Hemchandracharya North Gujarat University

www.ngu.ac.in
Keshorai Patan, India

Hemchandracharya North Gujarat University is a public university in Patan, Gujarat, India. The geographical jurisdiction of the North Gujarat University encompasses four districts: Mehsana, Patan, Banaskantha and Sabarkantha. It is NACC 'B' accredited state university. Wikipedia.


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Patel A.,Hemchandracharya North Gujarat University
International Journal of Pharma and Bio Sciences | Year: 2013

A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method has been developed and validated for the determination of Nebivolol hydrochloride and S-amlodipine besylate in combined dosage form. The method obeys Beer's Law in concentration range of 15-35 μg/ml for Nebivolol and 7.5-17.5 μg/ml for S-amlodipine. The method was validated for linearity, range, accuracy, precision and specificity as per ICH guidelines. Zero crossing point for Nebivolol hydrochloride and S-amlodipine besylate was 243 nm and 291 nm respectively in methanol. The developed method as successfully used for the quantitative analysis of commercially available dosage form (Nebicard SM).


Sharma S.,Hemchandracharya North Gujarat University | Patel P.,Hemchandracharya North Gujarat University
Fluid Phase Equilibria | Year: 2015

Refractive indexes (ηD), speed of sound (u) have been measured for binary mixtures of N-formylmorpholine+fluorobenzene,+chlorobenzene,+bromobenzene at 303.15, 308.15 and 313.15K and at atmospheric pressure over whole composition range. Deviation in refractive index (δηD), molar refraction (Rm) and deviation in molar refraction (δRm) have been calculated using measured values of refractive indexes. Deviation in speed of sound (δu), deviation in isentropic compressibility (δks) and deviation in acoustic impedance (δz) have been calculated from measured values of speed of sound. Theoretical refractive index values are calculated using nine relations namely Arago-Biot (A-B), Dale-Glastone (D-G), Lorentz-Lorentz (L-L), Weiner (WR), Heller (Hr), Newton (Nw), Eyring-John (E-J) Eykman (Eyk), Oster (Os) and their average deviation with experimental measured values have been calculated. Theoretical speed of sound is also calculated by using relations like Nomoto's relation, Ideal mixture relation, Junjie's relation, Free length theory relation and their average deviation from experimental values of speed of sound have been calculated. The FT-IR spectra's of pure components and their binaries at three different composition (v/v) 1:4, 1:1 and 4:1 have been measured at 298.15K for interpretation of intermolecular interaction between molecules of binary liquid mixtures. The results revealed negative values for deviation in molar refraction (δRm), deviation in isentropic compressibility (δks) and positive value for deviation in refractive index (δnD), deviation in speed of sound (δu) and deviation in acoustic impedance (δz). The results support the idea that strong interactions occur between molecules of binary mixtures. All the computed results were fitted with the Redlich-Kister type polynomial equation. © 2014 Elsevier B.V.


Prajapati S.N.,Hemchandracharya North Gujarat University | Parmar K.A.,Hemchandracharya North Gujarat University
International Journal of Phytomedicine | Year: 2011

The aim of this research was to develop the pharmacognostical parameters and phytochemical screening along with histological studies and the leaf powder of Rubia cordifolia. The dried leaves of Rubia cordifolia. (Family: Rubiaceae) were subjected to standardization by following pharmacognostical and phytochemical screening methods. Rubia cordifolia was investigated for preliminary phytochemical analysis and characterization by various instrumental techniques. Methanolic extracts of Rubia cordifolia leaves was very good antibacterial activity and also minimum inhibitory concentrating of different virus using HEL cell cultures, HeLa cell cultures and Vero cell cultures but MIC of Herpes simplex - 1 and 2, vaccinia virus, vesicular stomatitis and Herpes simplex-1 (TK ACVI) were observed very good antiviral activity of Rubia cordifolia leaves DMSO extracts has good minimum cytotoxic concentration activity and also screening for various pharmaceuticals activities. Such as anti oxidant and microbial activities.


Chothani D.L.,Hemchandracharya North Gujarat University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: The aim of present study was to carry out preliminary phytochemical screening, detailed pharmacognostic profile and physicochemical evaluation of leaf of Gmelina arborea. Methods: Fresh leaf and dried power of the leaves were studied by morphology, microscopy, preliminary phytochemical screening, and florescence analysis of powdered drug. Other physicochemical parameters were also performed as per WHO guide lines. Result: The detailed microscopy revealed that the presence of anomocytic stomata and covering uni-multicellular trichome. Leaf constant such as stomatal number, stomata index, vein islet number, vein termination number were also determined. Physicochemical parameters and florescence analysis were also studied. The preliminary phytochemical screening showed the presence of steroid, triterpenoid, saponin, protein, phenolic compound, flavanoid and carbohydrates. Conclusions: The result of these studies could be useful for correct identification and detection of adulterants of this plant material. © 2012 Asian Pacific Tropical Biomedical Magazine.


