Herbert Irving Comprehensive Cancer Center

New York City, NY, United States

Herbert Irving Comprehensive Cancer Center

New York City, NY, United States

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News Article | February 27, 2017
Site: www.eurekalert.org

(PRINCETON, N.J., Feb. 27, 2017) - Bristol-Myers Squibb Company (NYSE:BMY) today announced that Columbia University Medical Center and Peter MacCallum Cancer Centre (Peter Mac) have joined the International Immuno-Oncology Network (II-ON), a global peer-to-peer collaboration between Bristol-Myers Squibb and academia that aims to advance Immuno-Oncology (I-O) science and translational medicine to improve patient outcomes. Launched in 2012 by Bristol-Myers Squibb, the II-ON was one of the first networks to bring academia and industry together to further the scientific understanding of I-O, and has expanded from 10 to 15 sites including more than 250 investigators working on over 150 projects across 20 tumor types. The II-ON has generated cutting-edge I-O data that have informed the development of new I-O agents, yielded publications and produced some of the earliest findings on a variety of biomarkers and target identification and validation. "Bristol-Myers Squibb has long believed the future of cancer research is dependent on investments in science and partnerships. We formed the II-ON to facilitate innovation in I-O science and drug discovery by providing a streamlined framework for peer-to-peer collaboration among global cancer research leaders," said Nils Lonberg, Head of Oncology Biology Discovery at Bristol-Myers Squibb. "The significant discoveries generated by the II-ON over the past five years have not only informed our robust early I-O pipeline, but also serve to advance the entire field. We are proud to collaborate with Columbia University Medical Center and Peter Mac, and together with the entire II-ON will continue to lead pioneering research and heighten our collective understanding of the science behind I-O." Through the II-ON, Bristol-Myers Squibb is collaborating with leading cancer research institutions around the world to generate innovative I-O science, launch biology-driven trials and seek out cutting-edge technologies with the goal of translating research findings into clinical trials and, ultimately, clinical practice. "I-O research may be transforming the way we treat cancer," said Charles G. Drake, MD, PhD, Professor of Medicine at Columbia University Medical Center and Director of Genitourinary Oncology and Associate Director for Clinical Research at the Herbert Irving Comprehensive Cancer Center at New York-Presbyterian/Columbia. "The II-ON offers a tremendous opportunity to work smarter and faster along with our colleagues to address fundamental scientific questions in I-O." "We believe the collective knowledge and research power of the II-ON will generate groundbreaking findings in I-O with the potential to improve outcomes for people affected by cancer," said Professor Joe Trapani, Executive Director Cancer Research and Head of the Cancer Immunology Program at Peter MacCallum Cancer Centre, Melbourne, Australia. Building on the success of the II-ON, Bristol-Myers Squibb has invested in several other models of scientific collaboration with academic partners across the globe, including the Global Expert Centers Initiative (GECI) and the Immuno-Oncology Integrated Community Oncology Network (IO-ICON). "We believe a one-size-fits-all research approach does not facilitate innovation," said Lonberg. "Our tailored collaborations with academic centers expand our research capabilities and accelerate our collective ability to deliver potentially life-changing results for patients." The II-ON, formed in 2012, is a global peer-to-peer collaboration between Bristol-Myers Squibb and academia advancing the science of Immuno-Oncology (I-O) through a series of preclinical, translational and biology-focused research objectives. The research in the collaboration is focused on three fundamental scientific pillars: understanding the mechanisms of resistance to immunotherapy; identifying patient populations likely to benefit from immunotherapy; and exploring novel combination therapies that may enhance anti-tumor response through complementary mechanisms of action. The II-ON facilitates the translation of scientific research findings into drug discovery and development, with the goal of introducing new treatment options into clinical practice. In addition to Bristol-Myers Squibb, the II-ON currently comprises 15 leading cancer research institutions, including: Clinica Universidad Navarra, Dana-Farber Cancer Institute, The Earle A. Chiles Research Institute (Providence Health & Services), Institut Gustave Roussy, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione G. Pascale", Bloomberg-Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center, Memorial Sloan Kettering Cancer Center, National Cancer Center Japan, The Netherlands Cancer Institute, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, University College London, The