Hemocentro Dalton Barbosa Cunha

Natal, Brazil

Hemocentro Dalton Barbosa Cunha

Natal, Brazil
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Cabral C.H.K.,Federal University of Rio Grande do Norte | Serafim EdvisS.S.,Hemocentro Dalton Barbosa Cunha | de Medeiros W.R.D.B.,Federal University of Rio Grande do Norte | Fernandes T.A.A.M.,Grande Rio University | And 5 more authors.
Genetics and Molecular Biology | Year: 2011

β s haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. © 2011, Sociedade Brasileira de Genética.

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