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Ymittos Athens, Greece

Vassiliadou I.,Greek National Center For Scientific Research | Costopoulou D.,Greek National Center For Scientific Research | Ferderigou A.,Hellenic Anticancer Institute | Leondiadis L.,Greek National Center For Scientific Research
Chemosphere | Year: 2010

The production of perfluorinated compounds which finds application in a wide variety of consumer products has led to their accumulation in the environment. This fact, in combination with their chemical properties of amphiphilicity and chemical stability is the cause of their occurrence in human tissues, which according to reports is widespread, not only in occupationally exposed workers, but also in the general population. In this study, we analyzed 182 blood samples from three different groups of adults living in Greece, in order to evaluate blood levels of two environmentally most common perfluorinated compounds, perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA). The samples examined were from a group of individuals living in Athens, a group of inhabitants of the semi-urban and rural area of Argolida, and a group of cancer patients from the St. Savas Anticancer Hospital in Athens. The latter group was chosen in order to examine the possible relation of PFOS and PFOA levels with cancer incidence in the general population. The analytical results showed the presence of PFOS and PFOA in all samples examined, at levels similar to those reported from other European countries. There was no significant difference between the three groups however there was a significant difference between the levels of men and women in all groups examined. No correlation was found between age and PFOS and PFOA levels. This is the first study of this kind to be conducted in samples from Greece. © 2010 Elsevier Ltd.

Fusaroli P.,University of Bologna | Kypreos D.,Hellenic Anticancer Institute | Alma Petrini C.A.,University of Bologna | Caletti G.,University of Bologna
Journal of Clinical Gastroenterology | Year: 2011

The literature about endoscopic ultrasonography (EUS) is still very prolific although it was introduced in the early 1980s. We aimed to review last decade's scientific production and to compare it with our earlier data about the period from 1980 to 2000. EUS publications of the period January 2001 to January 2010 were retrieved. Reviews, prospective, and retrospective studies, randomized controlled trials, meta-analyses, surveys, guidelines, and case-series were assessed. Data were collected on the subject-matter, type of publication, number of patients included, publishing journal, most recent impact factor, year of publication, and country accredited for publication. A total of 1763 relevant papers were published in more than 250 journals. The main areas of research were pancreatic disorders, tumors of the gastrointestinal wall, the extrahepatic biliary tree, submucosal lesions, lung cancer, and mediastinal masses. It is interesting to note that the therapeutic applications of EUS accounted for a new field of investigation. The majority of articles comprised retrospective trials and reviews, followed by prospective studies and case series. However, a considerable number of randomized controlled trials and meta-analyses was retrieved, which were absent in the earlier survey. United States, Europe, and Japan still possessed a pivotal role on EUS research, but an increasing number of publications has also emerged from other countries. The available literature on EUS keeps expanding, encompassing not only its well-established diagnostic role, but also novel indications and therapeutic interventions. EUS has evolved into a valuable implement of modern clinical practice, with a critical effect on patients' management. A trend toward well-structured studies is evident. Copyright © 2011 by Lippincott Williams & Wilkins.

Xinopoulos D.,Hellenic Anticancer Institute | Bassioukas S.P.,Hellenic Anticancer Institute | Kypreos D.,Hellenic Anticancer Institute | Korkolis D.,Hellenic Antican cer Institute Saint Savvas Hospital of Athens | And 4 more authors.
World Journal of Gastroenterology | Year: 2011

