Clinical features and therapeutic results of primary mediastinal large B- cells non-Hodgkins lymphomas [Características clínicas y resultados terapéuticos de linfomas no hodgkin de células grandes B mediastinal primarios]
Medina R.C.,Hospital Clinicoquirurguco Hermanos Ameijeiras |
Uria J.C.,Hospital Clinicoquirurguco Hermanos Ameijeiras |
Arenas R.C.,Hospital Clinicoquirurguco Hermanos Ameijeiras |
Perurena J.M.,Hospital Clinicoquirurguco Hermanos Ameijeiras |
And 2 more authors.
Revista Cubana de Medicina | Year: 2011
A retrospective, descriptive and observational study was conducted to assess the clinical-biological features and the therapeutic results of the primary mediastinal of large B cells lymphoma in 34 patients seen in the Hermanos Ameijeiras Clinical Surgical Hospital from June, 1989 to February, 2009. There was predominance of female sex (61.8 %), mean age of 31.5 years (19 to 61 years) and of white race (70.6 %). The localized stages were more frequent (67.7 %), without B symptoms (64.7 %) and with a large tumor mass (70.6 %). Global survival and the free of progression survival at five years were of 53.4 and 43.4 %, respectively. The global survival at three years of the patients treated with MACOPB/VACOPB, CHOP and RCHOP was of 77.7; 30.4 and 100 %, respectively. It was proved that patientstreated with MACOPB/VACOPB had better results than those treated with CHOP. Age-adjusted international prognostic rate was not a survival predictor. In multivariable analysis, the only survival predictor was the applied (CHOP versus MACOPB). The routine use of radiotherapy has neither a significant impact on the global survival nor on the free of progression survival at five years.