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Khoroshilova-Maslova I.P.,Helmholtz Moscow Research Institute of Ocular Diseases | Leparskaya N.L.,Helmholtz Moscow Research Institute of Ocular Diseases | Nabieva M.M.,Helmholtz Moscow Research Institute of Ocular Diseases | Andreeva L.D.,Helmholtz Moscow Research Institute of Ocular Diseases
Bulletin of Experimental Biology and Medicine

A model of proliferative vitreoretinopathy induced by simultaneous intravitreal injection of recombinant IL-1β and platelet concentrate is created and its main morphological manifestations are studied on Chinchilla rabbits. The model reflects pathogenesis of proliferative vitreoretinopathy: epiretinal membrane with the formation of retinal plication, traction detachment of the retina; moderate inflammatory reaction in the uveal tract, in the optic nerve infundibulum, in the vitreous body; intact structural elements of the retina, dissociation of the retinal pigmented epithelium cells with their subsequent migration. The model is adequate to the clinical picture of proliferative vitreoretinopathy in humans, which recommends it for experimental studies of the efficiency of drug therapy and prevention of this disease. © 2015, Springer Science+Business Media New York. Source

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