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Dongguan, China

Zhang J.,HEC Pharm Group | Zhang Y.,HEC Pharm Group
Chinese Journal of Organic Chemistry | Year: 2013

The recent synthetic development and applications of mucochloric acid, mucobromic acid and their derivatives are described, mainly focus on our work using these multiple functional molecules to access a wide variety of γ-butenolides, γ-lactams, 4, 5-dihalopyridazin-3-ones and other novel, multi-functionalized building blocks and pharmaceutical products. © 2013 Chinese Chemical Society and SIOC, CAS. Source


Zhang J.,HEC Pharm Group | Nie B.,HEC Pharm Group | Zhang Y.,HEC Pharm Group
Chinese Journal of Organic Chemistry | Year: 2015

This article reviews the application and progress of modern synthetic methods to deliver several innovative drugs, especially the blockbusters, such as sofosbuvir, rivaroxaban, enzalutamide, canagliflozin and tofacitinib. Some of the modern synthetic methods, for example catalytic processes, application of ring-closing metathesis, palladium catalyzed cross-coupling, green chemistry and telescoping of processes, are highlighted. The exciting journey from discovering these new molecular entities, especially those which are first-in-class with the synthesis of a dozen of approved drugs, is described as case studies to fully illustrate the important role of modern organic synthesis for successful drug discovery and development. © 2015 Chinese Chemical Society & SIOC, CAS. Source


Zhang J.,HEC Pharm Group | Jin C.,HEC Pharm Group | Zhang Y.,HEC Pharm Group
Chinese Journal of Organic Chemistry | Year: 2014

This review outlines the recent advances of fluorinated drugs and latest research overview from the perspective of a medicinal chemist wherein the synthesis and use of trifluoromethylation, difluoromethylation, monofluoromethylation and fluorinated aromatic (heterocyclic) compounds are highlighted. It is pointed out that the full use of the latest progress in fluorine chemistry provides a shortcut to new fluorinated compounds or previously difficult to prepare compounds which is worth exploring for drug discovery. © 2014 Chinese Chemical Society & SIOC, CAS. Source


Zhang Y.,HEC Pharm Group | Nie B.,HEC Pharm Group | Zhang J.,HEC Pharm Group
Chinese Journal of Organic Chemistry | Year: 2015

The copper-catalyzed C-H activation, selective functionalization and the development of cyclization strategy for the synthesis of novel fused-heterocyclic (heterocycles with ring-junction nitrogen or bridgehead nitrogen) compounds are discussed. This class of novel bridgehead nitrogen heterocycles includes indolizine, pyrazolopyridine, benzimidazole and other polyheterocyclic compounds. The series including modern amination, oxidative coupling and Csp2-H, Csp-H, Csp3-H and N-H activation catalyzed by Cu(I) or Cu(II) salts makes this green synthesis a superior and practical method providing entry into complex heterocycles. Some reaction mechanisms have also been summarized. © 2015 Chinese Chemical Society & SIOC, CAS. Source

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