AIM: To investigate the technical success and clinical complication rate of a cannulated pancreatic duct with guidewire for biliary access. METHODS: During a five-year study period, a total of 2843 patients were included in this retrospective analysis. Initial biliary cannulation method consisted of single-guidewire technique (SGT) for up to 5 attempts, followed by double-guidewire technique (DGT) when repeated unintentional pancreatic duct cannulation had taken place. Pre-cut papillotomy technique was reserved for when DGT had failed or no pancreatic duct cannulation had been previously achieved. Main outcome measurements were defned as biliary cannu-lation success and post-endoscopic retrograde cholan-giopancreatography (ERCP) complication rate. RESULTS: SGT (92.3% success rate) was characterized by statistically significant enhanced patient outcome compared to either the DGT (43.8%, P < 0.001), pre-cut failed DGT (73%, P < 0.001) or pre-cut as first step method (80.6%, P = 0.002). Pre-cut as first step method offered a statistically significantly more favorable outcome compared to the DGT (P < 0.001). The incidence of post-ERCP pancreatitis did not differ in a statistically significant manner between either method (SGT: 5.3%, DGT: 6.1%, Pre-cut failed DGT: 7.9%, Pre-cut as first step: 7.5%) or with patients' gender. CONCLUSION: Although DGT success rate proved not to be superior to SGT or pre-cut papillotomy, it is considered highly satisfactory in terms of safety in order to avoid the risk of a pre-cut when biliary therapy is necessary in difficult-to-cannulate cases. © 2011 Baishideng. All rights reserved.

Piperis M.,St Savvas Hospital | Provatopoulou X.,Hellenic Anticancer Institute | Sagkriotis A.,Hellenic Anticancer Institute | Kalogera E.,Hellenic Anticancer Institute | And 4 more authors.
Anticancer Research | Year: 2012

Background: The aim of this study was to investigate the effect of breast cancer adjuvant therapies on the levels of circulating surfactant protein-D (SP-D), C-Reactive protein (CRP) and soluble receptor for advanced glycation end-products (sRAGE), as potential biomarkers of subclinical pulmonary inflammation. Materials and Methods: The soluble molecules were serially determined in 38 patients, prior to the initiation of radiation therapy (RT) and during adjuvant treatment, using immunoassays. Results: Significantly higher levels of all three biomarkers were observed in patients prior to the initiation of RT compared to healthy controls (CRP: p<0.001, SP-D: p<0.05, sRAGE: p<0.05). SP-D levels exhibited a gradual increase after RT and during follow-up (p<0.005). Patients treated with a combination of RT and hormonal therapy presented a significant, but less pronounced, increase in SP-D and a significant decrease in CRP compared to those who did not receive hormonal therapy (p=0.0428 and p=0.0116, respectively). Patients treated with a combination of RT and trastuzumab presented a significant increase in SP-D levels (p=0.0310). Conclusion: The average rate of change in the levels of circulating SP-D and CRP during postoperative irradiation and adjuvant hormonal therapy suggests that the combined therapeutic regiment may potentially exert important anti-inflammatory effects on the lung. On the contrary, combined administration of RT and trastuzumab is likely to induce or provoke pulmonary inflammation.

Kapritsou M.,Hellenic Anticancer Institute | Korkolis D.P.,Hellenic Anticancer Institute | Konstantinou E.A.,National and Kapodistrian University of Athens
Gastroenterology Nursing | Year: 2013

Laparoscopic surgery for colorectal cancer has been used with success since 1991. During the last decade, many studies have compared laparoscopic surgery with open colectomy. The aim of this retrospective study was to present the advantages and disadvantages of laparoscopic and open colectomy for cancer, focusing on the postoperative care of patients. Eighty-eight consecutive patients suffering from cancer of the colon and rectum, surgically treated, were studied. They were divided into 2 groups: Group A patients (n = 48) underwent laparoscopic colectomy, and Group B patients (n = 40) were treated with an open procedure. For postoperative care of the patients, analgesia, median hospital stay, overall cost, and complications between the 2 groups were studied and statistically compared. Laparoscopic colectomy was associated with a shorter average hospital stay, fewer complications, earlier start of a normal diet, and better control of postoperative pain. Nonetheless, the cost of surgical instruments used in laparoscopic operation is higher. Laparoscopic surgery, despite its higher cost, seems to add significant advantages in the postoperative recovery of patients suffering from colorectal cancer. Copyright © 2013 Society of Gastroenterology Nurses and Associates.

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