Fozza C.,University of Sassari |
Longu F.,University of Sassari |
Contini S.,University of Sassari |
Galleu A.,University of Sassari |
And 5 more authors.
Regulatory T cells (Treg) have often been ascribed a role in the pathophysiology of several neoplastic diseases considering their potential ability to suppress anti-tumor immunity. This is particularly the case in myelodysplastic syndromes (MDS), which are clonal hematologic disorders characterized by marked immune dysregulation. We analyzed Treg frequencies in a cohort of 36 patients with early-stage MDS using a flow-cytometric approach based on the concomitant expression of CD25 and CD127. MDS patients showed a higher frequency of CD4?high?low Treg than healthy controls (1.51 vs. 1.14%), with no specific effect of patient-and disease-related factors. Our data point to impaired anti-tumor immunity in patients with MDS, even in the early stage, which has already been noted in other clonal disorders. © 2012 S. Karger AG, Basel. Source