Iio E.,Nagoya City University |
Iio E.,Hepatitis Glyco biomarker Study Group |
Ocho M.,Japan National Institute of Advanced Industrial Science and Technology |
Ocho M.,Hepatitis Glyco biomarker Study Group |
And 24 more authors.
International Journal of Cancer | Year: 2016
Recently, we identified a novel liver fibrosis glycobiomarker, Wisteria floribunda agglutinin (WFA)-reactive colony stimulating factor 1 receptor (WFA+-CSF1R), using a glycoproteomics-based strategy. The aim of this study was to assess the value of measuring WFA+-CSF1R levels for the prognosis of carcinogenesis and outcome in liver cirrhosis (LC) patients with hepatitis C virus (HCV). WFA+-CSF1R and Total-CSF1R levels were measured in serum samples from 214 consecutive HCV-infected patients to evaluate their impact on carcinogenesis and the survival of LC patients. Serum WFA+-CSF1R levels were significantly higher in LC patients than chronic hepatitis (CH) patients (p < 0.001). The AUC of WFA+-CSF1R for predicting overall survival, calculated by time-dependent ROC analysis, was 0.691 and the HR (per 1-SD increase) was 1.80 (95% CI, 1.23-2.62, p < 0.001). Furthermore, the survival rate of LC patients with high WFA+-CSF1R levels (≥310 ng/ml) was significantly worse than those with lower levels (p < 0.01). The AUC of WFA+/total-CSF1R percentage (WFA+-CSF1R%) for predicting the cumulative carcinogenesis rate was 0.760, with an HR of 1.66 (95% CI 1.26-2.20, p < 0.001). In fact, the carcinogenesis rate was significantly higher in LC patients with a high WFA+-CSF1R% (≥ 35%, p = 0.006). Assessing serum levels of WFA+-CSF1R has diagnostic value for predicting carcinogenesis and the survival of LC patients. What's new? To find better biomarkers of liver fibrosis the authors developed a novel assay to detect serum levels of Wisteria floribunda agglutinin (WFA)-reactive colony-stimulating factor 1 receptor (WFA+ -CSF1R). CSF1R is a membrane glycoprotein associated with cell proliferation and found elevated in a variety of cancers. They report that in hepatitis C virus-infected patients who developed liver cirrhosis, the survival rate of patients with high WFA+-CSF1R levels was significantly worse. Similarly, the carcinogenesis rate was higher in patients with high percentage of WFA+-CSF1R, suggesting that this glycobiomarker may have clinical applications beyond the mere evaluation of liver fibrosis. © 2015 UICC.