Hemchandracharya North Gujarat University

Keshorai Patan, India

Hemchandracharya North Gujarat University is a public university in Patan, Gujarat, India. The geographical jurisdiction of the North Gujarat University encompasses four districts: Mehsana, Patan, Banaskantha and Sabarkantha. It is NACC 'B' accredited state university. Wikipedia.

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Patel A.R.,Ganpat University | Prajapati D.S.,Hemchandracharya North Gujarat University | Raval J.A.,Ganpat University
International Journal of Drug Development and Research | Year: 2010

Fast-dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 min when placed in the mouth without drinking water or chewing. More recently, fast-dissolving films are gaining interest as an alternative to fast-dissolving tablets to definitely eliminate patient's fear of chocking and overcome patent impediments. Fast-dissolving films are generally constituted of plasticized hydrocolloids or blends made of thereof that can be laminated by solvent casting or hot-melt extrusion. Thin film drug delivery, also referred to as orally dissolving thin film, and has emerged as an advanced alternative to the traditional tablets, capsules and liquids often associated with prescription and OTC medications. Similar in size, shape and thickness to a postage stamp, thin film strips are typically designed for oral administration, with the person placing the strip on or under the tongue or along the inside of the cheek. Thin film enables the drug to be delivered to the blood stream either intragastrically, buccally or sublingually. The sublingual and buccal delivery of a drug via thin film has the potential to improve the onset of action, lower the dosing, and enhance the efficacy and safety profile of the medicament. The 2-year-old, melt-in-your-mouth delivery system certainly has gained traction among consumers since the 2001 introduction of Pfizer's Listerine Pocket Packs. And now many OTC suppliers are banking on that consumer acceptance as they try to leverage the thin strip technology against a new generation of self-care remedies. There are currently several projects in development that will deliver prescription drugs utilizing the thin film dosage form. © 2010 IJDDR.

Patel B.B.,Hemchandracharya North Gujarat University | Patel B.B.,Evonik Industries | Patel J.K.,Nootan Pharmacy College | Chakraborty S.,Evonik Industries | Shukla D.,Banaras Hindu University
Saudi Pharmaceutical Journal | Year: 2015

Poor solubility and bioavailability of an existing or newly synthesized drug always pose challenge in the development of efficient pharmaceutical formulation. Numerous technologies can be used to improve the solubility and among them amorphous solid dispersion based spray drying technology can be successfully useful for development of product from lab scale to commercial scale with a wide range of powder characteristics. Current review deals with the importance of spray drying technology in drug delivery, basically for solubility and bioavailability enhancement. Role of additives, selection of polymer, effect of process and formulation parameters, scale up optimization, and IVIVC have been covered to gain the interest of readers about the technology. Design of experiment (DoE) to optimize the spray drying process has been covered in the review. A lot more research work is required to evaluate spray drying as a technology for screening the right polymer for solid dispersion, especially to overcome the issue related to drug re-crystallization and to achieve a stable product both in vitro and in vivo. Based on the recent FDA recommendation, the need of the hour is also to adopt Quality by Design approach in the manufacturing process to carefully optimize the spray drying technology for its smooth transfer from lab scale to commercial scale. © 2013 King Saud University.

Patel J.K.,P.A. College | Patel N.K.,Hemchandracharya North Gujarat University
Scientia Pharmaceutica | Year: 2014

A simple, rapid, and highly selective RP-HPLC method was developed for the simultaneous determination of Ambrisentan (AMB) and Tadalafil (TADA) drug substances in the fixed dosage strength of 10 mg and 40 mg, respectively. Effective chromatographic separation was achieved using a Hypersil GOLD C18 column (150 mm × 4.6 mm internal diameter, 5 μm particle size) with a mobile phase composed of methanol, water, and acetonitrile in the ratio of 40:40:20 (by volume). The mobile phase was pumped using a gradient HPLC system at a flow rate of 0.5 mL/min, and quantification of the analytes was based on measuring their peak areas at 260 nm. The retention times for Ambrisentan and Tadalafil were about 2.80 and 7.10 min, respectively. The reliability and analytical performance of the proposed HPLC procedure were statistically validated with respect to system suitability, linearity, ranges, precision, accuracy, specificity, robustness, detection, and quantification limits. Calibration curves were linear in the ranges of 1–20 μg/mL for Ambrisentan and 4–80 μg/mL for Tadalafil with correlation coefficients >0.990. The proposed method proved to be selective and stability-indicating by the resolution of the two analytes from the forced degradation (hydrolysis, oxidation, and photolysis) products. The validated HPLC method was successfully applied to the analysis of AMB and TADA in pharmaceutical dosage form. © Patel and Patel.