University of Chicago, West German Cancer Center/University Hospital Essen, and now Columbia University Medical Center and Peter MacCallum Cancer Centre. Bristol-Myers Squibb: At the Forefront of Immuno-Oncology Science & Innovation At Bristol-Myers Squibb, patients are at the center of everything we do. Our vision for the future of cancer care is focused on researching and developing transformational Immuno-Oncology (I-O) medicines that will raise survival expectations in hard-to-treat cancers and will change the way patients live with cancer. We are leading the scientific understanding of I-O through our extensive portfolio of investigational and approved agents - including the first combination of two I-O agents in metastatic melanoma - and our differentiated clinical development program, which is studying broad patient populations across more than 20 types of cancers with 12 clinical-stage molecules designed to target different immune system pathways. Our deep expertise and innovative clinical trial designs uniquely position us to advance the science of combinations across multiple tumors and potentially deliver the next wave of I-O combination regimens with a sense of urgency. We also continue to pioneer research that will help facilitate a deeper understanding of the role of immune biomarkers and inform which patients will benefit most from I-O therapies. We understand making the promise of I-O a reality for the many patients who may benefit from these therapies requires not only innovation on our part, but also close collaboration with leading experts in the field. Our partnerships with academia, government, advocacy and biotech companies support our collective goal of providing new treatment options to advance the standards of clinical practice. Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol-Myers Squibb, visit us at BMS.com or follow us on LinkedIn, Twitter, YouTube and Facebook. This press release contains "forward-looking statements" as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding the research, development and commercialization of pharmaceutical products. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes and results to differ materially from current expectations. No forward-looking statement can be guaranteed. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect Bristol-Myers Squibb's business, particularly those identified in the cautionary factors discussion in Bristol-Myers Squibb's Annual Report on Form 10-K for the year ended December 31, 2016 in our Quarterly Reports on Form 10-Q and our Current Reports on Form 8-K. Bristol-Myers Squibb undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.


PRINCETON, N.J.--(BUSINESS WIRE)--Bristol-Myers Squibb Company (NYSE:BMY) today announced that Columbia University Medical Center and Peter MacCallum Cancer Centre (Peter Mac) have joined the International Immuno-Oncology Network (II-ON), a global peer-to-peer collaboration between Bristol-Myers Squibb and academia that aims to advance Immuno-Oncology (I-O) science and translational medicine to improve patient outcomes. Launched in 2012 by Bristol-Myers Squibb, the II-ON was one of the first networks to bring academia and industry together to further the scientific understanding of I-O, and has expanded from 10 to 15 sites including more than 250 investigators working on over 150 projects across 20 tumor types. The II-ON has generated cutting-edge I-O data that have informed the development of new I-O agents, yielded publications and produced some of the earliest findings on a variety of biomarkers and target identification and validation. “Bristol-Myers Squibb has long believed the future of cancer research is dependent on investments in science and partnerships. We formed the II-ON to facilitate innovation in I-O science and drug discovery by providing a streamlined framework for peer-to-peer collaboration among global cancer research leaders,” said Nils Lonberg, Head of Oncology Biology Discovery at Bristol-Myers Squibb. “The significant discoveries generated by the II-ON over the past five years have not only informed our robust early I-O pipeline, but also serve to advance the entire field. We are proud to collaborate with Columbia University Medical Center and Peter Mac, and together with the entire II-ON will continue to lead pioneering research and heighten our collective understanding of the science behind I-O.” Through the II-ON, Bristol-Myers Squibb is collaborating with leading cancer research institutions around the world to generate innovative I-O science, launch biology-driven trials and seek out cutting-edge technologies with the goal of translating research findings into clinical trials and, ultimately, clinical practice. “I-O research may be transforming the way we treat cancer,” said Charles G. Drake, MD, PhD, Professor of Medicine at Columbia University Medical Center and Director of Genitourinary Oncology and Associate Director for Clinical Research at the Herbert Irving Comprehensive Cancer Center at New York-Presbyterian/Columbia. “The