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Kowalzick L.,Klinik fur Hautkrankheiten und Allergologie | Marcus E.L.,HELIOS Vogtland Klinikum Plauen GmbH | Kehler B.,Klinik fur Hautkrankheiten und Allergologie | Kehler T.,Klinik fur Kinder und Jugendmedizin | Truhm B.,Klinik fur Hautkrankheiten und Allergologie
Aktuelle Dermatologie | Year: 2014

We report on a 9-year-old girl with skin type I according to Fitzpatrick, who developed for the first time infiltrated erythema partly covered by yellowish crusts in her face and on her helices immediately following first intense insolation in spring and presented disseminated papulovesicular lesions. An infection with EBV could not be found in serology. A porphyria could be ruled out. The eruption almost completely cleared under mild topical corticosteroids within five days. We made the diagnosis of Hydroa vacciniforme showing also clinical or demographic features of actinic prurigo and juvenile spring eruption. The differential diagnosis of these diseases is discussed in the light of the literature. © Georg Thieme Verlag KG.


We report on a male caucasian 56-year-old patient who developed squamous cell carcinoma of the keratoacanthoma type five years after de novo occurrence of cutaneous malignant melanoma at the end of a 30 month period of treatment with TNF-alpha-antagonists. Because of a recalcitrant moderate to severe plaque psoriasis he consecutively received infliximab, adalimumab and etanercept. The patient before was treated over a period of 4 years with fumarates, and for 2 months with ciclosporine A and for 5 weeks with methotrexate. Two cycles of cream PUVA and UVB radiations have been applied before, respectively between systemic medications. Since the diagnosis of malignant melanoma further UV- and systemic immunosuppressive therapy was abolished and the psoriasis treated topically with calcipotriol and betamethasonvalerate. A possible causal connection between development of keratoacanthoma and immunosuppressive treatments is discussed in the light of recent literature. © Georg Thieme Verlag KG Stuttgart - New York.


We report on a male caucasian 56-year-old patient who developed squamous cell carcinoma of the keratoacanthoma type five years after de novo occurrence of cutaneous malignant melanoma at the end of a 30 month period of treatment with TNF-alpha-antagonists. Because of a recalcitrant moderate to severe plaque psoriasis he consecutively received infliximab, adalimumab and etanercept. The patient before was treated over a period of 4 years with fumarates, and for 2 months with ciclosporine A and for 5 weeks with methotrexate. Two cycles of cream PUVA and UVB radiations have been applied before, respectively between systemic medications. Since the diagnosis of malignant melanoma further UV- and systemic immunosuppressive therapy was abolished and the psoriasis treated topically with calcipotriol and betamethasonvalerate. A possible causal connection between development of keratoacanthoma and immunosuppressive treatments is discussed in the light of recent literature. © Georg Thieme Verlag KG Stuttgart. New York.


Kowalzick L.,HELIOS Vogtland Klinikum Plauen GmbH | Ehrich D.,HELIOS Vogtland Klinikum Plauen GmbH | Ponnighaus J.-M.,HELIOS Vogtland Klinikum Plauen GmbH
Aktuelle Dermatologie | Year: 2011

We report on a nearly 3-years old caucasian girl with atopic diathesis, who developed a strongly itching bizarre configured linear eczematous generalized skin lesions following Blaschko's lines sparing the face 3 weeks after a febrile infection. We made the diagnosis of juvenile blaschkitis. The nosology and classification of this possible entity is discussed in the view of the literature. © Georg Thieme Verlag KG Stuttgart - New York.


Kowalzick L.,HELIOS Vogtland Klinikum Plauen GmbH | Wickenhauser C.,University of Leipzig | Hammerschmidt D.,HELIOS Vogtland Klinikum Plauen GmbH | Pfeiffer A.-K.,HELIOS Vogtland Klinikum Plauen GmbH | And 2 more authors.
Aktuelle Dermatologie | Year: 2012

We report on a 91-years old male caucasian patient with multiple partly centrally depressed polycyclic or strongly margin stressed, erythematous skin lesions, generalized with the exception of the face, since ten years existing. The diagnosis of an annular elastolytic giant cell granuloma (AEGCG) was made by histology. In parallel, a newly detected diffuse B-cell lymphoma stage IVA Ann-Arbor classification with multiple lymph node, spleen and bone marrow involvement was diagnosed. During a therapy with rituximab the lymphoma responded well within 5 weeks, but the skin lesions did not improve markedly. © 2012 Georg Thieme Verlag KG Stuttgart • New York.

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