Chavda H.,Hemchandracharya North Gujarat University | Patel C.,Hemchandracharya North Gujarat University
Indian Journal of Pharmaceutical Sciences | Year: 2011

This study discusses efforts made to design drug-delivery system based on superporous hydrogel composite for sustained delivery of ranitidine hydrochloride. The characterization studies involve measurement of apparent density, porosity, swelling studies, mechanical strength studies, and scanning electron microscopy. Scanning electron microscopic images clearly showed the formation of interconnected pores, capillary channels, and the cross-linked sodium carboxymethylcellulose molecules around the peripheries of pores. The prepared system floated and delivered the ranitidine hydrochloride for about 17 h. The release profile of ranitidine hydrochloride was studies by changing the retardant polymer in the system. To ascertain the drug release kinetics, the dissolution profiles were fitted to different mathematical models that include zero-order, first-order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas, Weibull, and Hopfenberg models. The in vitro dissolution from system was explained by Korsmeyer-Peppas model. The diffusion exponent values in Korsmeyer-Peppas model range between 0.480.01 and 0.700.01, which appears to indicate an anomalous non-Fickian transport. It is concluded that the proposed mechanically stable floating drug-delivery system based on superporous hydrogel composite containing sodium carboxymethylcellulose as a composite material is promising for stomach specific delivery of ranitidine hydrochloride.

Patel N.,Hemchandracharya North Gujarat University | Patel J.K.,P.A. College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Telmisartan, an angiotensin II receptor antagonist, is used for the treatment of essential hypertension; the drug has fewer side effects compare to Angiotensin converting enzyme inhibitors. Telmisartan has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, High-performance liquid chromatography with ultraviolet and flourimetry detection, liquid chromatography coupled with tandem mass spectrometry, densitometry, immune assay methods and electrochemical methods such as hydrogen wave polarography. The overview includes the most relevant analytical methodologies used in its determination since the origin still today.

Patel A.,Hemchandracharya North Gujarat University
International Journal of Pharma and Bio Sciences | Year: 2013

A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method has been developed and validated for the determination of Nebivolol hydrochloride and S-amlodipine besylate in combined dosage form. The method obeys Beer's Law in concentration range of 15-35 μg/ml for Nebivolol and 7.5-17.5 μg/ml for S-amlodipine. The method was validated for linearity, range, accuracy, precision and specificity as per ICH guidelines. Zero crossing point for Nebivolol hydrochloride and S-amlodipine besylate was 243 nm and 291 nm respectively in methanol. The developed method as successfully used for the quantitative analysis of commercially available dosage form (Nebicard SM).

Sharma S.,Hemchandracharya North Gujarat University | Patel P.,Hemchandracharya North Gujarat University
Fluid Phase Equilibria | Year: 2015

Refractive indexes (ηD), speed of sound (u) have been measured for binary mixtures of N-formylmorpholine+fluorobenzene,+chlorobenzene,+bromobenzene at 303.15, 308.15 and 313.15K and at atmospheric pressure over whole composition range. Deviation in refractive index (δηD), molar refraction (Rm) and deviation in molar refraction (δRm) have been calculated using measured values of refractive indexes. Deviation in speed of sound (δu), deviation in isentropic compressibility (δks) and deviation in acoustic impedance (δz) have been calculated from measured values of speed of sound. Theoretical refractive index values are calculated using nine relations namely Arago-Biot (A-B), Dale-Glastone (D-G), Lorentz-Lorentz (L-L), Weiner (WR), Heller (Hr), Newton (Nw), Eyring-John (E-J) Eykman (Eyk), Oster (Os) and their average deviation with experimental measured values have been calculated. Theoretical speed of sound is also calculated by using relations like Nomoto's relation, Ideal mixture relation, Junjie's relation, Free length theory relation and their average deviation from experimental values of speed of sound have been calculated. The FT-IR spectra's of pure components and their binaries at three different composition (v/v) 1:4, 1:1 and 4:1 have been measured at 298.15K for interpretation of intermolecular interaction between molecules of binary liquid mixtures. The results revealed negative values for deviation in molar refraction (δRm), deviation in isentropic compressibility (δks) and positive value for deviation in refractive index (δnD), deviation in speed of sound (δu) and deviation in acoustic impedance (δz). The results support the idea that strong interactions occur between molecules of binary mixtures. All the computed results were fitted with the Redlich-Kister type polynomial equation. © 2014 Elsevier B.V.