II-ON offers a tremendous opportunity to work smarter and faster along with our colleagues to address fundamental scientific questions in I-O.” “We believe the collective knowledge and research power of the II-ON will generate groundbreaking findings in I-O with the potential to improve outcomes for people affected by cancer,” said Professor Joe Trapani, Executive Director Cancer Research and Head of the Cancer Immunology Program at Peter MacCallum Cancer Centre, Melbourne, Australia. Building on the success of the II-ON, Bristol-Myers Squibb has invested in several other models of scientific collaboration with academic partners across the globe, including the Global Expert Centers Initiative (GECI) and the Immuno-Oncology Integrated Community Oncology Network (IO-ICON). "We believe a one-size-fits-all research approach does not facilitate innovation,” said Lonberg. “Our tailored collaborations with academic centers expand our research capabilities and accelerate our collective ability to deliver potentially life-changing results for patients." The II-ON, formed in 2012, is a global peer-to-peer collaboration between Bristol-Myers Squibb and academia advancing the science of Immuno-Oncology (I-O) through a series of preclinical, translational and biology-focused research objectives. The research in the collaboration is focused on three fundamental scientific pillars: understanding the mechanisms of resistance to immunotherapy; identifying patient populations likely to benefit from immunotherapy; and exploring novel combination therapies that may enhance anti-tumor response through complementary mechanisms of action. The II-ON facilitates the translation of scientific research findings into drug discovery and development, with the goal of introducing new treatment options into clinical practice. In addition to Bristol-Myers Squibb, the II-ON currently comprises 15 leading cancer research institutions, including: Clinica Universidad Navarra, Dana-Farber Cancer Institute, The Earle A. Chiles Research Institute (Providence Health & Services), Institut Gustave Roussy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, Bloomberg-Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center, Memorial Sloan Kettering Cancer Center, National Cancer Center Japan, The Netherlands Cancer Institute, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, University College London, The University of Chicago, West German Cancer Center/University Hospital Essen, and now Columbia University Medical Center and Peter MacCallum Cancer Centre. Bristol-Myers Squibb: At the Forefront of Immuno-Oncology Science & Innovation At Bristol-Myers Squibb, patients are at the center of everything we do. Our vision for the future of cancer care is focused on researching and developing transformational Immuno-Oncology (I-O) medicines that will raise survival expectations in hard-to-treat cancers and will change the way patients live with cancer. We are leading the scientific understanding of I-O through our extensive portfolio of investigational and approved agents – including the first combination of two I-O agents in metastatic melanoma – and our differentiated clinical development program, which is studying broad patient populations across more than 20 types of cancers with 12 clinical-stage molecules designed to target different immune system pathways. Our deep expertise and innovative clinical trial designs uniquely position us to advance the science of combinations across multiple tumors and potentially deliver the next wave of I-O combination regimens with a sense of urgency. We also continue to pioneer research that will help facilitate a deeper understanding of the role of immune biomarkers and inform which patients will benefit most from I-O therapies. We understand making the promise of I-O a reality for the many patients who may benefit from these therapies requires not only innovation on our part, but also close collaboration with leading experts in the field. Our partnerships with academia, government, advocacy and biotech companies support our collective goal of providing new treatment options to advance the standards of clinical practice. Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol-Myers Squibb, visit us at BMS.com or follow us on LinkedIn, Twitter, YouTube and Facebook. This press release contains “forward-looking statements” as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding the research, development and commercialization of pharmaceutical products. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes and results to differ materially from current expectations. No forward-looking statement can be guaranteed. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect Bristol-Myers Squibb’s business, particularly those identified in the cautionary factors discussion in Bristol-Myers Squibb’s Annual Report on Form 10-K for the year ended December 31, 2016 in our Quarterly Reports on Form 10-Q and our Current Reports on Form 8-K. Bristol-Myers Squibb undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.


