Helwan University is a public university based in Helwan, Egypt, which is part of Greater Cairo. It comprises 20 faculties as well as 50 research centers.It is generally known for its engineering and business study courses. Especially notable are its Faculties of Engineering ; the Faculty of Commerce and Business Administration, with specialized departments dealing with foreign trade, international relations, and business information systems; the Faculty of Computers & Information; and the Faculty of Science. Helwan University has no Faculty of Medicine but it does have a Faculty of Nursing, and its Faculty of Pharmacy is known to be the first clinical pharmacy in Egypt. Wikipedia.
Abdel Moneim A.E.,Helwan University
CNS and Neurological Disorders - Drug Targets | Year: 2013
Purslane (Portulaca oleraceae L.), a member of the Portulacaceae family, is widespread as a weed and has been ranked as the eighth most common plant in the world. In order to evaluate purslane herbal aqueous juice as a neuroprotective agent, the antioxidant activity of purslane juice was assessed in vitro and the neuroprotective effects of purslane (1.5 mL/Kg bwt) on rotenone (12 mg/Kg bwt for 12 days) induced biochemical changes and apoptosis in striatum of rats were also examined. The repeated administration of rotenone produced dramatic increases in intercellular content of calcium, dopamine metabolites and apoptosis in the striatum. In addition, rotenone administration caused significant decrease in complex I activity. These biochemical changes and apoptosis inductions were effectively counteracted by administration of purslane. Overall, the present study demonstrated the neuroprotective role of purslane in the striatum and proposes its prophylactic potential against developing brain damage and Parkinson's disease induction followed by rotenone administration, and that purslane may be considered as a potential neuroprotective agent against environmental factors affecting the function of the dopaminergic system. © 2013 Bentham Science Publishers.
Bauomy A.A.,Helwan University
CNS and Neurological Disorders - Drug Targets | Year: 2014
Schistosomiasis is a neglected tropical disease which is associated with neuropsychiatric and neuropathological disorders. Herein, the main goal of the presented work is to investigate the effect of Morus alba leaves extract in mice brain infected with Schistosoma mansoni. Since, the resistance of Schistosomes to antischistosomal drug (praziquantel) has been examined, schistosomiasis induced brain oxidative stress as evidenced by the decrease of glutathione level, total antioxidant capacity and the activity of catalase significantly, while a significant elevation in the levels of nitrite/nitrate and malondialdhyde. In addition, the infection resulted in neurochemical disturbances, the main inhibitory amino acid, γ- aminobutyric acid level was decreased. In contrast, the level of chloride ions and acetylcholine esterase activity were significantly increased. Moreover, the histopathological section showed some impairments in the brain. The treatment with Morus alba leaves extract ameliorated the induced disturbances in schistosome-infected mice where the levels of non-enzymatic and enzymatic antioxidants were elevated. On the other hand, the levels of nitrite/nitrate and malondialdhyde were significantly reduced. Likewise, treatment of mice with Morus alba leaves extract improved the altered levels of γ- aminobutyric acid level and chloride ion. Also, it improved the recorded impairments of the histopathological section in the brain of schistosome infected mice. © 2014 Bentham Science Publishers.
Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: ENERGY.2013.2.9.1 | Award Amount: 6.30M | Year: 2013
The scientific targets of the EUROSUNMED project are the development of new technologies in three energy field areas, namely photovoltaics (PV), concentrated solar power (CSP) and grid integration (GI), in strong collaboration with research institutes, universities and SMEs from Europe in the north side of the Mediterranean sea and from Morocco and Egypt from the south of the sea. The focus in PV will be on thin film (Si, CZTS) based solar cells and modules while the goal in CSP field is to design and test new heliostats as well as novel solutions for energy storage compatible with these technologies. The project aims at producing components that will be tested under specific conditions of MPC (hot climate, absence of water, etc.). Such investigations are complemented with studies on grid integration of energy sources from PV and CSP in Morocco and Egypt context. Additionally, the consortium envisages to train PhD students and Post-Docs in these interdisciplinary fields in a close and fruitful collaboration between academic institutions and industry from EU and MPCs. The consortium is well placed around leading academic groups in materials science and engineering devices and equipments for the development of PV and CSP, and also in the promotion of the renewable energies in general. Moreover, technology transfer and research infrastructure development in the targeted areas will be provided. Disseminating the results of the projects will be done through the organization of summer schools, workshops and conferences towards large public from universities, engineering schools and stakeholders involved in the three selected energy areas and beyond. Another outreach of the project will be the proposal for a roadmap on the technological aspects (research, industry, implementation) of the PV, CSP and grid area as well as on the best practice for the continuation of strong collaboration between the EU and MPCS partners and beyond for for mutual interest and benefits.
