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Patent
Hess and Betzig | Date: 2017-08-09

A method for providing an image of a sample, the method comprising:(a) providing activation radiation to a sample that includes phototransformable optical labels (PTOLs), the PTOLs being distributed in at least a portion of the sample with a density greater than an inverse of the diffraction-limited resolution volume of imaging optics, and the PTOLs being transformable from an inactivated state wherein the labels radiate little, if any, radiation at a wavelength characteristic of an activated and excited PTOL when exposed to excitation radiation, to an activated state wherein illumination by excitation radiation results in detectable fluorescence emission of radiation, to activate a first subset of the PTOLs in the sample;(b) providing deactivation radiation to the sample to transform activated PTOLs to an unactivated state, wherein the deactivation radiation has a spatially-structured radiation field including intensity minima, such that a second subset of PTOLs located substantially at the minima of the deactivating radiation remain activated, while activated PTOLs exposed to the deactivating radiation outside the minima are substantially transformed into an unactivated form;(c) providing excitation radiation to the sample to excite at least a portion of the activated PTOLs in the sample;(d) controlling the intensity of the first activation radiation and controlling at least one of the intensity and the spatial structure of the deactivation radiation such that radiation emitted from activated and excited PTOLs located at the minima of the deactivation radiation in the sample is emitted substantially from at least one volume that is comparable to or less than a diffraction-limited resolution volume (DLRV) of the imaging optics;(e) detecting fluorescence radiation emitted from the activated and excited PTOLs with the imaging optics and determining the locations of the activated and excited PTOLs with superresolution accuracy;(f) repeating (a) - (e), wherein the minima of the of the deactivating radiation are at different locations in the sample during different repetitions of (b); and(g) combining the determined locations of the PTOLs from the different images to build up a superresoluiton image of the sample.


News Article | June 23, 2017
Site: www.businesswire.com

NEW YORK--(BUSINESS WIRE)--Hess Corporation (NYSE:HES) announced today that John Hess, Chief Executive Officer, will present at the J.P. Morgan 2017 Energy Equity Conference in New York on Tuesday, June 27 at 3:20 p.m. Eastern Time. A live audio webcast and a replay of the presentation will be available. Hess Corporation is a leading global independent energy company engaged in the exploration and production of crude oil and natural gas. More information on Hess Corporation is available at http://www.hess.com. This news release contains projections and other forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These projections and statements reflect the company’s current views with respect to future events and financial performance. No assurances can be given, however, that these events will occur or that these projections will be achieved, and actual results could differ materially from those projected as a result of certain risk factors. A discussion of these risk factors is included in the company’s periodic reports filed with the Securities and Exchange Commission.


An oil forming composition and a method of producing a synthetic crude oil are provided. The oil forming composition includes a mixture of an organic material selected from the group consisting of a member of the lactuca genus, nuts, nut derivatives, vegetable oils, pine tree derivatives, animal protoplasm, and combinations thereof; and a mineral aggregate selected from the group consisting of a silica containing mineral aggregate and a quartz containing mineral aggregate. The method of producing synthetic crude oil includes positioning a first heating enclosure adjacent to a heating surface, providing an oil forming composition within the first heating enclosure, positioning a lid over the oil forming composition, simultaneously applying pressure to the lid and heating the oil forming composition, cooling the oil forming composition to form a pre-volatile oil product, and heating the pre-volatile oil product while exposed to air to form the synthetic volatile fuel.


Strutt J.,Astrimar | Wells D.,Hess
Proceedings of the Annual Offshore Technology Conference | Year: 2014

API PvP 17N provides a structured approach which organizations can adopt to manage risk and uncertainties related to reliability and integrity performance throughout the life of a project. This may range from the management of general project risk through to the identification and removal of potential failure modes in particular equipment. The basic approach is simple and consistent, and when applied correctly has the potential to greatly reduce the financial risk of designing, manufacturing, installing and operating subsea equipment and/or systems. This paper presents the principals and approaches used in API 17N, what it is in general, and why it was written. It will describe the status of its update, including the reasons for the revision and the addition of Integrity Management. It will not cover the detail of the RP, but instead it will describe the underlying paradigm and key processes and how it is being written to facilitate and enable wider application to other technical disciplines. Finally the paper will outline its relationship to other API documents, standards and industry initiatives and what we have learnt from the recent events. Copyright © 2014, Offshore Technology Conference.


Duhon H.,GATE | Cronin J.,Hess
Society of Petroleum Engineers - SPE E and P Health, Safety, Security and Environmental Conference - Americas 2015 | Year: 2015

A HAZOP is a team-based process hazard analysis (PHA) method. Its purpose is to identify hazards and operability issues in a process design. In some HAZOPs, identified issues are evaluated for risk. An effective risk assessment method allows the HAZOP participants and the project team to focus their time and energy on the more significant hazards. Risk assessments in HAZOPs are typically performed using a simple risk matrix (Figure 2). In the risk matrix approach, participants make judgments as to the potential severity and the likelihood of an event. The combination of severity and likelihood indicates the risk. The risk matrix will often be color coded with green areas (OK), red areas (Unacceptable) and yellow areas (improvement suggested, subject to ALARP). This approach is problematic for a number of reasons: 1. The judgment of consequence severity is difficult and is often ambiguous. Any identified scenario could play out in multiple ways often with dramatically different severities. 2. Estimation of the frequency or likelihood of the event is also difficult; especially so if the frequency of the mitigated event is to be estimated. 3. The simple green, yellow, red bands do not provide sufficient resolution for ranking scenarios (the yellow band may span two or three orders of magnitude, for instance). This paper presents a more rigorous and repeatable approach to making the severity and frequency judgments that is also simpler and quicker. The method is, in effect, a simplified layer of protection analysis (LOPA). The authors show how LOPA techniques can be simplified and applied in a HAZOP setting for both frequency and consequence severity judgments. These simplified techniques make such judgments more rigorous and repeatable. Also, because the guesswork is removed, this saves time in the HAZOP. The proposed approach also yields a HAZOP record that is more easily used for a future LOPA study. Copyright 2015, Society of Petroleum Engineers.


