduction reaction between drotaverine hydrochloride and folin-ciocalteu phenol's reagent to form a blue colored chromogen. All the variables have been optimized. The concentrations of measurements are reproducible within a relative standard deviation of less than 1%. The linearity was found to be 5 to 40, 5 to 30, and 10 to 70 μg/mL for method A, B and C respectively. The proposed methods were validated statistically. Recovery studies were carried out by standard addition method.

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