Mohamed M.H.,Helwan University
Energy | Year: 2013
Wind energy represents a very important source of energy for many countries nowadays. Wind energy provides an efficient and an effective solution to reduce fusel fuel consumption as well as pollutant emissions. VAWTs (vertical axis wind turbines) were originally considered as very promising, before being subrogated by the present, horizontal axis turbines. There is now a resurgence of interests for VAWTs, in particular Darrieus turbines. VAWTs (vertical axis wind turbines) like the Darrieus turbine appear to be particularly promising for the conditions of low wind speed, but suffer from a low efficiency compared to horizontal axis turbines. Additionally, VAWTs are not always self-starting, which is a major drawback. The present paper introduces the main problem of the self-stating capability of Darrieus turbine and investigates some techniques to improve this drawback. The effect of the turbine solidity and the usage of hybrid system between drag and lift types have been investigated in this paper numerically using CFD (Computational Fluid Dynamics) technique and experimentally. A considerable improvement of the H-rotor Darrieus turbine self-starting capability can be obtained by these techniques. © 2013 Elsevier Ltd.
Abdel Moneim A.E.,Helwan University
Metabolic Brain Disease | Year: 2015
The central nervous system is one of the most vulnerable organs affected by mercury toxicity. Both acute and chronic exposure to mercury is also known to cause a variety of neurological or psychiatric disorders. Here, the neuroprotective effect of berberine (BN; 100 mg/kg bwt) on mercuric chloride (HgCl2; 0.4 mg/kg bwt) induced neurotoxicity and oxidative stress was examined in rats. Adult male albino Wistar rats were injected with HgCl2 for 7 days. HgCl2 treatment induced oxidative stress by increasing lipid peroxidation (LPO) and nitrite/nitrate (nitric oxide; NO) production along with a concomitant decrease in glutathione (GSH) and various antioxidant enzymes, namely superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Pretreatment of rats with BN inhibited LPO and NO production, whereas it increased GSH content. Activities of antioxidant enzymes were also restored concomitantly when compared to the control rats after BN administration. Berberine also caused decrease in TNF-α level and caspase-3 activity which was higher with HgCl2. Furthermore, treatment with BN inhibited apoptosis, as indicated by the reduction of Bax/Bcl-2 ratio in brain tissue. These data indicated that BN augments antioxidant defense with anti-inflammatory and anti-apoptotic activities against HgCl2-induced neurotoxicity and provides evidence that it has a therapeutic potential as neuroprotective agent. © 2015 Springer Science+Business Media New York.
Dkhil M.A.,Helwan University
Parasitology Research | Year: 2013
Coccidiosis and helminthosis in poultry are responsible for worldwide economic losses. The methanolic extract of Punica granatum (pomegranate) peel was used in vivo for its pharmacological, antioxidant and anti-coccidial properties and in vitro for its anthelmintic activity. For the in vivo study, four groups of mice were investigated. The first group was inoculated only with sterile saline and served as the control group. The second group was treated by oral gavage with pomegranate extract (300 mg/kg) daily for 5 days. The third and fourth groups were infected with 103 sporulated oocysts of Eimeria papillata. The fourth group was also treated once daily with pomegranate peel extract for 5 days. For the in vitro study, the anthelmintic effect of pomegranate peel extract was observed on live adult Allolobophora caliginosa. Paraffin sections from jejunum as well as jejunal homogenate were prepared for the histopathological and biochemical investigations, respectively. The data showed that mice infected with E. papillata revealed an output of approximately 2.9 × 105 oocysts per gram faeces on day 5 p.i. This output is significantly decreased to 50 % in pomegranate-treated mice. Infection with E. papillata induced marked histopathological alterations in jejunum in the form of inflammation, vacuolation of the epithelium and destruction of some villi. In addition, pomegranate extract caused a great diminish in body weight loss of infected mice. Moreover, the number of goblet cells stained with Alcian blue within the infected villi was significantly increased by about 26 % after pomegranate treatment. In addition, Pomegranate significantly lowered the increased number of apoptotic cells due to E. papillata infection by about 36 %. The results showed that E. papillata enhanced hydrogen peroxide, lipid peroxidation and nitric oxide production with concomitant reduction in glutathione. Pomegranate induced marked improvements in all of the studied parameters as well as the histopathological features of jejunum. In addition, pomegranate was able to exert a significant anthelmintic effect on live adult A. caliginosa worms in terms of the paralysis and death of the worms at different concentrations (100, 200 and 300 mg/ml). The study revealed that pomegranate as a natural product has protective effects against E. papillata-induced coccidiosis as well as it possesses an anthelmintic activity. © 2013 Springer-Verlag Berlin Heidelberg.
