Hematology and Oncology Research Center

Hematology and Oncology Research Center

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Rahmani A.,Hematology and Oncology Research Center | Ferguson C.,University of Technology, Sydney | Mohammadpoorasl A.,Qazvin University of Medical Sciences | Pakpour V.,Tabriz University of Medical Sciences
Indian Journal of Palliative Care | Year: 2014

Background: A supportive needs assessment is an essential component of any care program. There is no research evidence regarding the supportive care needs of cancer patients in Iran or other Middle Eastern countries. Aims: The aim of this study was to determine the supportive care needs of Iranian cancer patients. Materials and Methods: This descriptive study was conducted in a referral medical center in the northwest of Iran. A total of 274 cancer patients completed the Supportive Care Needs Survey (SCNS-59). Descriptive statistics were used for data analysis. Results: In 18 items of the SCNS, more than 50% of the participants reported that their needs were unmet. Most frequently, unmet needs were related to the health system, information, physical, and daily living domains, and most met needs were related to sexuality, patient care, and support domains. Conclusions: Iranian cancer patients experience many unmet needs and there is an urgent need for establishing additional supportive care services in Iran. © 2014 Indian Journal of Palliative Care.

Dolatkhah R.,Liver and Gastrointestinal Disease Research Center | Khoshbaten M.,Liver and Gastrointestinal Disease Research Center | Asvadi Kermani I.,Liver and Gastrointestinal Disease Research Center | Reza Bonyadi M.,Drug Applied Research Center | And 4 more authors.
European Journal of Gastroenterology and Hepatology | Year: 2011

OBJECTIVE: Upper gastrointestinal (UGI) bleeding is one of the most life-threatening complications, in up to 25% of persons with hemophilia (PWH). Recurrent bleeding is common and can be caused by the Helicobacter pylori infection. Our aim was to evaluate the role of H. pylori infection in UGI bleeding in PWH. MATERIAL AND METHODS: Ninety patients with hereditary bleeding disorders, 30 patients with (group A), and 60 patients without (group B) a history of UGI bleeding episodes were included. The prevalence of H. pylori infection was investigated by stool antigen test, and serum serologic tests including immunoglobulin G and anti-CagA. RESULTS: Among 90 patients (81 men, nine women, mean age 31.30±10.72 years), 66 patients with hemophilia A, 10 patients with hemophilia B, six patients with Von Willebrand disease, five patients with platelet function disorders, and three patients with other factor deficiencies were evaluated. About 46.7% of patients in group A, and 23.3% of patients in group B were anti-CagA-positive (P=0.02), whereas 76.7% of patients in group A and 51.7% of patients in group B had H. pylori immunoglobulin G antibodies (P=0.02). H. pylori antigen in stool was positive in 76.7% in group A and 55% in group B (P=0.03). No statistically significant difference was found between type and severity of diseases and risk of UGI. CONCLUSION: H. pylori infection should be considered as an important cause of UGI bleeding in PWH. We would recommend stool antigen test as a new and noninvasive screening test for diagnosis of H. pylori infection in all patients with hereditary hemorrhagic disorders. © 2011 Wolters Kluwer Health | Lippincott Williams &Wilkins.

Seifi S.,Hematology and Oncology Research Center | Asvadi Kermani I.,Hematology and Oncology Research Center | Dolatkhah R.,Tabriz University of Medical Sciences
Journal of Clinical and Diagnostic Research | Year: 2010

Acute Myeloid Leukemia accounts about 80% of adult acute leukemias, that presents as de novo or following MDS. It shows typical clinical and cytological pattern of presentation, Hepatosplenomegaly presents in one third of the cases and Lymphadenopathy, extramedullary involvement are rarely seen. We tried to report an uncommon occurrence of AML in a 21 y/o female who admitted in Rheumatology service as a spondylitis. She experienced low back pain, anorexia, sever weight loss, fever, tenderness of lumbar spines and head of left humorous accumpanied with limited left shoulder girdle movements, and hematocytologic and pathologic challenges were not clear enough for specific diagnosis. The clinical and paraclinical findings of the case looked uncommon for de novo leukemia or MDS-AML. Even thought there were so many questions left without clear answer but the diagnosis of Acute Myeloid Leukemia confirmed histopathologically.

PubMed | Hematology and Oncology Research Center
Type: Journal Article | Journal: Leukemia & lymphoma | Year: 2014

Cancer-related malnutrition causes morbidity and reduced survival. The aim of this study was to evaluate the nutritional and inflammatory status of patients with acute leukemia in association with duration of neutropenic fever (DNF) and length of hospital stay (LHS) during induction chemotherapy. Fifty-five patients with acute lymphoblastic leukemia (ALL) (n = 28) and acute myeloid leukemia (AML) (n = 27) completed the study. There were significant differences between the two groups according to LHS and DNF (p = 0.022 and p = 0.012, respectively): both had a longer period in patients with AML. The patients were statistically different according to body mass index (BMI), pre-albumin, high-sensitivity C-reactive protein (hs-CRP) and patient-generated subjective global assessment (PG-SGA) score (p = 0.049, p = 0.028, p < 0.001, p = 0.030). In patients with ALL, serum albumin and pre-albumin levels were associated with LHS and DNF, respectively. Moreover, PG-SGA score was associated with DNF. In patients with AML, BMI and second pre-albumin level < 10 mg/dL were associated with DNF. Pre-albumin was the common indicator for chemotherapy-related complications in patients with both ALL and AML. Early nutritional assessment can help to find patients with acute leukemia who need nutritional support, and it may contribute to better outcome and less toxicity.

PubMed | Hematology and Oncology Research Center
Type: Journal Article | Journal: Asian Pacific journal of cancer prevention : APJCP | Year: 2014

The istone deacetylase (HDAC) inhibitor trichostatin A (TSA) is known to mediate the regulation of gene expression and anti proliferation activity in cancer cells. Kruppel-like factor 4 (klf4) is a zinc finger- containing transcription factor of the SP/KLF family, that is expressed in a variety of tissues and regulates cell proliferation, differentiation, tumorigenesis, and apoptosis. It may either either function as a tumor suppressor or an oncogene depending on genetic context of tumors.In this study, we tested the possibility that TSA may increase klf4 expression and cancer cell growth inhibition and apoptosis in SKOV-3 and A549 cells.The cytotoxicity of TSA was determined using the MTT assay test, while klf4 gene expression was assessed by real time PCR and to ability of TSA to induce apoptosis using a Vybrant Apoptosis Assay kit.Our results showed that TSA exerted dose and time dependent cytotoxicity effect on SKOV-3 and A549 cells. Moreover TSA up-regulated klf4 expression. Flow cytometric analysis demonstrated that apoptosis was increased after TSA treatment.Taken together, this study showed that TSA increased klf4 expression in SKOV3 and A549 cell lines, consequently, klf4 may played a tumor-suppressor role by increasing both cell growth inhibition and apoptosis. This study sheds light on the details of molecular mechanisms of HDACI-induced cell cycle arrest and apoptosis.

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