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Chandigarh, India

Tadmor T.,Hematology Oncology Unit
Leukemia and Lymphoma

The introduction of cladribine and pentostatin for the treatment of hairy cell leukemia (HCL) has dramatically altered the natural history of the disease, and a single course of cladribine given as a subcutaneous injection for 7 days induces complete remission in the majority of patients. A systematic evaluation of the immediate and long-term side effects induced by purine analogs reveals that most of the available information relates to fludarabine, and mostly refers to the use of this agent in the treatment of indolent lymphoproliferative disorders (LPDs) and and chronic lymphocytic leukemia (CLL). Surprisingly, although purine analogs have been used for more than 30 years in the treatment of HCL, there are still not many reports on the toxicity of pentostatin and cladribine other than the early therapy-induced toxicity encountered in the initial management of patients. Only a few studies have evaluated the long-term adverse effects of purine analogs on the immune system or stem cell toxicity, and most of these are not very recent. In addition, the issue of the prevalence of secondary malignancy linked with the therapy of HCL still remains controversial. In this review the available data on cladribine and pentostatin toxicity in the treatment of HCL are summarized, emphasizing immune suppression, stem cell toxicity, and possible correlation with the development of second malignancy. Other rare toxicities are also described, and the special conditions that need to be taken into account when starting treatment for patients with HCL are also considered. © 2011 Informa UK, Ltd. Source

Ben-Arye E.,Oncology Service and Lin Medical Center | Ben-Arye E.,Technion - Israel Institute of Technology | Attias S.,Haifa University | Tadmor T.,Hematology Oncology Unit | And 2 more authors.
Leukemia and Lymphoma

Herbal remedies are clearly a complementary and alternative modality used frequently by patients with hemato-oncological neoplasias during the course of their specific treatment. This review focuses on the potential safety and efficacy of herbs which are either used often or even on a daily basis by patients with hematological malignancies or indicated in the herbal pharmacopeias utilized by various traditional systems of medicine, in order to improve the well-being of patients with these cancers. Traditional medicine worldwide is a source for ongoing laboratory research related to the activity of herbs on cultured cell lines derived from patients with leukemia, lymphoma, and myeloma. Although the number of clinical studies in the field of hemato-oncology is limited, there appears to be potential efficacy in studies of mistletoe (Viscum album), green tea, Indian and Middle-Eastern spices, and some traditional Chinese, American, and European herbs. In addition to the potential efficacy of herbs, safety issues are also reviewed here, particularly, the documented and potential side effects, herbdrug interactions, and matters of quality control. Based on the above issues, the authors suggest enhancing doctorpatient communication regarding herbal use by adopting a patient-centered attitude based on scientific perspective. © 2010 Informa UK, Ltd. Source

Cecinati V.,Santo Spirito Hospital | Principi N.,University of Milan | Brescia L.,Hematology Oncology Unit | Esposito S.,University of Milan
European Journal of Clinical Microbiology and Infectious Diseases

Bacterial infections are common in children with cancer and can lead to life-threatening complications. Infections in these patients mainly occur during neutropenic periods, and may be caused by Gram-positive or Gram-negative bacteria. The patients at highest risk of serious infections include those with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), and those undergoing myeloablative hematopoietic cell transplantation (HCT). This is a review with the main aim of making a critical appraisal of the literature, and summarising what is currently known and can be recommended. The most significant studies support the use of floroquinolones (mainly ciprofloxacin) as the most rational approach to treat pediatric patients with probably long-lasting neutropenia, although trimetoprim-sulphametoxazole and amoxicillin/clavulanate may theoretically be valid alternatives. No prophylaxis seems to be needed for children with cancer without severe neutropenia. However, a global evaluation of the studies of antibiotic prophylaxis in children with cancer indicates that there are not enough data to prepare definite guidelines for its use or avoidance in pediatric oncology, and so further studies are needed. It is not only important to define the best antibiotic regimens for the children in whom such prophylaxis is useful, but also to identify precisely those who do not need it. This would avoid the antibiotic misuse that probably occurs at the moment because many low-risk children with cancer are treated. As prophylaxis against infections requires long-term adherence to an antibiotic regimen, the attitudes and beliefs of stakeholders need to be fully considered. © 2013 Springer-Verlag Berlin Heidelberg. Source

Deutsch Y.E.,University of Miami | Tadmor T.,Hematology Oncology Unit | Podack E.R.,University of Miami | Rosenblatt J.D.,University of Miami
Leukemia and Lymphoma

CD30 is abundantly and selectively expressed on the surface of Hodgkin ReedSternberg cells, anaplastic large cell lymphomas (ALCLs), and other lymphoid malignancies as well as on several non-lymphoid malignancies including selected germ cell tumors. Expression of CD30 on normal cells is highly restricted, thereby allowing differential targeting of malignant cells. CD30, a member of the tumor necrosis factor (TNF)-receptor family has pleiotropic biologic functions, and antibodies targeting CD30 and other TNF family receptors can exhibit both agonistic and antagonistic signaling functions. Recently, antibodydrug conjugates targeting CD30, such as brentuximab vedotin, have shown striking activity in phase I and II trials, with manageable toxicity. This has defined an important emerging role for targeting of CD30 in the setting of Hodgkin lymphoma, ALCL, and possibly other CD30+ malignancies. © 2011 Informa UK, Ltd. Source

Ben-Arye E.,Rothschild | Ben-Arye E.,Technion - Israel Institute of Technology | Polliack A.,Hebrew University of Jerusalem | Schiff E.,Bnai Zion Medical Center | And 3 more authors.
Journal of Pain and Symptom Management

Context: Many cancer patients are using non-herbal nutritional supplements (NHNS), often without informing their oncologists. Objectives: To review the literature and summarize the beneficial effects and safety of NHNS in the prevention and reduction of treatment-related symptoms. Methods: Databases were searched for randomized, controlled clinical trials (Jadad score ≥ 2) using AltHealthWatch, Cochrane Database of Systematic Reviews, Embase, MEDLINE, Memorial Sloan-Kettering Integrative Medicine Service Database, Natural Standard Database, and PubMed. The key words searched were the following: alternative and/or complementary medicine, nutritional and/or dietary supplements, quality of life, symptoms and/or side effects, specific toxicities (e.g., neuropathy, mucositis), and specific supplements (e.g., vitamin E, glutamine, etc.). Results: A number of NHNS products were found to be effective. The incidence and severity of peripheral sensory neuropathy associated with taxane-agents such as paclitaxel can be reduced with vitamin E, glutamine, and acetyl-L-carnitine. Vitamin E and glutamine also have been shown to reduce oral mucositis resulting from radiation and chemotherapy, and glutamine and probiotics can reduce chemotherapy-induced diarrhea. Conclusion: There is a need to develop an open and nonjudgmental dialogue between oncologists and cancer patients, addressing the needs of the patient while dealing with issues related to the efficacy and safety of these products. Referral of patients to an integrative medicine consultant may help achieve these goals, providing both parties with the option of reaching an informed and respectful decision about treatment. © 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved. Source

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