Frederick, MD, United States

The Henry M. Jackson Foundation for the Advancement of Military Medicine is a private, not-for-profit organization established in 1983 and authorized by Congress to support medical research and education at the Uniformed Services University of the Health science and throughout the military medical community. The Foundation was named in honor of Washington State Senator Henry "Scoop" Jackson, who sponsored the original legislation. Senator Jackson had a long-standing commitment to military medicine and health.HJF provides scientific and management services, from infrastructure development, financial administration and clinical trials management to staffing, continuing medical education and event planning. The Foundation works with a variety of programs, from large multi-site trials to small, benchtop projects, both nationally and abroad. USU, located in Bethesda, Maryland, is the nation’s only federal school of medicine and graduate school of nursing. It was established by Congress in 1972. The University’s curriculum is similar to that of its civilian counterparts, but it also provides additional specialized education elements geared towards producing career uniformed officers. USU was a major focus of the documentary film Fighting for Life, which was released in 2008.HJF’s largest program is the U.S. Military HIV Research Program , whose mission is to protect U.S. military personnel and aid the international fight against HIV. Established in 1988, the program focuses on HIV vaccine development, prevention, disease surveillance and care and treatment for HIV.The Foundation supports more than 1,000 additional research projects at USU and throughout military medicine, including the Center for Prostate Disease Research, the Navy Biological Defense Directorate, the Center for the Study of Traumatic Stress and the Center for Disaster and Humanitarian Assistance Medicine. It employs more than 2,400 scientific, medical, management and administrative personnel. HJF also manages endowments for USU and promotes government-civilian partnerships through its Center for Public-Private Partnerships Wikipedia.


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Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2015-03-12

Alterations to the ERG gene are some of the most prominent genomic changes associated with many cancers including prostate cancer. Such cancer specific alterations result in the overexpression of wild type ERG protein or an altered ERG protein. The present invention provides selective inhibitors of wild type or an altered ERG protein expression. The ERG inhibitors of the invention, therefore, are therapeutic agents for treating ERG positive cancers.


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2015-04-21

The present invention provides for methods of measuring levels of micro RNAs for the diagnosis, treatment and/or monitoring the progression of post-traumatic stress disorder (PTSD) or traumatic brain injury (TBI) in a subject having or suspected of having PTSD and/or TBI. The methods, in general comprise measuring levels of at least one of miR-142-5p, miR-19b, miR-1928, miR-223-3p, miR-322*, miR-324, miR-421-3p, miR-463* and miR-674* is a sample from a subject suffering from or suspected of having PTSD and/or TBI.


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2016-11-14

The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2016-05-05

Provided are methods of using polycarbonate filters to isolate and detect cancer cells in a biological fluid, particularly biological fluids, such as urine, that contain very low concentrations of cancer cells. The characterization of the isolated cells for the presence or absence of cancer specific proteins is useful for cancer diagnosis and prognosis


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2017-01-18

This invention relates to soluble forms of F glycoprotein from Hendra and Nipah virus and to compositions comprising soluble forms of F glycoprotein from Hendra and Nipah virus. This invention further relates to soluble oligomers of F glycoprotein from Hendra and Nipah virus. This invention also relates to nucleic acids encoding soluble forms of F glycoprotein from Hendra and Nipah virus. This invention also relates to diagnostic and therapeutic methods using the soluble forms of F glycoprotein from Hendra and Nipah virus. Further, this invention relates to antibodies, including neutralizing antibodies, and to vaccines for the prevention, diagnosis and treatment of infection by Hendra and Nipah viruses.


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2016-05-18

The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2016-07-14

A manually operable pump for the effective removal of fluids to include blood, blood clots, fluid, and air from a body cavity of a subject is provided. The manually operable pump is adapted to be connect to a range of fluid conduits and is equipped with one-way valves that effectively permit flow of fluid through the pump in only one direction. The sensitivity of the one-way valves is such that when properly positioned, fluid can flow through the valves and out of the pump without manual compression of the pump and with the aid of gravity power alone.


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2015-01-23

The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and/or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and/or compositions of the invention.


Patent
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc | Date: 2016-03-11

Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm. The magnetic region can serve to attract and position both residual red blood cells and magnetically nano-treated growth-promoting cells to the orifice area of the aneurysm. The outer circumference of the tubular elongated body can act as a floor or scaffold for regenerated smooth vascular muscle cells. In embodiments, the tissue nidus area can be provided on the exterior stent, while the magnetized region is provided on the interior stent, of a stent-in-stent structure. In embodiments, the exterior stent is made of biodegradable material which gradually dissolves or dissipates in situ.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 149.38K | Year: 2015

The objective of this project is to develop a Multi-Input Multi-Output (MIMO) aware cooperative Dynamic Spectrum Access framework, termed McDysa, which enables multiple primary users and multiple secondary users to cooperate in dynamic spectrum sharing. By exploiting the underlying cognitive radio and MIMO techniques, McDysa is expected to achieve significant gains on spectrum efficiency while providing substantial enhancements to physical layer security as well. The technical merit and impact of this project are both fundamental and applied, including new problems, algorithms, and methodologies. The McDysa architecture considers multiple simultaneous primary- and secondary-user transmissions by exploiting MIMO techniques. A number of problems studied in the project may foster the development of novel techniques and methodologies toward MIMO-aware dynamic spectrum access. Examples include the novel problem of MIMO-enabled relay selection, insightful analysis of McDysa transmission capacity, and the consideration of secrecy capacity enhancement via friendly jamming. As many of the methodologies in McDysa leverage knowledge from other domains such as game theory, the research outcomes of this project may also motivate advancements of the corresponding domain-specific research. The broader impact of this project also extends to education. The project contains a detailed plan for disseminating the research results and for outreaching to students from underrepresented groups via various channels established in the past years. It also includes a plan for integrating undergraduate and graduate education with research through curriculum development and student involvement. Specifically, the testbed validation of McDysa can offer undergraduate and graduate students valuable hands-on experience, and is therefore an excellent educational vehicle to broaden the participation of students, especially those from underrepresented groups, in computer science research.

Technically, this project defines novel problems and develops new performance-optimization techniques in the following three thrusts that are critical to MIMO-aware cooperative dynamic spectrum access: (i) Relay selection and resource sharing, which focuses on developing novel centralized and distributed relay selection and resource management algorithms based on game theory to enable multiple MIMO-empowered primary and secondary users to cooperate for joint optimization. (ii) Achievable transmission capacity analysis, which investigates the achievable transmission capacity of secondary networks and secrecy capacity of the primary network, and the usage of beamforming optimization to maximize such capacities. (iii) Secrecy capacity enhancement, which studies the usage of two friendly jamming mechanisms, cooperative jamming and artificial interference, in the design of novel beamforming techniques and interference signals for nulling the interference at the receivers, in order to enhance the secrecy capacity of the primary network. Besides the three thrusts, this project also includes the design and validation of a testbed that supports a number of experimental tasks for validating the effectiveness of approaches and methodologies developed in the project. This project also has strong societal impact as the rigorously proven solutions developed in the project can serve as guidelines and backbone for promoting and establishing more flexible spectrum access policies and regulations.

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