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Xiaoyen Zheng, Ph.D., will begin her latest research to understand the mechanisms behind the Hedgehog receptor in May 2017 WASHINGTON (May 4, 2017)-- Among scientists specializing in the area, the mechanisms behind the signaling function of the Hedgehog (Hh) receptor pathway remain a mystery. Xiaoyen Zheng, Ph.D., assistant professor of anatomy and regenerative biology at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), who recently received a $1.7 million grant from the National Institutes of Health and National Institute of General Medical Sciences, is determined to learn more about the Hh pathway. With this funding, Zheng will develop a comprehensive understanding of the pathway's underlying mechanisms. Previous research has shown that the Hh receptor, Patched, regulates pathway activity. Studies have also shown that Hh pathway components are trafficked through the cilium of cells. This led Zheng to look at the possibility of ciliary trafficking as a crucial regulation point for the Patched component. The focus of her research is to look at the primary cilium's role as the cellular platform for the process. Over the course of the study, Zheng and her team will employ the use of both cell lines and mouse models. "A comprehensive understanding of the signal transduction will provide a better basis for the design and implementation of effective therapeutic approaches to diseases caused by malfunction of the Hh signaling pathway," Zheng said. The Hedgehog receptor plays an important role in embryonic development and adult stem cell function. A loss of signaling during development can result in birth defects, such as holoprosencephaly and congenital heart disease. Post-development loss is associated with a variety of cancer types. Zheng received seed funding from the GW School of Medicine and Health Sciences and from GW Cancer Center to begin her research. Her mentors and colleagues at SMHS also provided feedback during the proposal process. Zheng also gives credit to Peter Nemes, Ph.D., assistant professor of chemistry at the GW Columbian College of Arts and Sciences, who has collaborated on the proposed research. The project, titled "The Role of Ciliary Trafficking in Hedgehog Receptor Function" will be funded for a five-year period. Media: To interview Dr. Zheng, please contact Ashley Rizzardo at amrizz713@gwu.edu or 202-994-8679. Founded in 1824, the GW School of Medicine and Health Sciences (SMHS) was the first medical school in the nation's capital and is the 11th oldest in the country. Working together in our nation's capital, with integrity and resolve, the GW SMHS is committed to improving the health and well-being of our local, national and global communities. smhs.gwu.edu