Patent
Hess and Betzig | Date: 2012-05-16

First activation radiation is provided to a sample (601) that includes phototransformable optical labels (PTOLs) to activate a first subset of the PTOLs in the sample (601). First excitation radiation is provided to the first subset of PTOLs in the sample (601) to excite at least some of the activated PTOLs, and radiation emitted from activated and excited PTOLs within the first subset of PTOLs is detecting with imaging optics (602). The first activation radiation is controlled such that the mean volume per activated PTOLs in the first subset is greater than or approximately equal to a diffraction-limited resolution volume (DLRV) of the imaging optics (602).The first activation radiation and/or the first excitation radiation is provided to the sample (601) through a multi-photon absorption process. The PTOLs may be formed by photoactivated or photoswitched fluorescent proteins. The method and the apparatus allow to obtain superresolution images.


Patent
Hess and Betzig | Date: 2012-05-16

The invention relates to a method of imaging and a corresponding optical system characterized by a diffraction-limited resolution volume. Within the method, a sample is imaged comprising a plurality of transformable optical labels distributed in at least a portion of the sample with a density greater than an inverse of the diffraction-limited resolution volume of the optical system. The method includes the steps of activating a first subset of the labels in the portion of the sample, wherein the density of the labels in the first subset is less than the inverse of the diffraction-limited resolution volume; exciting a portion of the labels in the first subset of labels, in particular by using excitation radiation; detecting radiation emitted from the activated and excited labels in the first subset of labels with the imaging optics; and determining locations of activated and excited labels in the first subset of labels with a sub-diffraction-limited accuracy based on the detected radiation emitted from the activated and excited labels. The transformable optical labels may be formed by photoactivated or photoswitched fluorescent proteins. The method and the optical system allow to obtain superresolution images.


Patent
Hess and Betzig | Date: 2012-05-16

First activation radiation is provided to a sample that includes phototransformable optical labels (PTOLs) to activate a first subset of the PTOLs in the sample. First excitation radiation is provided to the first subset of PTOLs in the sample to excite at least some of the activated PTOLs, and radiation emitted from activated and excited PTOLs within the first subset of PTOLs is detecting with imaging optics. The first activation radiation is controlled such that the mean volume per activated PTOLs in the first subset is greater than or approximately equal to a diffraction-limited resolution volume (DLRV) of the imaging optics.The polarization of at least one of the activation radiation and the excitation radiation provided to the sample is controlled. The PTOLs may be formed by photoactivated or photoswitched fluorescent proteins. The method and the apparatus allow to obtain superresolution images.


Patent
Hess and Betzig | Date: 2012-05-16

The invention relates to a method comprising steps of: providing spatially-structured activation radiation having relatively high- and relatively low-intensity regions to a sample that includes phototransformable optical labels (PTOLs) to activate a subset of the PTOLs in the sample located predominately at relatively high intensity regions of the spatially-structured activation radiation; providing spatially-structured excitation radiation to the subset of activated PTOLs in the sample, wherein the exciting radiation is structured so that one or more relatively high intensity regions of the excitation radiation at least partially overlap one or more relatively high intensity regions of the activating radiation; detecting radiation emitted from the activated and excited PTOLs with imaging optics; and controlling the intensities and spatial structures of the activating radiation and the exciting radiation so that radiation emitted from PTOLs in the sample is emitted substantially from at least one volume that is comparable to or less than a diffraction-limited resolution volume (DLRV) of the imaging optics. The PTOLs may be formed by photoactivated or photoswitched fluorescent proteins. The invention also relates to a corresponding system.


Patent
Hess and Betzig | Date: 2012-05-16

First activation radiation is provided to a sample (601) that includes phototransformable optical labels (PTOLs) to activate a first subset of the PTOLs in the sample (601). First excitation radiation is provided to the first subset of PTOLs in the sample (601) to excite at least some of the activated PTOLs, and radiation emitted from activated and excited PTOLs within the first subset of PTOLs is detecting with imaging optics (602). The first activation radiation is controlled such that the mean volume per activated PTOLs in the first subset is greater than or approximately equal to a diffraction-limited resolution volume (DLRV) of the imaging optics (602).The sample (601) comprises at least a first species and a second species of PTOL, which are distinguished from each other based on at least one of emission characteristics of the first and second species and excitation characteristics of the first and second species. A density of each species of PTOL in the sample is greater than the inverse of DLRV of the imaging optics, and a density of species of PTOL in the first subset of activated PTOLs of that species is less than the inverse of the diffraction-limited resolution volume. The PTOLs may be formed by photoactivated or photoswitched fluorescent proteins. The method and the apparatus allow to obtain superresolution images.

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