Sawant S.Y.,Indian Central Salt and Marine Chemicals Research Institute | Somani R.S.,Indian Central Salt and Marine Chemicals Research Institute | Sharma S.S.,Hemchandracharya North Gujarat University | Bajaj H.C.,Indian Central Salt and Marine Chemicals Research Institute
Carbon | Year: 2014

A simple solid-state dechlorination route has been demonstrated to synthesize few layered functionalized carbon nanosheets (FCNS) utilizing hexachloroethane as carbon source and copper as reducing agent under the autogenic pressure at 300 C. The obtained FCNS possesses the sheet thickness of 6-12 nm as analyzed by transmission electron microscopy. The particle nature of the FCNS provides the excess porosity having the surface area 836 m 2/g. The equilibrium gas adsorption study of FCNS for greenhouse gases (CO2 and CH4), toxic gas (CO) and light gas (N 2) showed the maximum adsorption capacity for CO2 (2.95 mmol/g; at 288 K) with maximum capacity selectivity of 10.1 at 318 K. The very strong adsorbate-adsorbent interaction was observed in case of CO compare to other gases resulted in higher heat of adsorption for CO. The gas adsorption and FT-IR study showed that the interaction of CO with copper present in minute quantities in FCNS improves the CO adsorption due to π complexation. The FCNS obtained under present methodology showed the very high equilibrium selectivity for CO over N2 (197) followed by CH4 (61) and CO 2 (7.3) at 288 K. © 2013 Elsevier Ltd. All rights reserved.


Sawant S.Y.,Indian Central Salt and Marine Chemicals Research Institute | Somani R.S.,Indian Central Salt and Marine Chemicals Research Institute | Bajaj H.C.,Indian Central Salt and Marine Chemicals Research Institute | Sharma S.S.,Hemchandracharya North Gujarat University
Journal of Hazardous Materials | Year: 2012

Using metallic copper as reductant and tetrachloroethylene as carbon precursor, a simple, low temperature solvothermal method for the synthesis of horn shaped carbon nanotubes is reported. The detail study of reaction parameters such as temperature, time, carbon precursor amount, type and catalyst proportion has been carried out to optimize the conditions wherein that the copper metal (10g) mediated reduction of tetrachloroethylene (25mL) at 200°C for 5h resulted in the horn shaped carbon nanotubes with high yield and structural selectivity. The adsorption properties of horn shaped carbon nanotubes were investigated for carbon dioxide, methane, carbon monoxide and nitrogen as adsorbate by volumetric measurements up to 850mmHg. The prepared horn shaped carbon nanotubes showed good adsorption capacity for CO 2 (45cm 3/g) and CO (17cm 3/g), at 303K and 850mmHg pressure, with high equilibrium selectivity (73.3 for CO 2 and 110.7 for CO at 318K) and capacity selectivity (9.1 for CO 2 and 3.1 for CO at 850mmHg and 318K) over nitrogen which provides the tool for the separation of CO 2 from its mixture with nitrogen observed in flue gas of thermal power plants and boilers, as well as with CO such as syngas. © 2012 Elsevier B.V..


Ghelani A.,Shree Ramkrishna Institute of Computer Education and Applied science | Ghelani A.,Hemchandracharya North Gujarat University | Patel R.,Hemchandracharya North Gujarat University | Mangrola A.,Hemchandracharya North Gujarat University | Dudhagara P.,Veer Narmad South Gujarat University
Genomics Data | Year: 2015

A taxonomic description of bacteria was deduced from 5.78. Mb metagenomic sequence retrieved from Tulsi Shyam hot spring, India using bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP). Metagenome contained 10,893 16S rDNA sequences that were analyzed by MG-RAST server to generate the comprehensive profile of bacteria. Metagenomic data are available at EBI under EBI Metagenomics database with accession no. ERP009559. Metagenome sequences represented the 98.2% bacteria origin, 1.5% of eukaryotic and 0.3% were unidentified. A total of 16 bacterial phyla demonstrating 97 families and 287 species were revealed in the hot spring metagenome. Most abundant phyla were Firmicutes (65.38%), Proteobacteria (21.21%) and unclassified bacteria (10.69%). Whereas, Peptostreptococcaceae (37.33%), Clostridiaceae (23.36%), and Enterobacteriaceae (16.37%) were highest reported families in metagenome. Ubiquitous species were Clostridium bifermentans (17.47%), Clostridium lituseburense (13.93%) and uncultured bacterium (10.15%). Our data provide new information on hot spring bacteria and shed light on their abundance, diversity, distribution and coexisting organisms. © 2015 The Authors.