News Article | November 28, 2016
Site: globenewswire.com

LEXINGTON, Mass., Nov. 28, 2016 (GLOBE NEWSWIRE) -- Curis, Inc. (Nasdaq:CRIS), a biotechnology company focused on the development and commercialization of innovative and effective drug candidates for the treatment of cancer, today announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has granted full approval to Erivedge® (vismodegib) for the treatment of adult patients with symptomatic metastatic basal cell carcinoma (BCC) or locally advanced BCC inappropriate for surgery or radiotherapy. Erivedge is also approved in the U.S. for the treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation. Erivedge was developed and is marketed by Roche and Genentech, a member of the Roche Group, under a collaboration agreement between Curis and Genentech.  Erivedge was originally granted ‘conditional approval’ in July, 2013 in the European Union (EU) and the authorization has now been converted from ‘conditional’ to ‘full approval’ based on the results from the STEVIE study that included 1215 patients with advanced BCC. STEVIE (MO25616) is a single-arm, open-label, Phase II, multicenter study that was conducted by Roche to assess the safety of vismodegib in patients with locally advanced and metastatic BCC. The safety and efficacy results of the STEVIE trial were consistent with the results of the pivotal study ERIVANCE BCC (SHH4476g) that supported the initial conditional approval of the drug in the EU. About Basal Cell Carcinoma and the Hedgehog Pathway According to the American Cancer Society, BCC accounts for approximately 80 percent of all diagnosed skin cancers. The disease is generally considered curable if the cancer is restricted to a small area of the skin. However, in a small group of people, if the disease is left untreated or recurs in the same location after surgery or radiotherapy, it may become locally advanced and invade further into surrounding areas such as sensory organs (ears, nose and eyes), bone, or other tissues. Depending on the location of the lesion, some cases of advanced BCC can be disfiguring, and treatment with surgery or radiation can lead to the loss of sensory organs and their functions such as eyesight or hearing. In a small proportion of patients, BCC can metastasize, spreading to other parts of the body. Abnormal signaling in the Hedgehog pathway is implicated in more than 90 percent of BCC cases. Erivedge is designed to selectively inhibit signaling in the Hedgehog pathway by binding to a protein called Smoothened. The Hedgehog signaling pathway plays an important role in regulating proper growth and development in the early stages of life and normally becomes less active in adults. The Hedgehog signaling pathway is implicated in the development of certain types of cancer, including BCC. In January 2012, Erivedge became the first licensed medicine for patients with advanced basal cell carcinoma when the U.S. Food and Drug Administration (FDA) approved it under the priority review program that provides for an expedited six-month review of drugs that offer major advances in treatment. Erivedge is approved in the U.S. for the treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation. Erivedge is currently approved and marketed in multiple countries worldwide. Erivedge is currently in development by Roche and Genentech in other diseases including idiopathic pulmonary fibrosis and myelofibrosis. Under the ongoing collaboration agreement between Genentech, a wholly owned member of the Roche Group, and Curis, Erivedge (vismodegib, GDC-0449, RG3616) was discovered by Genentech and was jointly validated by the parties through a series of preclinical studies. Pursuant to this collaboration, Genentech and Roche are responsible for clinical development, and Genentech (U.S.), Roche (Ex-U.S. excluding Japan) and Chugai Pharmaceuticals (Japan) are responsible for commercialization of Erivedge. Curis receives royalties on sales of Erivedge by Genentech/Roche. About Curis, Inc. Curis is a biotechnology company focused on the development and commercialization of innovative and effective drug candidates for the treatment of human cancers, including its lead development candidate, CUDC-907 that is being investigated in clinical studies in patients with lymphomas and solid tumors.  Curis is also engaged in a broad collaboration with Aurigene in the areas of immuno-oncology and precision oncology.  As part of this collaboration, Curis has exclusive licenses to oral small molecule antagonists of the PD-1 and VISTA pathways, including PD-L1/VISTA antagonist CA-170, and oral small molecule antagonists of the PD-1 and TIM-3 pathways, including PD-L1/TIM-3 antagonist CA-327, as well as to molecules designed to inhibit the IRAK4 kinase, including CA-4948.  CA-170 is currently undergoing testing in a Phase 1 trial in patients with advanced solid tumors and lymphomas. Curis is also party to a collaboration with Genentech, a member of the Roche Group, under which Genentech and Roche are commercializing Erivedge® for the treatment of advanced basal cell carcinoma, and are further developing Erivedge in other diseases including idiopathic pulmonary fibrosis and myelofibrosis. For more information, visit Curis's website at www.curis.com. Cautionary Note Regarding Forward-Looking Statements: This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including without limitation statements regarding the potential advantages and benefits of small molecule checkpoint inhibitors and the Company's plans and expectations for the collaboration with Aurigene, including its plans to discover and develop multiple first-in-class oral, small molecule checkpoint inhibitors for the treatment of patients with cancer. Forward-looking statements may contain the words "believes," "expects," "anticipates," "plans," "seeks," "estimates," "assumes," "will," "may," "could" or similar expressions. These forward-looking statements are not guarantees of future performance and involve risks, uncertainties, assumptions and other important factors that may cause actual results to be materially different from those indicated by such forward-looking statements. For example, Curis may experience adverse results, delays and/or failures in its drug development programs and may not be able to successfully advance the development of its drug candidates in the time frames it projects, if at all. Curis's drug candidates may cause unexpected toxicities, fail to demonstrate sufficient safety and efficacy in clinical studies and/or may never achieve the requisite regulatory approvals needed for commercialization. Favorable results seen in preclinical studies and early clinical trials of Curis's drug candidates may not be replicated in later trials. There can be no guarantee that the collaboration agreement with Aurigene will continue for its full term, that Curis or Aurigene will each maintain the financial and other resources necessary to continue financing its portion of the research, development and commercialization costs, or that the parties will successfully discover, develop or commercialize drug candidates under the collaboration. Regulatory authorities may determine to delay or restrict Genentech's and/or Roche's ability to continue to develop or commercialize Erivedge in BCC. Erivedge may not demonstrate sufficient or any activity to merit its further development in disease indications other than BCC. Competing drugs may be developed that are superior to Erivedge. Curis faces risks relating to its wholly-owned subsidiary's royalty-collateralized loan transaction, including the risk that it may not receive sufficient levels of royalty revenue from sales of Erivedge to satisfy the debt obligation or may otherwise lose its rights to royalties and royalty-related payments as a result of a foreclosure of the loan. Curis will require substantial additional capital to fund its business and such capital may not be available on reasonable terms, or at all. Curis faces substantial competition. Curis also faces risks relating to potential adverse decisions made by the FDA and other regulatory authorities, investigational review boards, and publication review bodies. Curis may not obtain or maintain necessary patent protection and could become involved in expensive and time-consuming patent litigation and interference proceedings. Unstable market and economic conditions and unplanned expenses may adversely affect Curis's financial conditions and its ability to access the substantial additional capital needed to fund the growth of its business. Important factors that may cause or contribute to such differences include the factors set forth under the caption "Risk Factors" in our in our most recent Form 10-K and Form 10-Q and the factors that are discussed in other filings that we periodically make with the Securities and Exchange Commission ("SEC"). In addition, any forward-looking statements represent the views of Curis only as of today and should not be relied upon as representing Curis's views as of any subsequent date. Curis disclaims any intention or obligation to update any of the forward-looking statements after the date of this press release whether as a result of new information, future events or otherwise, except as may be required by law.


