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Toppenish, WA, United States

Heritage University is a higher education institution located in Toppenish, Washington, on the Yakama Indian Reservation. It offers associate's, bachelor's, and master's degrees in a number of academic disciplines, including: English business administration mathematics computer science chemistry biology social workeducation↑ 1.0 1.1 Wikipedia.

Lee A.H.,Midwestern University | Oconnor P.M.,Heritage University
Journal of Vertebrate Paleontology | Year: 2013

Noasauridae is a clade of ceratosaurian theropods that evolved small body size independently of other non-avian theropods. The best-preserved and most complete noasaurid is Masiakasaurus knopfleri from the Maastrichtian-aged Maevarano Formation in Madagascar. An abundance of skeletal material from several individuals spanning a wide range of ontogeny makes Masiakasaurus an ideal candidate for the analysis of growth. We histologically sampled a growth series of elements consisting of four femora and three tibiae. Bright-field and circularly polarized light microscopy were used to distinguish between slowly and rapidly growing forms of bone. To simultaneously estimate age at death and reconstruct growth trajectories, we measured the perimeters of growth lines in each specimen and fitted models to these data using a novel application of mixed-effects regression. Our histological results show an external fundamental system in the largest tibial specimen and confirm that Masiakasaurus grew determinately, matured at small body size, and is not the juvenile form of a larger-bodied theropod. Parallel-fibered bone is unusually prominent and suggests relatively slow growth. Moreover, our quantitative analysis shows that the average individual took about 8-10 years to get to the size of a large dog. Although Masiakasaurus grew 40% faster than crocodylians, it grew about 40% slower than comparably sized non-avian theropods. Slowed growth may have evolved as a means to minimize structural and maintenance costs while living in a semiarid and seasonally stressful environment. Dimorphism does not appear related to asymptotic size or growth rate but seems to reflect the degree of skeletal maturity. © 2013 Taylor and Francis Group, LLC. Source

Wurm-Schaar M.,Heritage University
Biochemical Pharmacology | Year: 2015

The construct of a profession encompasses several core elements that guide the behavior of its members and the quality standards for the services they provide and products they produce: primarily, competency specifications for members of the profession, a code of professional and ethical behavior, and a commitment to serve the public good. Professionalism is the embodiment of a profession's expertise, ethos, and service to the public good. As an academic scientist, David Triggle exhibited an extraordinary mastery of professionalism in two domains: science and academic leadership in higher education. Sociocultural changes, including the commodification of knowledge, science, and higher education, are posing challenges to the professions and their traditional values. Whereas the effectiveness of ethics instruction is questionable, positive mentoring has shown promise as a means to help professionals maintain the ideals and the values of their chosen occupations. David Triggle was an extremely effective and revered mentor to numerous individuals in the sciences as well as in higher education, enhancing their professional enculturation and development. He fostered integrity of purpose in our respective professional lives and work, and was and remains an exemplar of professionalism. © 2015 Elsevier Inc. Source

Stuss D.T.,Rotman Research Institute | Stuss D.T.,Heritage University
Neuropsychological Rehabilitation | Year: 2011

Cognitive neurorehabilitation is rooted both in the cognitive function being treated and the neural substrates underlying that ability. Recent progress in understanding both brain (in particular brain plasticity) and the complexities of behaviour imply a promising future for cognitive neurorehabilitation. The manuscripts in this issue focuse on advances in the use of non-invasive brain stimulation (NIBS) as a tool for cognitive neurorehabilitation. This paper presents a broader context in which to understand the importance and potential of this specific approach. Achieving the promise requires theoretical and experimental rigour including selection of relevant outcome measures, and understanding of the complexities of individual patients. Success will depend on our ability to integrate knowledge and approaches. © 2011 Psychology Press. Source

Oglesby-Sherrouse A.G.,University of Maryland, Baltimore | Murphy E.R.,Heritage University
Metallomics | Year: 2013

For most living organisms, iron is both essential and potentially toxic, making the precise maintenance of iron homeostasis necessary for survival. To manage this paradox, bacteria regulate the acquisition, utilization, and storage of iron in response to its availability. The iron-dependent ferric uptake repressor (Fur) often mediates this iron-responsive regulation by both direct and indirect mechanisms. In 2002, Masse and Gottesman identified a novel target of Fur-mediated regulation in Escherichia coli: a gene encoding a small regulatory RNA (sRNA) termed RyhB. Under conditions of iron-limitation, RyhB is produced and functions to regulate the expression of several target genes encoding iron-utilizing enzymes, iron acquisition systems, and iron storage factors. This pivotal finding provided the missing link between environmental iron-limitation and previously observed decreases in certain iron-dependent metabolic pathways, a phenomenon now referred to as an "iron-sparing" response. The discovery of RyhB opened the door to the rapidly expanding field of bacterial iron-regulated sRNAs, which continue to be identified and described in numerous bacterial species. Most striking are findings that the impact of iron-responsive sRNA regulation often extends beyond iron homeostasis, particularly with regard to production of virulence-associated factors by pathogenic bacteria. This review discusses trends in the collective body of work on iron-regulated sRNAs, highlighting both the regulatory mechanisms they utilize to control target gene expression and the impact of this regulation on basic processes controlling bacterial physiology and virulence. © 2013 The Royal Society of Chemistry. Source

Li Y.V.,Heritage University
Endocrine | Year: 2014

Zinc (Zn2+) is an essential element crucial for growth and development, and also plays a role in cell signaling for cellular processes like cell division and apoptosis. In the mammalian pancreas, Zn2+ is essential for the correct processing, storage, secretion, and action of insulin in beta (β)-cells. Insulin is stored inside secretory vesicles or granules, where two Zn2+ ions coordinate six insulin monomers to form the hexameric-structure on which maturated insulin crystals are based. The total Zn2+ content of the mammalian pancreas is among the highest in the body, and Zn2+ concentration reach millimolar levels in the interior of the dense-core granule. Changes in Zn2+ levels in the pancreas have been found to be associated with diabetes. Hence, the relationship between co-stored Zn2+ and insulin undoubtedly is critical to normal β-cell function. The advances in the field of Zn2+ biology over the last decade have facilitated our understanding of Zn2+ trafficking, its intracellular distribution and its storage. When exocytosis of insulin occurs, insulin granules fuse with the β-cell plasma membrane and release their contents, i.e., insulin as well as substantial amount of free Zn2+, into the extracellular space and the local circulation. Studies increasingly indicate that secreted Zn2+ has autocrine or paracrine signaling in β-cells or the neighboring cells. This review discusses the Zn2+ homeostasis in β-cells with emphasis on the potential signaling role of Zn2+ to islet biology. © 2013 Springer Science+Business Media New York. Source

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