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Hartford, CT, United States

Ballard K.D.,Henry Low Heart Center | Bruno R.S.,Ohio State University
Nutrition Reviews | Year: 2015

Greater intakes of dairy are frequently associated with reduced risk of cardiovascular disease. These observational studies have served as the basis for controlled interventions aimed at defining the cardioprotective mechanisms of dairy. Understanding these relationships is of public health importance because most of the US population fails to meet dietary recommendations for dairy, suggesting that many individuals could lower their cardiovascular disease risk by relatively simple dietary modification. Clinical studies investigating the acute ingestion of dairy or its constituents, including short-term (≤2 week) supplementation studies or those assessing postprandial responses, have largely shown benefits on vascular function without concomitant improvements in blood pressure. Chronic interventions have been less conclusive, with some showing benefits and others indicating a lack of improvement in vascular function regardless of blood pressure changes. Vasoprotective activities of dairy are likely mediated through improvements in nitric oxide bioavailability, oxidative stress, inflammation, and insulin resistance. Future controlled studies are needed to determine if these health benefits are mediated directly by dairy or indirectly by displacing other dietary components that otherwise impair vascular health. © The Author(s) 2014. Source


Krishnan G.M.,University of Connecticut | Thompson P.D.,Henry Low Heart Center
Current Opinion in Lipidology | Year: 2010

PURPOSE OF REVIEW: HMG-CoA reductase inhibitors or statins are associated with a variety of muscle side-effects but little is known about the effect of statins on skeletal muscle strength and exercise performance. We performed a literature search to examine these issues. RECENT FINDINGS: We identified six studies examining the effect of statins on muscle strength and nine studies examining their effect on exercise tolerance. In general, studies examining both issues were small and used crude measures of strength and exercise performance. SUMMARY: There is insufficient data to determine if statins affect muscle strength and exercise performance. There is suggestive evidence that these drugs may reduce muscle strength in older patients and alter energy metabolism during aerobic exercise, both possibilities require further study. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source


Rosenson R.S.,Mount Sinai School of Medicine | Baker S.K.,McMaster University | Jacobson T.A.,Emory University | Kopecky S.L.,Mayo Medical School | Parker B.A.,Henry Low Heart Center
Journal of Clinical Lipidology | Year: 2014

The National Lipid Association's Muscle Safety Expert Panel was charged with the duty of examining the definitions for statin-associated muscle adverse events, development of a clinical index to assess myalgia, and the use of diagnostic neuromuscular studies to investigate muscle adverse events. We provide guidance as to when a patient should be considered for referral to neuromuscular specialists and indications for the performance of a skeletal muscle biopsy. Based on this review of evidence, we developed an algorithm for the evaluation and treatment of patients who may be intolerant to statins as the result of adverse muscle events. The panel was composed of clinical cardiologists, clinical lipidologists, an exercise physiologist, and a neuromuscular specialist. © Published by Elsevier Inc. on behalf of National Lipid Association. Source


Thompson P.D.,Henry Low Heart Center
Undersea and Hyperbaric Medicine | Year: 2011

Cardiovascular disease may be responsible for a quarter of diving fatalities, but there are few studies on the cardiovascular complications of this activity. In contrast, there is a rich literature on land-based, exercise-related cardiac events. These studies document that exercise can increase the risk of acute cardiac events, but that absolute risk is small for healthy individuals. There are no proven strategies to reduce exercise-related cardiac events and consequently no proven strategies that could be confidently applied to diving. Nevertheless, requiring a pre-diving medical evaluation and clearance for those with known cardiac disease, training dive personnel to elicit possible cardiac prodromal symptoms, and frequent emergency training for diving supervisors are prudent approachs to this problem. Copyright © 2011 Undersea & Hyperbaric Medical Society, Inc. Source


Gowd B.M.P.,Henry Low Heart Center | Heller G.V.,Morristown Medical Center | Parker M.W.,Henry Low Heart Center
Journal of Nuclear Cardiology | Year: 2014

Myocardial perfusion imaging (MPI) has enjoyed considerable success for decades due to its diagnostic accuracy and wealth of prognostic data. Despite this success several limitations such as lengthy protocols and radiation exposure remain. Advancements to address these shortcomings include abbreviated stress-only MPI (SO MPI) protocols, PET and both hardware and software methods to reduce radiation exposure and time. SO MPI has advantages in protocol time and radiation reduction with a wealth of supporting data in terms of diagnostic validity and prognostic value. Newer technologies such as attenuation correction, and advanced camera technologies have enabled SO MPI to be more efficient in reducing the time of acquisition and radiation dose and improving accuracy. This review examines the literature available, regarding accuracy, patient outcomes, implementation strategies, and newer developments associated with SO MPI. © 2014, American Society of Nuclear Cardiology. Source

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