Heilongjiang Provincial Peoples Hospital
He J.,Capital Medical University |
Wang J.,Capital Medical University |
Zhou Y.,Capital Medical University |
Fu Y.,Capital Medical University |
And 9 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2017
The aim of this study was to compare the efficiency and safety of urapidil and nitroglycerin in treating elderly patients with acute heart failure. A total of 248 patients with acute heart failure were recruited randomly from 10 clinical centers. In this article, efficiency of medication to elderly patients (age ≥60 yrs., n = 222) was specially focused. Patients were administrated with urapidil (n = 107) or nitroglycerin (n = 115) by micro-pump continuously for 48 hours. Compared with nitroglycerin, urapidil significantly increased ejection fraction (EF%), decreased left ventricular end diastolic volume (EDV) and end systolic volume (ESV). No significant difference of NT-pro BNP was detected (2-day: ESV, P = 0.067; EDV, P = 0.016; EF%, P = 0.054; NT-pro BNP, P = 0.853; 7-day: ESV, P = 0.039; EDV, P = 0.054; EF%, P = 0.035; NT-pro BNP, P = 0.931); Urapidil provided significantly lipid-decreasing effects, and showed no disadvantage effects on blood glucose (⊿2d: cholesterol, P = 0.016; LDL, P = 0.031; blood glucose, P = 0.613; ⊿7d: cholesterol, P = 0.012; LDL, P = 0.059; blood glucose, P = 0.422); More severely deteriorated baseline renal function was observed in urapidil group (P = 0.024), however, the increase amplitude of creatinine was comparable at all tested time points between the two groups (⊿2d: P = 0.692; ⊿7d: P = 0.742); And 30-day incidence of re-hospitalization and deterioration of cardiac function was significantly lower in urapidil group (P = 0.046). Therefore, urapidil more effectively reduces cardiac load and improves cardiac function, while providing more significant protection to renal function and improving blood lipid metabolism. We recommended that urapidil should be preferably used for elderly patients with acute heart failure as an effective and safe vasodilator. © 2017, E-Century Publishing Corporation. All rights reserved.
Peng Z.,Centers for Disease Control and Prevention |
Xu J.,Heilongjiang Provincial CDC |
Yu Z.,Zhejiang Provincial CDC |
Sun Q.,Hunan Provincial CDC |
And 20 more authors.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2015
OBJECTIVE: To identify clinical characteristics of hospitalized laboratory-confirmed influenza cases of children under 15 years old, and their risk factors of influenza infection.METHODS: Analyzing the reports of hospitalized laboratory-confirmed influenza cases of children under 15 years old who were detected by the sentinel surveillance systems in 10 provinces from December 2009 to June 2014. Such data as their demographic, medical history, clinical symptoms and signs, treatment and outcome were collected using questionnaires, with their clinical characteristics and their risk factors of influenza infection described.RESULTS: Of the 2 937 severe acute respiratory infection inpatients, 190 (6.5%) were laboratory-confirmed influenza cases. 123 (64.7%) of such confirmed cases were male, and 139 (73.2%) were children under 5 years old, with age median of 3.0 years (IQR: 1.0-5.0 years). 20 (10.5%) of them had at least one chronic medical condition, mostly chronic cardiovascular disease (3.2%), immunosuppressive disease (3.2%), and cancer/tumor (2.6%). Most common clinical symptoms of the cases were fever (92.6%) and cough (88.8%), of which abnormal pulmonary auscultation (51.1%) and abnormal chest X-ray performance (36.1%) were the most common clinical signs. 29 cases (15.8%) had complications, of which pneumonia (15.3%) was most common. 16 cases (8.6%) used antiviral drugs, and 4 cases (2.2%) were admitted into ICU. Risk factor analysis suggested that age < 6 months (OR = 0.406, 95% CI: 0.203-0.815) was a protective factor against influenza infection; and age 5-9 years old (OR = 2.535, 95% CI: 1.059-6.066) was a risk factor for influenza infection.CONCLUSION: Hospitalized laboratory-confirmed influenza cases were found mostly in children under 5 years old. Risk exposure for influenza infection varied among age groups.