CHICAGO, May 24, 2017 (GLOBE NEWSWIRE) -- Dr. Andrea Califano, a pioneer in cancer systems biology and a renowned researcher at Columbia University, has joined the Tempus Scientific Advisory Board. In this role, he will serve as an advisor to the company and will bring his decades of experience researching the clinical implications of how DNA mutations and RNA expression levels interact at the proteomic level. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/41e3b884-5da3-4ca3-be81-004d958c132b “I have spent my career working to determine the genetic drivers of cancer and believe that with the intersection of science and technology, we are on the verge of transforming the way cancer care is delivered,” said Dr. Andrea Califano. “I am excited to join the Scientific Board at Tempus and to help them accelerate the broad application of data in both the research and clinical environment.” Dr. Califano is the Clyde and Helen Wu Professor of Chemical Systems Biology at Columbia University Medical Center. He is the Founding Chair of the Department of Systems Biology, Director of the JP Sulzberger Columbia Genome Center, and Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center, and also holds appointments in the Department of Biochemistry & Molecular Biophysics and Department of Biomedical Informatics. He joins the board along with Dr. Arul M. Chinnaiyan and Dr. David Agus. Meanwhile, DarwinHealth, a precision focused cancer medicine company, co-founded by Dr. Califano, that uses RNA analysis in an effort to match patients with treatments has partnered with Tempus on a personalized medicine research initiative aimed at improving outcomes for patients diagnosed with cancer. As part of the collaboration, Tempus will use information obtained from DarwinHealth reports in conjunction with approximately 2,000 de-identified patients for whom Tempus has done genetic sequencing of normal, tumor DNA and RNA in an effort to further explore protein interactions and tumor growth. The collaboration with DarwinHealth, using a systems biology approach to cancer care, will leverage the deep molecular and clinical data that Tempus collects daily, and the algorithms that Andrea has developed over the last decade, to help determine the driving force behind various cancers. “At Tempus, we are on a mission to recruit the best and brightest minds in cancer to help shape and guide the future of cancer treatment,” said Eric Lefkofsky, Co-founder and CEO at Tempus. “This partnership is consistent with that commitment as both Andrea and DarwinHealth are pioneering new ways to explore protein interactions that might open the door to an entirely new class of therapeutics.” Tempus provides molecular sequencing and clinical analytic solutions to top academic centers, hospital systems, associations, and healthcare providers. About Tempus: Tempus is a technology company that is building the world’s largest library of molecular and clinical data and an operating system to make that data accessible and useful. We enable physicians to deliver personalized cancer care for patients through our interactive analytical and machine learning platform. We provide genomic sequencing services and analyze molecular and therapeutic data to empower physicians to make real-time, data-driven decisions. Our goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as we gather more data. For more information, visit tempus.com.


CHICAGO, May 24, 2017 (GLOBE NEWSWIRE) -- Dr. Andrea Califano, a pioneer in cancer systems biology and a renowned researcher at Columbia University, has joined the Tempus Scientific Advisory Board. In this role, he will serve as an advisor to the company and will bring his decades of experience researching the clinical implications of how DNA mutations and RNA expression levels interact at the proteomic level. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/41e3b884-5da3-4ca3-be81-004d958c132b “I have spent my career working to determine the genetic drivers of cancer and believe that with the intersection of science and technology, we are on the verge of transforming the way cancer care is delivered,” said Dr. Andrea Califano. “I am excited to join the Scientific Board at Tempus and to help them accelerate the broad application of data in both the research and clinical environment.” Dr. Califano is the Clyde and Helen Wu Professor of Chemical Systems Biology at Columbia University Medical Center. He is the Founding Chair of the Department of Systems Biology, Director of the JP Sulzberger Columbia Genome Center, and Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center, and also holds appointments in the Department of Biochemistry & Molecular Biophysics and Department of Biomedical Informatics. He joins the board along with Dr. Arul M. Chinnaiyan and Dr. David Agus. Meanwhile, DarwinHealth, a precision focused cancer medicine company, co-founded by Dr. Califano, that uses RNA analysis in an effort to match patients with treatments has partnered with Tempus on a personalized medicine research initiative aimed at improving outcomes for patients diagnosed with cancer. As part of the collaboration, Tempus will use information obtained from DarwinHealth reports in conjunction with approximately 2,000 de-identified patients for whom Tempus has done genetic sequencing of normal, tumor DNA and RNA in an effort to further explore protein interactions and tumor growth. The collaboration with DarwinHealth, using a systems biology approach to cancer care, will leverage the deep molecular and clinical data that Tempus collects daily, and the algorithms that Andrea has developed over the last decade, to help determine the driving force behind various cancers. “At Tempus, we are on a mission to recruit the best and brightest minds in cancer to help shape and guide the future of cancer treatment,” said Eric Lefkofsky, Co-founder and CEO at Tempus. “This partnership is consistent with that commitment as both Andrea and DarwinHealth are pioneering new ways to explore protein interactions that might open the door to an entirely new class of therapeutics.” Tempus provides molecular sequencing and clinical analytic solutions to top academic centers, hospital systems, associations, and healthcare providers. About Tempus: Tempus is a technology company that is building the world’s largest library of molecular and clinical data and an operating system to make that data accessible and useful. We enable physicians to deliver personalized cancer care for patients through our interactive analytical and machine learning platform. We provide genomic sequencing services and analyze molecular and therapeutic data to empower physicians to make real-time, data-driven decisions. Our goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as we gather more data. For more information, visit tempus.com.


