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Han H.-Q.,Shanghai JiaoTong University | Xie B.,Shanghai JiaoTong University | Mu J.-L.,Henan Provincial Mental Hospital | Yang X.-M.,Shanghai JiaoTong University | And 4 more authors.
Journal of Shanghai Jiaotong University (Medical Science) | Year: 2014

Objective: To explore the value of visual P300 potentials in responsible appreciation of schizophrenia patients by judicial expertise. Methods: Sixty-eight schizophrenia patients without responsible ability (group A) and 59 schizophrenia patients with limited responsible ability (group B) by judicial expertise and 58 healthy volunteers (group C) were enrolled in this study. They were given visual P300 potentials test. Results: Compared to group C, latent periods of N1, N2, and P3 of P300 in groups A and B were significantly longer (P<0.01), and the amplitude of P3 decreased markedly (P<0.01). Compared to group B, latent periods of N1, N2, and P3 of P300 in group A were significantly longer, and amplitude of P3 decreased markedly (P<0.01). Conclusion: Visual P300 potentials test has referential meaning in responsible appreciation of schizophrenia by judicial expertise, which needs confirmation by long follow-up. Source


Yan Y.,Xinxiang Medical University | Wang Y.-L.,Xinxiang Medical University | Su Z.,Xinxiang Medical University | Zhang Y.,Xinxiang Medical University | And 6 more authors.
Neuropeptides | Year: 2014

Oxytocin (OXT), a nonapeptide posterior hormone of the pituitary, is mainly synthesized and secreted in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). The present study was to investigate in which level, brain or periphery, OXT effecting on the behavioral activity in the behavioral despair depression rat model. The results showed that (1) either the forced swimming or the tail suspension significantly increased OXT concentration in the brain (PVN, SON, frontal cortex, hippocampus, amygdala, lumbar spinal cord) and in the periphery (posterior pituitary and serum); (2) intraventricular injection (icv) of OXT decreased the animal immobility time, whereas OXT receptor antagonist-desGly-NH2, d(CH2)5[D-Tyr2, Thr-sup-4]OV (icv) increased the animal immobility time in a dose-dependent manner in forced swimming test (FST) and in tail suspension test (TST); (3) neither OXT nor OXT receptor antagonist (intravenous injection) influenced the animal immobility time in FST and in TST. OXT levels were increased in several areas of the brain and in the periphery following the behavioral despair, one stressor, yet pre-treatment with OXT appeared to be beneficial in term of reducing immobility time. The data suggested that behavioral despair could enhance OXT synthesis and secretion not only in the brain but also in the periphery, and OXT in the brain rather than the periphery played a role in the behavioral despair depression. © 2014 Elsevier Ltd. Source


Li H.,Shanghai Mental Health Center | Yao C.,Peking University | Shi J.,Xian Mental Health Center | Yang F.,Beijing HuiLongGuan Hospital | And 12 more authors.
Journal of Psychiatric Research | Year: 2015

This randomized, double-blind study compared the efficacy and safety of blonanserin and risperidone to treat Chinese schizophrenia patients aged ≥18 and < 65 years. Patients with Positive and Negative Syndrome Scale (PANSS) total scores ≥70 and ≤ 120 were randomized to receive blonanserin or risperidone using a gradual dose-titration method (blonanserin tablets: 8-24 mg/day; risperidone tablets: 2-6 mg/day), twice daily. Treatment populations consisted of 128 blonanserin-treated patients and 133 risperidone-treated patients. Intention-to-treat analysis was performed using the last observation carried forward method. Reductions of PANSS total scores by blonanserin and risperidone treatment were -30.59 and -33.56, respectively. Risperidone treatment was associated with elevated levels of serum prolactin (67.16% risperidone versus 52.31% blonanserin) and cardiac-related abnormalities (22.39% risperidone versus 12.31% blonanserin), and blonanserin patients were more prone to extrapyramidal side effects (48.46% blonanserin versus 29.10% risperidone). In conclusion, blonanserin was as effective as risperidone for the treatment of Chinese patients with schizophrenia. The overall safety profiles of these drugs are comparable, although blonanserin was associated with a higher incidence of EPS and risperidone was associated with a higher incidence of prolactin elevation and weight gain. Thus, blonanserin is useful for the treatment of Chinese schizophrenia patients. © 2015 The Authors. Source


Bao L.-L.,153 Hospital of Peoples Liberation Army | Jiang W.-Q.,153 Hospital of Peoples Liberation Army | Sun F.-J.,Xinxiang Institute for New Medicine | Wang D.-X.,Yangzhou University | And 5 more authors.
Neuropeptides | Year: 2014

Psychological stress is strain affecting the intangible self, caused by problems in adaptation, perception, and emotions. Previous studies have demonstrated that arginine vasopressin (AVP) plays an important role in psychological stress. The goal of present study was to investigate the interaction between AVP release and cardiovascular functions by measuring AVP concentration and recording blood pressure or heart rate during psychological stress in human. The results showed that (1) psychological stress not only increased the systolic blood pressure, diastolic blood pressure and heart rate, but also elevated the cortisol and AVP concentration in both plasma and CSF in a stress level-dependent manner; (2) there was a positive relationship between plasma AVP concentration and systolic blood pressure, diastolic blood pressure, heart rate or plasma cortisol concentration; (3) there was also a positive relationship between AVP concentrations in plasma and CSF AVP. The data suggested that plasma AVP, which might come from the central nervous system, might influence the cardiovascular functions during psychological stress in human. © 2014 Elsevier Ltd. Source


Zhang J.-D.,Henan Provincial Mental Hospital | Li W.-Q.,Henan Provincial Mental Hospital | Song X.-H.,Henan Provincial Mental Hospital | Lou B.-Y.,Henan Provincial Mental Hospital | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Adenylate cyclase VIII is involved in the promotion of morphine tolerance, withdrawal and enhancement, and plays an important role in plastic changes, such as the advanced long-term enhancement effect, long-term memory and stress adaptation. OBJECTIVE: To explore the changes of adenylate cyclase VIII gene expression in the shell of accumbens nuclei before and after development of chronic morphine-induced conditioned place aversion in a rat through naloxone reminder addiction withdrawal. METHODS: Clean grade Sprague Dawley rats were divided into three groups: morphine+naloxone group, morphine+saline group and saline+naloxone group. Rats in the former one group received intraperitoneal injection of 10 mg/kg morphine continuously for 6.5 days, and intraperitoneal injection of 0.3 mg/kg naloxone; then the conditioned place aversion model was established combined with the conditioned place training. Rats in the latter two groups were injected with the same dose of saline as the morphine+naloxone group. The adenylate cyclase VIII gene expression in the shell of accumbens nuclei was detected with immunohistochemistry method before and after development of chronic morphine-induced conditioned place aversion model. RESULTS AND CONCLUSION: Before chronic morphine-induced conditioned place aversion model establishment, there was no significant difference of the adenylate cyclase VIII gene expression in the shell of accumbens nuclei (F=4.651, P=0.052); after conditioned place aversion establishement, the adenylate cyclase VIII gene expression in the shell of accumbens nuclei in the morphine+naloxone group was significantly higher than that in the morphine+saline group and saline+naloxone group (F=4.874, P=0.028). The results indicate that the changes of adenylate cyclase VIII gene expression may be one of the important molecular underpinnings of the conditioned place aversion. Source

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