Chothani D.L.,Hemchandracharya North Gujarat University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: The aim of present study was to carry out preliminary phytochemical screening, detailed pharmacognostic profile and physicochemical evaluation of leaf of Gmelina arborea. Methods: Fresh leaf and dried power of the leaves were studied by morphology, microscopy, preliminary phytochemical screening, and florescence analysis of powdered drug. Other physicochemical parameters were also performed as per WHO guide lines. Result: The detailed microscopy revealed that the presence of anomocytic stomata and covering uni-multicellular trichome. Leaf constant such as stomatal number, stomata index, vein islet number, vein termination number were also determined. Physicochemical parameters and florescence analysis were also studied. The preliminary phytochemical screening showed the presence of steroid, triterpenoid, saponin, protein, phenolic compound, flavanoid and carbohydrates. Conclusions: The result of these studies could be useful for correct identification and detection of adulterants of this plant material. © 2012 Asian Pacific Tropical Biomedical Magazine.

Sawant S.Y.,Indian Central Salt and Marine Chemicals Research Institute | Somani R.S.,Indian Central Salt and Marine Chemicals Research Institute | Bajaj H.C.,Indian Central Salt and Marine Chemicals Research Institute | Sharma S.S.,Hemchandracharya North Gujarat University
Journal of Hazardous Materials | Year: 2012

Using metallic copper as reductant and tetrachloroethylene as carbon precursor, a simple, low temperature solvothermal method for the synthesis of horn shaped carbon nanotubes is reported. The detail study of reaction parameters such as temperature, time, carbon precursor amount, type and catalyst proportion has been carried out to optimize the conditions wherein that the copper metal (10g) mediated reduction of tetrachloroethylene (25mL) at 200°C for 5h resulted in the horn shaped carbon nanotubes with high yield and structural selectivity. The adsorption properties of horn shaped carbon nanotubes were investigated for carbon dioxide, methane, carbon monoxide and nitrogen as adsorbate by volumetric measurements up to 850mmHg. The prepared horn shaped carbon nanotubes showed good adsorption capacity for CO 2 (45cm 3/g) and CO (17cm 3/g), at 303K and 850mmHg pressure, with high equilibrium selectivity (73.3 for CO 2 and 110.7 for CO at 318K) and capacity selectivity (9.1 for CO 2 and 3.1 for CO at 850mmHg and 318K) over nitrogen which provides the tool for the separation of CO 2 from its mixture with nitrogen observed in flue gas of thermal power plants and boilers, as well as with CO such as syngas. © 2012 Elsevier B.V..

Mangrola A.V.,Hemchandracharya North Gujarat University | Dudhagara P.,Veer Narmad South Gujarat University | Koringa P.,Anand Agricultural University | Joshi C.G.,Anand Agricultural University | Patel R.K.,Hemchandracharya North Gujarat University
Genomics Data | Year: 2015

This is the first report on the metagenomic approach for unveiling the microbial diversity of Lasundra hot spring, Gujarat State, India. High-throughput sequencing of community DNA was performed on an Ion Torrent PGM platform. Metagenome consisted of 606,867 sequences represent 98,567,305. bps size with an average length of 162. bps and 46% G. +. C content. Metagenome sequence information is available at EBI under EBI Metagenomic database with accession no. ERP009313. MG-RAST assisted community analysis revealed that 99.21% sequences were bacterial origin, 0.43% was fit to eukaryotes and 0.11% belongs to archaea. A total of 29 bacterial, 20 eukaryotic and 4 archaeal phyla were detected. Abundant genera were Bacillus (86.7%), Geobacillus (2.4%), Paenibacillus (1.0%), Clostridium (0.7%) and Listeria (0.5%), that represent 91.52% in metagenome. In functional analysis, Cluster of Orthologous Group (COG) based annotation revealed that 45.4% was metabolism connected and 19.6% falls in poorly characterized group. Subsystem based annotation approach suggests that the 14.0% was carbohydrates, 7.0% was protein metabolism and 3.0% genes for various stress responses together with the versatile presence of commercially useful traits. © 2015 The Authors.

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