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Kim S.K.,Kyung Hee University | Chung J.-H.,Kyung Hee University | Park H.C.,Kyung Hee University | Kim J.H.,Kyung Hee University | And 6 more authors.
Experimental and Therapeutic Medicine | Year: 2015

Estrogens and estrogen receptors (ESRs) have been implicated in the stimulation of aberrant prostate growth and the development of prostate diseases. The aim of the present study was to investigate four single nucleotide polymorphisms (SNPs) of the ESR2 gene in order to examine whether ESR2 is a susceptibility gene for benign prostatic hyperplasia (BPH). In order to evaluate whether an association exists between ESR2 and BPH risk, four polymorphisms [rs4986938 (intron), rs17766755 (intron), rs12435857 (intron) and rs1256049 (Val328Val)] of the ESR2 gene were genotyped by direct sequencing. A total of 94 patients with BPH and 79 control subjects were examined. SNPStats and Haploview version 4.2 we used for the genetic analysis. Multiple logistic regression models (codominant1, codominant2, dominant, recessive and log‑additive) were produced in order to obtain the odds ratio, 95% confidence interval and P‑value. Three SNPs (rs4986938, rs17766755 and rs12435857) showed significant associations with BPH (rs4986938, P=0.015 in log‑additive model; rs17766755, P=0.033 in codominant1 model, P=0.019 in dominant model and P=0.020 in log‑additive model; rs12435857, P=0.023 in dominant model and P=0.011 in log‑additive model). The minor alleles of these SNPs increased the risk of BPH, and the AAC haplotype showed significant association with BPH (χ2=6.34, P=0.0118). These data suggest that the ESR2 gene may be associated with susceptibility to BPH. © 2015, Spandidos Publications. All rights reserved. Source


Chung I.-M.,Konkuk University | Ali M.,Hamdard University | Hong Y.-P.,Herbal Crop Utilization Research Team | Ahmad A.,Konkuk University
Asian Journal of Chemistry | Year: 2013

One new compound dammar-9(11),24-dien-3b-ol-3a-L-arabinosyl-7a-octanoate along with the known compound b-sitosterol-b-Dglucoside were isolated and identified from the heat processed roots of Panax ginseng. The chemical structure of new compound was elucidated by 1D and 2D NMR spectroscopic techniques (COSY, HSQC, HMBC) aided by FAB-MS and IR spectra. Source


Chung I.-M.,Konkuk University | Ali M.,Hamdard University | Yang Y.-S.,Konkuk University | Yoon J.-Y.,Konkuk University | And 2 more authors.
Journal of Chemistry | Year: 2013

Two new compounds stigmasta-3α-ol-3α-(2′R,3′S)- butane-1′,2′,3′,4′-tetraolyl-2′, 3′-dioctadec-9″/9‴-enoyl-4′- octadec-9′‴,12′‴-dienoate (1) and stigmasta-5-en-3β-ol-3β-(2′R,3′S)-butane-1′, 2′,3′,4′-tetraolyl-2′,3′-dioctadec-9 ″/9‴-enoyl-4′-octadec-9 ′,12′-dienoate (2) along with β-sitosterol-β-D-glucoside were isolated and identified from the heat processed roots of Panax ginseng. The structures of the new compounds were elucidated by 1D and 2D NMR (COSY, HSQC, and HMBC) spectroscopic techniques aided by FAB-MS, ESI FT/MS, and IR spectra. © 2013 Ill-Min Chung et al. Source


Chung I.-M.,Konkuk University | Kim M.-Y.,Konkuk University | Praveen N.,Konkuk University | Hong Y.-P.,Herbal Crop Utilization Research Team | Ahmad A.,Konkuk University
Asian Journal of Chemistry | Year: 2013

One compound n-tetratriacont-20,23-dienoic acid (1) along with β-sitosterol-β-D-glucopyranoside were isolated and identified from the heat processed roots of Panax ginseng. The structure of compound was elucidated with the help of 600 MHz NMR using 1D and 2D NMR (COSY, HSQC and HMBC) spectroscopic techniques aided by FABMS and IR spectra. The n-tetratriacont-20, 23-dienoic acid (1) is reported for the first time from the roots of Panax ginseng. Source

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