Yakubovskaya R.I.,Herzen Moscow Research Oncological Institutes |
Morozova N.B.,Herzen Moscow Research Oncological Institutes |
Pankratov A.A.,Herzen Moscow Research Oncological Institutes |
Kazachkina N.I.,Herzen Moscow Research Oncological Institutes |
And 13 more authors.
Russian Journal of General Chemistry
Photodynamic therapy and fluorescence diagnosis of malignant tumors have been actively developed over the last 15 years by the scientists participating in the Moscow Government-funded "Fight against Cancer" program. New effective photosensitizers absorbing in the long-wave spectral region were revealed. Unique agents Alasens-lio, Alasens-gel, Hexasens-lio, Phthalosens-lio, Holosens-lio, and Holosensgel were produced and preclinically studied both in vitro and in vivo. New methods using low-intensity and pulse modes of irradiation and also combined methods of treatment by photodynamic therapy and well-known chemotherapy or laser hyperthermia were developed. Methodological recommendations for experimental studies of agents with photoinduced antitumor properties were published. © 2015 Pleiades Publishing, Ltd. Source