CHICAGO, May 24, 2017 (GLOBE NEWSWIRE) -- Dr. Andrea Califano, a pioneer in cancer systems biology and a renowned researcher at Columbia University, has joined the Tempus Scientific Advisory Board. In this role, he will serve as an advisor to the company and will bring his decades of experience researching the clinical implications of how DNA mutations and RNA expression levels interact at the proteomic level. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/41e3b884-5da3-4ca3-be81-004d958c132b “I have spent my career working to determine the genetic drivers of cancer and believe that with the intersection of science and technology, we are on the verge of transforming the way cancer care is delivered,” said Dr. Andrea Califano. “I am excited to join the Scientific Board at Tempus and to help them accelerate the broad application of data in both the research and clinical environment.” Dr. Califano is the Clyde and Helen Wu Professor of Chemical Systems Biology at Columbia University Medical Center. He is the Founding Chair of the Department of Systems Biology, Director of the JP Sulzberger Columbia Genome Center, and Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center, and also holds appointments in the Department of Biochemistry & Molecular Biophysics and Department of Biomedical Informatics. He joins the board along with Dr. Arul M. Chinnaiyan and Dr. David Agus. Meanwhile, DarwinHealth, a precision focused cancer medicine company, co-founded by Dr. Califano, that uses RNA analysis in an effort to match patients with treatments has partnered with Tempus on a personalized medicine research initiative aimed at improving outcomes for patients diagnosed with cancer. As part of the collaboration, Tempus will use information obtained from DarwinHealth reports in conjunction with approximately 2,000 de-identified patients for whom Tempus has done genetic sequencing of normal, tumor DNA and RNA in an effort to further explore protein interactions and tumor growth. The collaboration with DarwinHealth, using a systems biology approach to cancer care, will leverage the deep molecular and clinical data that Tempus collects daily, and the algorithms that Andrea has developed over the last decade, to help determine the driving force behind various cancers. “At Tempus, we are on a mission to recruit the best and brightest minds in cancer to help shape and guide the future of cancer treatment,” said Eric Lefkofsky, Co-founder and CEO at Tempus. “This partnership is consistent with that commitment as both Andrea and DarwinHealth are pioneering new ways to explore protein interactions that might open the door to an entirely new class of therapeutics.” Tempus provides molecular sequencing and clinical analytic solutions to top academic centers, hospital systems, associations, and healthcare providers. About Tempus: Tempus is a technology company that is building the world’s largest library of molecular and clinical data and an operating system to make that data accessible and useful. We enable physicians to deliver personalized cancer care for patients through our interactive analytical and machine learning platform. We provide genomic sequencing services and analyze molecular and therapeutic data to empower physicians to make real-time, data-driven decisions. Our goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as we gather more data. For more information, visit tempus.com.


