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Rahmani A.,Hematology and Oncology Research Center | Ferguson C.,University of Technology, Sydney | Mohammadpoorasl A.,Qazvin University of Medical Sciences | Pakpour V.,Tabriz University of Medical Sciences
Indian Journal of Palliative Care | Year: 2014

Background: A supportive needs assessment is an essential component of any care program. There is no research evidence regarding the supportive care needs of cancer patients in Iran or other Middle Eastern countries. Aims: The aim of this study was to determine the supportive care needs of Iranian cancer patients. Materials and Methods: This descriptive study was conducted in a referral medical center in the northwest of Iran. A total of 274 cancer patients completed the Supportive Care Needs Survey (SCNS-59). Descriptive statistics were used for data analysis. Results: In 18 items of the SCNS, more than 50% of the participants reported that their needs were unmet. Most frequently, unmet needs were related to the health system, information, physical, and daily living domains, and most met needs were related to sexuality, patient care, and support domains. Conclusions: Iranian cancer patients experience many unmet needs and there is an urgent need for establishing additional supportive care services in Iran. © 2014 Indian Journal of Palliative Care.

Imani S.,Baqiyatallah Medical Sciences University | Zand A.M.,I.H.U. | Borna H.,Baqiyatallah Medical Sciences University | Panahi Y.,Baqiyatallah Medical Sciences University | And 6 more authors.
European Journal of Oncology | Year: 2014

Aim of study: Blood cancers (BCs) are diseases that are hard to handle and can easily cause death. The statistics show that about 245,000 people have some form of BC. There are many factors affecting BC where preventing BC entails controlling these factors. The purpose of this retrospective study is to find which genetic and environmental risk factors in cancer have led to increased leukaemia over time. Materials and Methods: 762 patients with various BCs in haematology and oncology A and B sections of Shari’ati Hospital, who met the inclusion criteria, were enrolled in this retrospectively study from 2009- 2011. Patients’ information was collected using a researcher-made questionnaire from the moment patients arrived. Age, gender, ABO and Rh blood group, patient’s occupation, climate type (where patients live), Systolic and Diastolic Blood Pressure (SBP & DBP), Platelet (Plt) and hemoglobin (Hb) Count were carefully analyzed. Information questionnaires were processed in open source R software. Frequency and probability table, classification tree, correlations, χ2 and logistic regression, regression models were calculated so as to achieve a wide and clear perspective of impacting factors. A regression model was prepared and studied for possible influences. This study considered all probability less than 0.05 significant. Some factors were normalized or adjusted for data missing from questionnaires. Results: Results showed that the disease in men was 1.5 times higher than in women. Blood types (43%) along with positive Rh (76%) have the highest risk of BC. Low platelet count correlates more than 80% with BC. Patients who work in administration (32.7%) and services (28.7%) are more susceptible to leukaemia and most of the leukaemia patients were from warm dry regions (50.0%). The role of fatness in BC emergence is statistically ignorable. BC cases increase during the second decade of human life (48.7%), a fact which might be attributed to maturation processes. Conclusions: By due consideration of these environmental factors, we can make a proper evaluation of leukaemia and its prevention. © 2014, Mattioli 1885 S.p.A. All rights Reserved.

Seifi S.,Hematology and Oncology Research Center | Asvadi Kermani I.,Hematology and Oncology Research Center | Dolatkhah R.,Tabriz University of Medical Sciences
Journal of Clinical and Diagnostic Research | Year: 2010

Acute Myeloid Leukemia accounts about 80% of adult acute leukemias, that presents as de novo or following MDS. It shows typical clinical and cytological pattern of presentation, Hepatosplenomegaly presents in one third of the cases and Lymphadenopathy, extramedullary involvement are rarely seen. We tried to report an uncommon occurrence of AML in a 21 y/o female who admitted in Rheumatology service as a spondylitis. She experienced low back pain, anorexia, sever weight loss, fever, tenderness of lumbar spines and head of left humorous accumpanied with limited left shoulder girdle movements, and hematocytologic and pathologic challenges were not clear enough for specific diagnosis. The clinical and paraclinical findings of the case looked uncommon for de novo leukemia or MDS-AML. Even thought there were so many questions left without clear answer but the diagnosis of Acute Myeloid Leukemia confirmed histopathologically.

Safaee R.,Hematology and Oncology Research Center | Ahmadzadeh A.,Hematology and Oncology Research Center | Sharifian R.,Hematology and Oncology Research Center | Emami A.,Hematology and Oncology Research Center | And 3 more authors.
Hematology Reports | Year: 2012

The aim of this study was to design a regimen for refractory multiple myeloma with minimum complications to achieve a reasonable response. Fifteen patients with active multiple myeloma after at least two lines of conventional treatment underwent therapy with our regimen for two cycles. Disease activity was evaluated after the last cycle. Another 15 patients with refractory multiple myelomas that had previously received only supportive therapy and pain management formed a historical control group. The followup period was 12 months for each study group. Of the patients receiving therapy, 6.7% achieved a complete response and 26.7% a partial response; overall response rate was 33.3%. Stable disease was achieved in 46.7% and 20% of the patients had progressive disease. There was no treatment related mortality. The hazard rate of death was 0.73 lower in the intervention group than in the historical control group. In the historical control group, 60% had progressive disease and 40% had stable disease; approximately 40% of patients died during the 12month follow up. Also, the severity of pain was significantly reduced in the intervention group (P=0.033). Our chemotherapy regimen showed a reasonable response in end stage patients with multiple myeloma in terms of disease control, reducing bone pain and improving survival, in addition to reducing toxicity. © 2012 R. Safaee et al.

Dolatkhah R.,Liver and Gastrointestinal Disease Research Center | Khoshbaten M.,Liver and Gastrointestinal Disease Research Center | Asvadi Kermani I.,Liver and Gastrointestinal Disease Research Center | Reza Bonyadi M.,Drug Applied Research Center | And 4 more authors.
European Journal of Gastroenterology and Hepatology | Year: 2011

OBJECTIVE: Upper gastrointestinal (UGI) bleeding is one of the most life-threatening complications, in up to 25% of persons with hemophilia (PWH). Recurrent bleeding is common and can be caused by the Helicobacter pylori infection. Our aim was to evaluate the role of H. pylori infection in UGI bleeding in PWH. MATERIAL AND METHODS: Ninety patients with hereditary bleeding disorders, 30 patients with (group A), and 60 patients without (group B) a history of UGI bleeding episodes were included. The prevalence of H. pylori infection was investigated by stool antigen test, and serum serologic tests including immunoglobulin G and anti-CagA. RESULTS: Among 90 patients (81 men, nine women, mean age 31.30±10.72 years), 66 patients with hemophilia A, 10 patients with hemophilia B, six patients with Von Willebrand disease, five patients with platelet function disorders, and three patients with other factor deficiencies were evaluated. About 46.7% of patients in group A, and 23.3% of patients in group B were anti-CagA-positive (P=0.02), whereas 76.7% of patients in group A and 51.7% of patients in group B had H. pylori immunoglobulin G antibodies (P=0.02). H. pylori antigen in stool was positive in 76.7% in group A and 55% in group B (P=0.03). No statistically significant difference was found between type and severity of diseases and risk of UGI. CONCLUSION: H. pylori infection should be considered as an important cause of UGI bleeding in PWH. We would recommend stool antigen test as a new and noninvasive screening test for diagnosis of H. pylori infection in all patients with hereditary hemorrhagic disorders. © 2011 Wolters Kluwer Health | Lippincott Williams &Wilkins.

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