Helmholtz Research Institute of Eye Diseases

Moscow, Russia

Helmholtz Research Institute of Eye Diseases

Moscow, Russia
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Kalamkarov G.R.,RAS Emanuel Institute of Biochemical Physics | Konstantinova T.S.,RAS Emanuel Institute of Biochemical Physics | Bugrova A.E.,RAS Emanuel Institute of Biochemical Physics | Shevchenko T.F.,RAS Emanuel Institute of Biochemical Physics | And 3 more authors.
Biophysics | Year: 2010

The possibility and the mechanism of the reduction of nitrites in retinal vessels under acute hypoxia in vivo have been investigated. An experimental model of rat retinal ischemia was elaborated using laser coagulation of retinal vessels. It was demonstrated that vessel thrombosis does not occur if the nitrite concentration in the vessels is increased. It was proposed that, under acute hypoxia, nitrites are reduced to NO, which results in drastic vasodilatation. Considering that the effect takes less than a minute, this reduction cannot be due to hypoxic acidosis but is more likely associated with NO reduction by heme proteins. It was found that increased concentration of nitrites protects the retina from the development of ischemia progress and that preliminary administration of nitrites prevents apoptosis in the retina and a decrease in its photoelectric activity. © 2010 Pleiades Publishing, Ltd.


Simpson E.R.,Princess Margaret Hospital Sick Kids Hospital | Gallie B.,Princess Margaret Hospital Sick Kids Hospital | Laperrierre N.,Princess Margaret Hospital Sick Kids Hospital | Beiki-Ardakani A.,Princess Margaret Hospital Sick Kids Hospital | And 42 more authors.
Brachytherapy | Year: 2014

Purpose: To present the American Brachytherapy Society (ABS) guidelines for plaque brachytherapy of choroidal melanoma and retinoblastoma. Methods and Materials: An international multicenter Ophthalmic Oncology Task Force (OOTF) was assembled to include 47 radiation oncologists, medical physicists, and ophthalmic oncologists from 10 countries. The ABS-OOTF produced collaborative guidelines, based on their eye cancer-specific clinical experience and knowledge of the literature. This work was reviewed and approved by the ABS Board of Directors as well as within the journal's peer-reivew process. Results: The ABS-OOTF reached consensus that ophthalmic plaque radiation therapy is best performed in subspecialty brachytherapy centers. Quality assurance, methods of plaque construction, and dosimetry should be consistent with the 2012 joint guidelines of the American Association of Physicists in Medicine and ABS. Implantation of plaque sources should be performed by subspecialty-trained surgeons. Although there exist select restrictions related to tumor size and location, the ABS-OOTF agreed that most melanomas of the iris, ciliary body, and choroid could be treated with plaque brachytherapy. The ABS-OOTF reached consensus that tumors with gross orbital extension and blind painful eyes and those with no light perception vision are unsuitable for brachytherapy. In contrast, only select retinoblastomas are eligible for plaque brachytherapy. Prescription doses, dose rates, treatment durations, and clinical methods are described. Conclusions: Plaque brachytherapy is an effective eye and vision-sparing method to treat patients with intraocular tumors. Practitioners are encouraged to use ABS-OOTF guidelines to enhance their practice. © 2014 American Brachytherapy Society.


Sokol E.V.,Va Nasonova Research Institute Of Rheumatology | Vasilyev V.I.,Va Nasonova Research Institute Of Rheumatology | Kovrigina A.M.,Hematology Research Center | Safonova T.N.,Helmholtz Research Institute of Eye Diseases | Nasonov E.L.,Va Nasonova Research Institute Of Rheumatology
Terapevticheskiĭ arkhiv | Year: 2015

IgG4-related disease (IgG4-RD) is a systemic immune-related disease that may involve the pancreas, liver, retroperitoneal space, biliary tract, salivary and lacrimal glands, eye socket, lung, and kidney. In term of pathomorphogenesis, it is a fibroinflammatory disease manifesting as a tumor-like lesion of organs, elevated serum IgG4 levels, and a morphofunctional substrate - the development of marked fibrosis and lymphoplasmacytic infiltration in the tissues with the high content of IgG4-positive plasma cells. The detection of a tumor-like nodule frequently leads to that the patients with IgG4-RD undergo major traumatic surgery for presumed cancer. At the same time, a number of investigations show the association of IgG4-RD with the development of cancer and lymphoproliferative diseases. The paper describes two clinical cases: Russia's first diagnosis of MALT lymphoma of the lacrimal gland, IgG4-positive and IgG4-RD with a rare onset with a destruction focus in the cervical vertebrae, multiple organ dysfunction, B-cell clonality in salivary gland tissue and PIgMκ secretion. It also reviews world literature on the development of lymphoproliferative diseases in the presence of IgG4-RD.Abstract available from the publisher.


PubMed | Va Nasonova Research Institute Of Rheumatology, Helmholtz Research Institute of Eye Diseases and Hematology Research Center
Type: Case Reports | Journal: Terapevticheskii arkhiv | Year: 2016

IgG4-related disease (IgG4-RD) is a systemic immune-related disease that may involve the pancreas, liver, retroperitoneal space, biliary tract, salivary and lacrimal glands, eye socket, lung, and kidney. In term of pathomorphogenesis, it is a fibroinflammatory disease manifesting as a tumor-like lesion of organs, elevated serum IgG4 levels, and a morphofunctional substrate - the development of marked fibrosis and lymphoplasmacytic infiltration in the tissues with the high content of IgG4-positive plasma cells. The detection of a tumor-like nodule frequently leads to that the patients with IgG4-RD undergo major traumatic surgery for presumed cancer. At the same time, a number of investigations show the association of IgG4-RD with the development of cancer and lymphoproliferative diseases. The paper describes two clinical cases: Russias first diagnosis of MALT lymphoma of the lacrimal gland, IgG4-positive and IgG4-RD with a rare onset with a destruction focus in the cervical vertebrae, multiple organ dysfunction, B-cell clonality in salivary gland tissue and PIgM secretion. It also reviews world literature on the development of lymphoproliferative diseases in the presence of IgG4-RD.


Nikolskaya I.I.,Moscow State University | Beznos O.V.,Helmholtz Research Institute of Eye Diseases | Galitskiy V.A.,Moscow State University | Chesnokova N.B.,Helmholtz Research Institute of Eye Diseases | Kost O.A.,Moscow State University
Moscow University Chemistry Bulletin | Year: 2016

A method for the preparation of calcium phosphate particles is optimized. Particles with entrapped superoxide dismutase are obtained. The size, surface charge, and stability of the calcium phosphate particles are determined under different conditions. The kinetics of the enzyme release from the particles and the influence of the drug release on the size and surface charge of the particles are investigated. On the rabbit model of immunogenic uveitis (the model of an inflammatory process in the eye accompanied by oxidative stress), it is shown that superoxide dismutase enclosed in calcium phosphate particles has a higher antiinflammatory effect than superoxide dismutase in an aqueous solution. © 2016, Allerton Press, Inc.


Danilov N.A.,Moscow State University | Ignatieva N.Y.,Moscow State University | Iomdina E.N.,Helmholtz Research Institute of Eye Diseases | Arutyunyan L.L.,Helmholtz Research Institute of Eye Diseases | And 2 more authors.
Biophysics | Year: 2011

It has been shown that the collagen content and denaturation temperature in scleral tissue increase during the development of glaucoma whereas the fluorescence intensity does not change. These effects may be related to the disturbance of collagen catabolism. © 2011 Pleiades Publishing, Ltd.

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