CHICAGO, May 24, 2017 (GLOBE NEWSWIRE) -- Dr. Andrea Califano, a pioneer in cancer systems biology and a renowned researcher at Columbia University, has joined the Tempus Scientific Advisory Board. In this role, he will serve as an advisor to the company and will bring his decades of experience researching the clinical implications of how DNA mutations and RNA expression levels interact at the proteomic level. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/41e3b884-5da3-4ca3-be81-004d958c132b “I have spent my career working to determine the genetic drivers of cancer and believe that with the intersection of science and technology, we are on the verge of transforming the way cancer care is delivered,” said Dr. Andrea Califano. “I am excited to join the Scientific Board at Tempus and to help them accelerate the broad application of data in both the research and clinical environment.” Dr. Califano is the Clyde and Helen Wu Professor of Chemical Systems Biology at Columbia University Medical Center. He is the Founding Chair of the Department of Systems Biology, Director of the JP Sulzberger Columbia Genome Center, and Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center, and also holds appointments in the Department of Biochemistry & Molecular Biophysics and Department of Biomedical Informatics. He joins the board along with Dr. Arul M. Chinnaiyan and Dr. David Agus. Meanwhile, DarwinHealth, a precision focused cancer medicine company, co-founded by Dr. Califano, that uses RNA analysis in an effort to match patients with treatments has partnered with Tempus on a personalized medicine research initiative aimed at improving outcomes for patients diagnosed with cancer. As part of the collaboration, Tempus will use information obtained from DarwinHealth reports in conjunction with approximately 2,000 de-identified patients for whom Tempus has done genetic sequencing of normal, tumor DNA and RNA in an effort to further explore protein interactions and tumor growth. The collaboration with DarwinHealth, using a systems biology approach to cancer care, will leverage the deep molecular and clinical data that Tempus collects daily, and the algorithms that Andrea has developed over the last decade, to help determine the driving force behind various cancers. “At Tempus, we are on a mission to recruit the best and brightest minds in cancer to help shape and guide the future of cancer treatment,” said Eric Lefkofsky, Co-founder and CEO at Tempus. “This partnership is consistent with that commitment as both Andrea and DarwinHealth are pioneering new ways to explore protein interactions that might open the door to an entirely new class of therapeutics.” Tempus provides molecular sequencing and clinical analytic solutions to top academic centers, hospital systems, associations, and healthcare providers. About Tempus: Tempus is a technology company that is building the world’s largest library of molecular and clinical data and an operating system to make that data accessible and useful. We enable physicians to deliver personalized cancer care for patients through our interactive analytical and machine learning platform. We provide genomic sequencing services and analyze molecular and therapeutic data to empower physicians to make real-time, data-driven decisions. Our goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as we gather more data. For more information, visit tempus.com.


CHICAGO, May 24, 2017 (GLOBE NEWSWIRE) -- Dr. Andrea Califano, a pioneer in cancer systems biology and a renowned researcher at Columbia University, has joined the Tempus Scientific Advisory Board. In this role, he will serve as an advisor to the company and will bring his decades of experience researching the clinical implications of how DNA mutations and RNA expression levels interact at the proteomic level. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/41e3b884-5da3-4ca3-be81-004d958c132b “I have spent my career working to determine the genetic drivers of cancer and believe that with the intersection of science and technology, we are on the verge of transforming the way cancer care is delivered,” said Dr. Andrea Califano. “I am excited to join the Scientific Board at Tempus and to help them accelerate the broad application of data in both the research and clinical environment.” Dr. Califano is the Clyde and Helen Wu Professor of Chemical Systems Biology at Columbia University Medical Center. He is the Founding Chair of the Department of Systems Biology, Director of the JP Sulzberger Columbia Genome Center, and Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center, and also holds appointments in the Department of Biochemistry & Molecular Biophysics and Department of Biomedical Informatics. He joins the board along with Dr. Arul M. Chinnaiyan and Dr. David Agus. Meanwhile, DarwinHealth, a precision focused cancer medicine company, co-founded by Dr. Califano, that uses RNA analysis in an effort to match patients with treatments has partnered with Tempus on a personalized medicine research initiative aimed at improving outcomes for patients diagnosed with cancer. As part of the collaboration, Tempus will use information obtained from DarwinHealth reports in conjunction with approximately 2,000 de-identified patients for whom Tempus has done genetic sequencing of normal, tumor DNA and RNA in an effort to further explore protein interactions and tumor growth. The collaboration with DarwinHealth, using a systems biology approach to cancer care, will leverage the deep molecular and clinical data that Tempus collects daily, and the algorithms that Andrea has developed over the last decade, to help determine the driving force behind various cancers. “At Tempus, we are on a mission to recruit the best and brightest minds in cancer to help shape and guide the future of cancer treatment,” said Eric Lefkofsky, Co-founder and CEO at Tempus. “This partnership is consistent with that commitment as both Andrea and DarwinHealth are pioneering new ways to explore protein interactions that might open the door to an entirely new class of therapeutics.” Tempus provides molecular sequencing and clinical analytic solutions to top academic centers, hospital systems, associations, and healthcare providers. About Tempus: Tempus is a technology company that is building the world’s largest library of molecular and clinical data and an operating system to make that data accessible and useful. We enable physicians to deliver personalized cancer care for patients through our interactive analytical and machine learning platform. We provide genomic sequencing services and analyze molecular and therapeutic data to empower physicians to make real-time, data-driven decisions. Our goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as we gather more data. For more information, visit tempus.com.