Wrinch M.,Hedgehog | El-Fouly T.H.M.,CANMET Energy | Wong S.,CANMET Energy
IEEE Power and Energy Society General Meeting | Year: 2012

This paper presents and demonstrates a method to quickly identify when regular periodic activities, such as a daily night setback on a thermostat, are inappropriately configured or accidentally reset. Anomalies in periodic building operations are identified by analyzing smart meter electrical demand data in the frequency domain with a weekly travelling time window instead of using time domain functions such as load factor. Initial experiments on a real site found that spectral energy signals for periodic (frequency) hours of 4, 6, 8, 12 and days 1, 3.5 and 7 to be greatly reduced when a device is not functioning appropriately. In addition, the ratio of the DC offset (0 Hz) energy with the other higher periodic energies can normalize the periodic energies to a relative index that can then be used for comparing other seasons and other buildings for periodical performance. © 2012 IEEE.


Bassill P.,Hedgehog
Network Security | Year: 2013

When evaluating the risk of a data or system security breach, it's essential that one addresses the consequences in a comprehensive way. One of the most significant threats is the devaluation of the business itself and the impact on the company's reputation. The data breach or technical compromise is actually only the mechanism through which the threat is realised. © 2013 Elsevier Ltd.


Patent
Hedgehog | Date: 2015-04-29

The present invention discloses a bubble blowing device comprising a body; a bubble making unit horizontally located in the body for making bubbles by air flowing in the bubble making unit; a power supply disposed in the body; and a sound and/or light generating unit disposed in the body which is electrically connected to the power supply so that when air flows into the bubble making unit, the sound and/or light generating unit can be actuated to generate sound and/or light, while bubbles may be made by the bubble making unit simultaneously. Sound and/or light can be automatically carried out by adding a sound and/or light generating unit in the device, while bubbles with different sizes can be formed simultaneously. Thus, this device can be definitely more attractive than those in prior art.


Trademark
Hedgehog | Date: 2011-12-07

Yoga mats.


Trademark
Hedgehog | Date: 2013-08-29

Toffee.


Trademark
Hedgehog | Date: 2013-08-29

Toffee.


The invention relates to an energy distribution and consumption system comprising: a group of rail vehicles provided with regenerative braking means; a group of electrically powered bus vehicles each comprising an onboard battery; an electrical energy storage means adapted for storing electrical energy generated by a rail vehicle during braking thereof; a plurality of charging stations, each adapted for connecting to bus a vehicle, for charging the onboard battery thereof with electrical energy from said electrical energy storage means; wherein said group of rail vehicles is adapted for providing a substantially predetermined net supply of electrical energy to said electrical energy storage means during a predetermined time period, wherein said group of bus vehicles is adapted for substantially consuming at least said net amount of electrical energy within said predetermined time period.


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