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Keshorai Patan, India

Hemchandracharya North Gujarat University is a public university in Patan, Gujarat, India. The geographical jurisdiction of the North Gujarat University encompasses four districts: Mehsana, Patan, Banaskantha and Sabarkantha. It is NACC 'B' accredited state university. Wikipedia.

Chothani D.L.,Hemchandracharya North Gujarat University
Asian Pacific Journal of Tropical Biomedicine

Objective: The aim of present study was to carry out preliminary phytochemical screening, detailed pharmacognostic profile and physicochemical evaluation of leaf of Gmelina arborea. Methods: Fresh leaf and dried power of the leaves were studied by morphology, microscopy, preliminary phytochemical screening, and florescence analysis of powdered drug. Other physicochemical parameters were also performed as per WHO guide lines. Result: The detailed microscopy revealed that the presence of anomocytic stomata and covering uni-multicellular trichome. Leaf constant such as stomatal number, stomata index, vein islet number, vein termination number were also determined. Physicochemical parameters and florescence analysis were also studied. The preliminary phytochemical screening showed the presence of steroid, triterpenoid, saponin, protein, phenolic compound, flavanoid and carbohydrates. Conclusions: The result of these studies could be useful for correct identification and detection of adulterants of this plant material. © 2012 Asian Pacific Tropical Biomedical Magazine. Source

A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method has been developed and validated for the determination of Nebivolol hydrochloride and S-amlodipine besylate in combined dosage form. The method obeys Beer's Law in concentration range of 15-35 μg/ml for Nebivolol and 7.5-17.5 μg/ml for S-amlodipine. The method was validated for linearity, range, accuracy, precision and specificity as per ICH guidelines. Zero crossing point for Nebivolol hydrochloride and S-amlodipine besylate was 243 nm and 291 nm respectively in methanol. The developed method as successfully used for the quantitative analysis of commercially available dosage form (Nebicard SM). Source

Sawant S.Y.,Indian Central Salt and Marine Chemicals Research Institute | Somani R.S.,Indian Central Salt and Marine Chemicals Research Institute | Sharma S.S.,Hemchandracharya North Gujarat University | Bajaj H.C.,Indian Central Salt and Marine Chemicals Research Institute

A simple solid-state dechlorination route has been demonstrated to synthesize few layered functionalized carbon nanosheets (FCNS) utilizing hexachloroethane as carbon source and copper as reducing agent under the autogenic pressure at 300 C. The obtained FCNS possesses the sheet thickness of 6-12 nm as analyzed by transmission electron microscopy. The particle nature of the FCNS provides the excess porosity having the surface area 836 m 2/g. The equilibrium gas adsorption study of FCNS for greenhouse gases (CO2 and CH4), toxic gas (CO) and light gas (N 2) showed the maximum adsorption capacity for CO2 (2.95 mmol/g; at 288 K) with maximum capacity selectivity of 10.1 at 318 K. The very strong adsorbate-adsorbent interaction was observed in case of CO compare to other gases resulted in higher heat of adsorption for CO. The gas adsorption and FT-IR study showed that the interaction of CO with copper present in minute quantities in FCNS improves the CO adsorption due to π complexation. The FCNS obtained under present methodology showed the very high equilibrium selectivity for CO over N2 (197) followed by CH4 (61) and CO 2 (7.3) at 288 K. © 2013 Elsevier Ltd. All rights reserved. Source

Patel D.B.,Hemchandracharya North Gujarat University
International Journal of Pharma and Bio Sciences

The aim of this study was to investigate the effect of different carriers on solubility and in vitro dissolution of poorly water soluble drug meloxicam (MLX). Solid dispersions with Polyethylene glycol-6000 (PEG6000), Poloxamer 188 (Plx188), Poloxamer 407 (Plx407) and inclusion complexes (ICs) with β cyclodextrin (β-CD) were prepared by different methods in three different weight ratios. All SDs and ICs were evaluated for percentage practical yield, drug content, solubility and dissolution studies and characterized by FTIR and powder X-ray diffraction studies. The improvement of solubility using polymers was in the following order: Plx188 > Plx407 > PEG6000 > β-CD. In Dissolution studies, maximum drug release (99.46% at 90 min) were obtained in 1:3 ratios of MLX to Plx188. Solid dispersion of MLX with Plx188 by fusion method in 1:3 ratios can be used to formulate fast dissolving solid dosage form to enhance drug dissolution. Source

Mangrola A.V.,Hemchandracharya North Gujarat University | Dudhagara P.,Veer Narmad South Gujarat University | Koringa P.,Anand Agricultural University | Joshi C.G.,Anand Agricultural University | Patel R.K.,Hemchandracharya North Gujarat University
Genomics Data

This is the first report on the metagenomic approach for unveiling the microbial diversity of Lasundra hot spring, Gujarat State, India. High-throughput sequencing of community DNA was performed on an Ion Torrent PGM platform. Metagenome consisted of 606,867 sequences represent 98,567,305. bps size with an average length of 162. bps and 46% G. +. C content. Metagenome sequence information is available at EBI under EBI Metagenomic database with accession no. ERP009313. MG-RAST assisted community analysis revealed that 99.21% sequences were bacterial origin, 0.43% was fit to eukaryotes and 0.11% belongs to archaea. A total of 29 bacterial, 20 eukaryotic and 4 archaeal phyla were detected. Abundant genera were Bacillus (86.7%), Geobacillus (2.4%), Paenibacillus (1.0%), Clostridium (0.7%) and Listeria (0.5%), that represent 91.52% in metagenome. In functional analysis, Cluster of Orthologous Group (COG) based annotation revealed that 45.4% was metabolism connected and 19.6% falls in poorly characterized group. Subsystem based annotation approach suggests that the 14.0% was carbohydrates, 7.0% was protein metabolism and 3.0% genes for various stress responses together with the versatile presence of commercially useful traits. © 2015 The Authors. Source

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