CHICAGO, May 24, 2017 (GLOBE NEWSWIRE) -- Dr. Andrea Califano, a pioneer in cancer systems biology and a renowned researcher at Columbia University, has joined the Tempus Scientific Advisory Board. In this role, he will serve as an advisor to the company and will bring his decades of experience researching the clinical implications of how DNA mutations and RNA expression levels interact at the proteomic level. A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/41e3b884-5da3-4ca3-be81-004d958c132b “I have spent my career working to determine the genetic drivers of cancer and believe that with the intersection of science and technology, we are on the verge of transforming the way cancer care is delivered,” said Dr. Andrea Califano. “I am excited to join the Scientific Board at Tempus and to help them accelerate the broad application of data in both the research and clinical environment.” Dr. Califano is the Clyde and Helen Wu Professor of Chemical Systems Biology at Columbia University Medical Center. He is the Founding Chair of the Department of Systems Biology, Director of the JP Sulzberger Columbia Genome Center, and Associate Director for Bioinformatics of the Herbert Irving Comprehensive Cancer Center, and also holds appointments in the Department of Biochemistry & Molecular Biophysics and Department of Biomedical Informatics. He joins the board along with Dr. Arul M. Chinnaiyan and Dr. David Agus. Meanwhile, DarwinHealth, a precision focused cancer medicine company, co-founded by Dr. Califano, that uses RNA analysis in an effort to match patients with treatments has partnered with Tempus on a personalized medicine research initiative aimed at improving outcomes for patients diagnosed with cancer. As part of the collaboration, Tempus will use information obtained from DarwinHealth reports in conjunction with approximately 2,000 de-identified patients for whom Tempus has done genetic sequencing of normal, tumor DNA and RNA in an effort to further explore protein interactions and tumor growth. The collaboration with DarwinHealth, using a systems biology approach to cancer care, will leverage the deep molecular and clinical data that Tempus collects daily, and the algorithms that Andrea has developed over the last decade, to help determine the driving force behind various cancers. “At Tempus, we are on a mission to recruit the best and brightest minds in cancer to help shape and guide the future of cancer treatment,” said Eric Lefkofsky, Co-founder and CEO at Tempus. “This partnership is consistent with that commitment as both Andrea and DarwinHealth are pioneering new ways to explore protein interactions that might open the door to an entirely new class of therapeutics.” Tempus provides molecular sequencing and clinical analytic solutions to top academic centers, hospital systems, associations, and healthcare providers. About Tempus: Tempus is a technology company that is building the world’s largest library of molecular and clinical data and an operating system to make that data accessible and useful. We enable physicians to deliver personalized cancer care for patients through our interactive analytical and machine learning platform. We provide genomic sequencing services and analyze molecular and therapeutic data to empower physicians to make real-time, data-driven decisions. Our goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as we gather more data. For more information, visit tempus.com.


