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Qin Y.-L.,Nanjing Southeast University | Deng G.,Nanjing Southeast University | Li T.-X.,Henan Provincial Peoples Hospital | Jing R.-W.,Nanjing Southeast University | Teng G.-J.,Nanjing Southeast University
Journal of Vascular Surgery | Year: 2012

Objective: This study evaluated the risk factors of incomplete thrombosis in the false lumen after thoracic endovascular aortic repair (TEVAR) in patients with extensive acute type B aortic dissection. Methods: This was a retrospective study at Zhongda Hospital and Henan Provincial People's Hospital, China. Between January 2005 and May 2008, patients with acute type B dissection who underwent TEVAR at two centers were reviewed and 124 who met the following criteria were included in this study: (1) dissection involving the aorta below the level of the celiac artery, (2) completely patent false lumen at the time of intervention, and (3) complete initial diagnostic computed tomography (CT) scans and all follow-up CT scans available. Exclusion criteria were (1) aortic dissection secondary to trauma, (2) intramural hematoma, and (3) Marfan patients. The main outcome measures were demographics, comorbidity profiles, technical details of procedures, anatomic characteristics of dissection, and false lumen status of thrombosis during follow-up. Ordinal regression analysis was performed with variables that reached P <.20 on univariate analysis to investigate independent risk factors of incomplete thrombosis in the false lumen. Results: Univariate analysis showed that the age at TEVAR, hypertension, maximum diameter of the abdominal aorta and false lumen at the abdominal level, re-entry tears, and visceral branches that arose partially or totally from the false lumen had a P <.20. Further analysis with an ordinal regression model showed that the visceral branches that arose partially or totally from the false lumen (odds ratio [OR], 10.054; P <.001), re-entry tears (OR, 30.661; P <.001), and maximum diameter of the false lumen on the abdominal aorta (OR, 1.265; P =.004) were the significant risk factors of incomplete thrombosis in the false lumen after TEVAR. Conclusions: Visceral branches that arose partially or totally from the false lumen, re-entry tears, and maximum diameter of the false lumen on the abdominal aorta were the risk factors of incomplete thrombosis in the false lumen after TEVAR in extensive acute type B dissection. © 2012 Society for Vascular Surgery.

Kang S.S.,Henan Provincial Peoples Hospital
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2012

To explore the method of repairing segmental ear helix defect. Twenty-one patients with segmental ear helix defect were repaired with post-auricular skin flap. In the first stage operation, ear helix defect was assessed, including the anterior and posterior area defect. According to the defect, post-auricular skin flap was designed and transplanted to repair the defect. Six weeks later, the pedicle of the post-auricular skin flap was cut off, elevated, and folded to form the helix. The secondary defect was directly sutured or repaired with skin graft. Twenty-one patients were treated with this method. In two to 12 months follow-up, all flaps survived and reconstructed ear helices were in good shape. The reconstructed ears were in symmetry to the healthy ones. The method is safe and effective for the correction of segmental ear helix defect.

Pan J.-B.,Henan Provincial Peoples Hospital | Hou Y.-H.,Zhengzhou University | Zhang G.-J.,Zhengzhou University
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: Mutations affecting the epidermal growth factor receptor (EGFR) are good predictors of clinical efficacy of EGFR tyrosine kinase inhibitors (TKI) in patients with non-small cell lung cancer. Serum carcinoembryonic antigen (CEA) levels are also regarded as predictive for the efficacy of EGFR-TKI and EGFR gene mutations. This study analyzed the association between EGFR gene mutations and clinical features, including serum tumor marker levels in lung adenocarcinomas patients. Patients and Methods: A total of 70 lung adenocarcinoma patients with complete clinical data and pathological specimens were investigated. EGFR gene mutations at exons 19 and 21 were assessed. Serum tumor markers were detected by protein chipchemiluminescence at the corresponding time, and correlations were analyzed. Results: Mutations of the EGFR gene were detected in 27 of the 70 patients and the serum CEA and CA242 concentrations were found to be significantly associated with the incidence of EGFR gene mutations (P<0.05). The AUCs for CEA and CA242 were 0.724 (95% CI: 0.598~0.850, P<0.05) and 0.769 (95% CI: 0.523~0.800, P<0.05) respectively. Conclusions: Serum CEA and CA242 levels are associated with mutations of the EGFR gene in patients with lung adenocarcinomas.

Emlet D.R.,Stanford University | Gupta P.,Stanford University | Holgado-Madruga M.,University of Salamanca | Del Vecchio C.A.,Whitehead Institute For Biomedical Research | And 8 more authors.
Cancer Research | Year: 2014

The relationship between mutated proteins and the cancer stem-cell population is unclear. Glioblastoma tumors frequently express EGFRvIII, an EGF receptor (EGFR) variant that arises via gene rearrangement and amplification. However, expression of EGFRvIII is restricted despite the prevalence of the alteration. Here, we show that EGFRvIII is highly coexpressed with CD133 and that EGFRvIII+/CD133+ defines the population of cancer stem cells (CSC) with the highest degree of self-renewal and tumor-initiating ability. EGFRvIII+ cells are associated with other stem/progenitor markers, whereas markers of differentiation are found in EGFRvIII- cells. EGFRvIII expression is lost in standard cell culture, but its expression is maintained in tumor sphere culture, and cultured cells also retain the EGFRvIII+/CD133+ coexpression, self-renewal, and tumor initiating abilities. Elimination of the EGFRvIII+/CD133+ population using a bispecific antibody reduced tumorigenicity of implanted tumor cells better than any reagent directed against a single epitope. This work demonstrates that a mutated oncogene can have CSC-specific expression and be used to specifically target this population. © 2014 American Association for Cancer Research.

Zhang G.-T.,Henan Provincial Peoples Hospital | Zhang X.-D.,Henan Provincial Peoples Hospital
Surgical Laparoscopy, Endoscopy and Percutaneous Techniques | Year: 2013

OBJECTIVE:: To evaluate the feasibility and safety of hand-assisted laparoscopic surgery for gastric cancer in obese patients, we compared the operative outcomes between obese and nonobese patients. METHODS:: A total of 114 patients suffering from gastric cancer operated in our department from October 2009 to February 2012 were divided into 2 groups: the obese patients group and the nonobese patients group. RESULTS:: Wound length, times of analgesic injection, time to the first flatus, postoperative hospital stay, tumor size, retrieved lymph nodes, AJCC/UICC staging, and resection margins were equivalent between the 2 groups. The estimated blood loss and operative time were significantly less or shorter in the nonobese patients group than in the obese patients group. CONCLUSIONS:: Obesity should not be seen as a contraindication for hand-assisted laparoscopic distal gastrectomy, which is a safe and feasible procedure for obese patients. © 2013 by Lippincott Williams and Wilkins.

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