Dudhagara P.,Veer Narmad South Gujarat University | Ghelani A.,Shree Ramkrishna Institute of Computer Education and Applied science | Patel R.,Hemchandracharya North Gujarat University | Chaudhari R.,Hemchandracharya North Gujarat University | Bhatt S.,Hemchandracharya North Gujarat University
Genomics Data | Year: 2015

Bacterial diversity and archaeal diversity in metagenome of the Lonar soda lake sediment were assessed by bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP). Metagenome comprised 5093 sequences with 2,531,282. bp and 53 ± 2% G. +. C content. Metagenome sequence data are available at NCBI under the Bioproject database with accession no. PRJNA218849. Metagenome sequence represented the presence of 83.1% bacterial and 10.5% archaeal origin. A total of 14 different bacteria demonstrating 57 species were recorded with dominating species like Coxiella burnetii (17%), Fibrobacter intestinalis (12%) and Candidatus Cloacamonas acidaminovorans (11%). Occurrence of two archaeal phyla representing 24 species, among them Methanosaeta harundinacea (35%), Methanoculleus chikugoensis (12%) and Methanolinea tarda (11%) were dominating species. Significant presence of 11% sequences as an unclassified indicated the possibilities for unknown novel prokaryotes from the metagenome. © 2015 The Authors.


Mangrola A.V.,Hemchandracharya North Gujarat University | Dudhagara P.,Veer Narmad South Gujarat University | Koringa P.,Anand Agricultural University | Joshi C.G.,Anand Agricultural University | Patel R.K.,Hemchandracharya North Gujarat University
Genomics Data | Year: 2015

This is the first report on the metagenomic approach for unveiling the microbial diversity of Lasundra hot spring, Gujarat State, India. High-throughput sequencing of community DNA was performed on an Ion Torrent PGM platform. Metagenome consisted of 606,867 sequences represent 98,567,305. bps size with an average length of 162. bps and 46% G. +. C content. Metagenome sequence information is available at EBI under EBI Metagenomic database with accession no. ERP009313. MG-RAST assisted community analysis revealed that 99.21% sequences were bacterial origin, 0.43% was fit to eukaryotes and 0.11% belongs to archaea. A total of 29 bacterial, 20 eukaryotic and 4 archaeal phyla were detected. Abundant genera were Bacillus (86.7%), Geobacillus (2.4%), Paenibacillus (1.0%), Clostridium (0.7%) and Listeria (0.5%), that represent 91.52% in metagenome. In functional analysis, Cluster of Orthologous Group (COG) based annotation revealed that 45.4% was metabolism connected and 19.6% falls in poorly characterized group. Subsystem based annotation approach suggests that the 14.0% was carbohydrates, 7.0% was protein metabolism and 3.0% genes for various stress responses together with the versatile presence of commercially useful traits. © 2015 The Authors.


Patel D.B.,Hemchandracharya North Gujarat University
International Journal of Pharma and Bio Sciences | Year: 2014

The aim of this study was to investigate the effect of different carriers on solubility and in vitro dissolution of poorly water soluble drug meloxicam (MLX). Solid dispersions with Polyethylene glycol-6000 (PEG6000), Poloxamer 188 (Plx188), Poloxamer 407 (Plx407) and inclusion complexes (ICs) with β cyclodextrin (β-CD) were prepared by different methods in three different weight ratios. All SDs and ICs were evaluated for percentage practical yield, drug content, solubility and dissolution studies and characterized by FTIR and powder X-ray diffraction studies. The improvement of solubility using polymers was in the following order: Plx188 > Plx407 > PEG6000 > β-CD. In Dissolution studies, maximum drug release (99.46% at 90 min) were obtained in 1:3 ratios of MLX to Plx188. Solid dispersion of MLX with Plx188 by fusion method in 1:3 ratios can be used to formulate fast dissolving solid dosage form to enhance drug dissolution.

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