April 24, 2017 -- In newly updated clinical guidelines from the Society for Integrative Oncology (SIO), researchers at Columbia University's Mailman School of Public Health and the Herbert Irving Comprehensive Cancer Center with an interdisciplinary team of colleagues at MD Anderson Cancer Center, University of Michigan, Memorial Sloan Kettering Cancer Center, and other institutions in the U.S. and Canada, analyzed which integrative treatments are most effective and safe for patients with breast cancer. This systematic review adds to the growing literature on integrative therapies for patients with breast cancer and other cancer populations. The latest results are published online and in print in CA: A Cancer Journal for Clinicians, a publication of the American Cancer Society. The researchers evaluated more than 80 different therapies and developed grades of evidence. Based on those findings, the Society for Integrative Oncology makes the following recommendations: "Studies show that up to 80 percent of people with a history of cancer use one or more complementary and integrative therapies, but until recently, evidence supporting the use of many of these therapies had been limited," said Heather Greenlee, ND, PhD, assistant professor of Epidemiology at Columbia University's Mailman School of Public Health, and past president of SIO. "Our goal is to provide clinicians and patients with practical information and tools to make informed decisions on whether and how to use a specific integrative therapy for a specific clinical application during and after breast cancer treatment," Greenlee continues. In their systematic evaluation of peer-reviewed randomized clinical trials, the researchers assigned letter grades to therapies based on the strength of evidence. A letter grade of "A" indicates that a specific therapy is recommended for a particular clinical indication, and there is high certainty of substantial benefit for the patient. Meditation had the strongest evidence supporting its use, and is recommended for reducing anxiety, treating symptoms of depression, and improving quality of life, based on results from five trials. Music therapy, yoga, and massage received a B grade for the same symptoms, as well as for providing benefits to breast cancer patients. Yoga received a B grade for improving quality of life based on two recent trials. Yoga and hypnosis received a C for fatigue. "The routine use of yoga, meditation, relaxation techniques, and passive music therapy to address common mental health concerns among patients with breast cancer is supported by high levels of evidence," said Debu Tripathy, MD, chair of Breast Oncology at The University of Texas MD Anderson Cancer Center, and a past president of SIO. "Given the indication of benefit coupled with the relatively low level of risk, , these therapies can be offered as a routine part of patient care, especially when symptoms are not well controlled." Acupressure and acupuncture received a B grade as an addition to drugs used for reducing chemotherapy-induced nausea and vomiting. In general, there was a lack of strong evidence supporting the use of ingested dietary supplements and botanical natural products as part of supportive cancer care and to manage treatment-related side effects. "Clinicians and patients need to be cautious about using therapies that received a grade of C or D and fully understand the potential risks of not using a conventional therapy that may effectively treat cancer or help manage side effects associated with cancer treatment," warned Lynda Balneaves, RN, PhD, associate professor, College of Nursing, Rady Faculty of Health Sciences, Winnipeg, Canada, and president-elect of SIO. "Patients are using many forms of integrative therapies with little or no supporting evidence and that remain understudied," noted Dr. Greenlee. "This paper serves as a call for further research to support patients and healthcare providers in making more informed decisions that achieve meaningful clinical results and avoid harm." Additional co-authors: Melissa J. DuPont-Reyes, Department of Epidemiology, Mailman School of Public Health, Columbia University; Linda Carlson, Department of Oncology, University of Calgary, Calgary, AB, Canada; Misha Cohen, American College of Traditional Chinese Medicine at California Institute of Integral Studies, and Chicken Soup Chinese Medicine, San Francisco; Gary Deng, Integrative Oncology, Memorial Sloan Kettering Cancer Center, New York City; Jillian A. Johnson, Department of Biobehavioral Health, The Pennsylvania State University, University Park; Matthew Mumber, Department of Radiation Oncology,Harbin Clinic, Rome, GA; Dugald Seely, Ottawa Integrative Cancer Center, Ottawa, ON, and Canadian College of Naturopathic Medicine, Toronto, ON; Suzanna M. Zick, Department of Family Medicine, University of Michigan Health System, and Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor; and Lindsay M. Boyce, Memorial Sloan Kettering Library, Memorial Sloan Kettering Cancer Center, New York City. Founded in 1922, Columbia University's Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 450 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,300 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Mailman School is also home to numerous world-renowned research centers including ICAP (formerly the International Center for AIDS Care and Treatment Programs) and the Center for Infection and Immunity. For more information, please visit http://www. .

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