Zhao W.-T.,Cangzhou Medical College |
Li P.-P.,Infectious Disease Hospital of Cangzhou |
Zhang H.-F.,Cangzhou Medical College |
Wu N.-P.,Peoples Hospital Of Hejian |
Liang J.-F.,Peoples Hospital Of Hejian
Chinese Journal of Tissue Engineering Research | Year: 2015
BACKGROUND: In recent years, the effectiveness of stem cell transplantation in the treatment of spinal cord injury has been validated in animal models, and mesenchymal stem cell transplantation for treatment of spinal cord injury has been studied most widely. Currently, there are a number of relevant clinical studies that have shown a good prospect. OBJECTIVE: To evaluate the efficacy and safety of mesenchymal stem cell transplantation for spinal cord injury in human with a system review. METHODS: PubMed database, EMBASE database, Cochrane Library, ISI Web of knowledge, CBM database, VIP database, CNKI database and Wanfang database were searched from their start year up to July 2015 for relevant randomized clinical trials on the treatment of spinal cord injury with mesenchymal stem cell transplantation. The key words were “spinal cord injury, paraplegia, cell transplantation, transplantation, mesenchymal stem cell, bone marrow transplantation, stem cell, randomized controlled trial” in English and Chinese, respectively. RESULTS AND CONCLUSION: A total of 260 articles were retrieved, including 6 randomized clinical trials (252 cases). In the aspects of ASIA touch sensation score, overall Frankel score and daily life activity training score, the patients undergoing mesenchymal stem cell transplantation were significantly superior to those in the control group (P < 0.05). In addition, ASIA motor function score and residual urine volume were also improved in the patients undergoing mesenchymal stem cell transplantation, but there was no statistical difference (P > 0.05). Compared with the control group, low fever was more common in the patients undergoing mesechymal stem cell transplantation (P < 0.05). Another side effect was lower limb numbness, but there was no difference from the control group (P > 0.05). These findings suggest that mesenchymal stem cell transplantation has limited efficacy in the treatment of spinal cord injury and cannot induce severe complications, but there is a need for high-quality randomized controlled trials to prove the efficiency and safety of mesenchymal stem cell transplantation for the treatment of spinal cord injury. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.