Mohamed M.H.,Helwan University
Energy | Year: 2014
The problems aided with wind turbine noise have been one of the more studied environmental influence areas in wind energy engineering. Noise levels can be measured, but, similar to other environmental attentions, the public's perception of the noise impact of wind turbines is in part a subjective determination. The author investigated in this work the aerodynamic acoustics of one type of the VAWT (vertical axis wind turbine) which called Darrieus turbine. Darrieus turbine is suitable to be established within the densely populated city area. Therefore, the noise item is very important to investigate. In this work, Darrieus rotor has been studied numerically and aerodynamically to obtain the generated noise from blades. This work offers a method based on the FW-H (Ffowcs Williams and Hawkings) equations and its integral solutions. Time-accurate solutions can be obtained from URANS (unsteady Reynolds-averaged Navier-Stokes) equations. Blade shape, tip speed ratio and solidity effects have been studied in this work. The results indicated that the higher solidity and higher tip speed ratio rotors are more noisy than the normal turbines. © 2013 Elsevier Ltd.
Mohamed M.H.,Helwan University
Energy | Year: 2012
Since millenaries humans have attempted to harness the wind energy through diverse means. Vertical axis wind turbines (VAWTs) were originally considered as very promising, before being superseded by the present, horizontal axis turbines. For various reasons, there is now a resurgence of interests for VAWTs, in particular Darrieus turbines. Using modern design tools and computational approaches, it should be possible to increase considerably the performance of traditional VAWTs, reaching a level almost comparable to that of horizontal axis turbines. Since VAWTs show many specific advantages (compact design, easier connection to gears/generator, easier blade control if needed, lower fatigue...), it is important to check quantitatively the efficiency of such turbines. This is the purpose of the present work, starting from the standard, straight Darrieus turbine (H-rotor). The aerodynamic investigation will be carried out for 20 different airfoils (Symmetric and Non-symmetric) by two-dimensional Computational Fluid Dynamics in order to maximize output torque coefficient and output power coefficient (efficiency). A considerable improvement of the H-rotor Darrieus turbine performance can be obtained in this manner. © 2012 Elsevier Ltd.
Eissa M.M.,Helwan University
IEEE Transactions on Smart Grid | Year: 2012
Distributed generation is expected to increase sharply as more and more renewable are integrated to power system with the realization of smart grid, consequently complex distribution smart grid is given. The traditional protection devices cannot be able to protect complex power system configuration due to many fault current loops will feed the fault point. Relays based on standalone decisions cannot provide reliable and correct action when used on a complex distribution system. This paper proposes new protection philosophy using wireless technology. Data sharing among relays to obtain reliable and accurate decision are introduced. Wireless Token Ring Protocol (WTRP) as a wireless local area network (LAN) protocol inspired by the IEEE 802.4 Token Bus Protocol is used for data sharing. WTRP is selected to improve efficiency by reducing the number of retransmissions due to collisions. WTRP architecture and protocol are described to verify operation. MATLAB simulation program is used to simulate the data exchange protocol between relays in a ring for a specified amount of time. © 2010-2012 IEEE.
Moneim A.E.A.,Helwan University
Current Alzheimer Research | Year: 2015
Alzheimer's disease (AD) is the most common form of dementia characterized by progressive loss of memory and other cognitive functions among older people. Senile plaques and neurofibrillary tangles are the most hallmarks lesions in the brain of AD in addition to neurons loss. Accumulating evidence has shown that oxidative stress–induced damage may play an important role in the initiation and progression of AD pathogenesis. Redox impairment occurs when there is an imbalance between the production and quenching of free radicals from oxygen species. These reactive oxygen species augment the formation and aggregation of amyloid-β and tau protein hyperphosphorylation and vice versa. Currently, there is no available treatments can modify the disease. However, wide varieties of antioxidants show promise to delay or prevent the symptoms of AD and may help in treating the disease. In this review, the role of oxidative stress in AD pathogenesis and the common used antioxidant therapies for AD will summarize. © 2015 Bentham Science Publishers.