Jerusalem, Israel
Jerusalem, Israel

The Hebrew University of Jerusalem is Israel's second-oldest university, after the Technion. The Hebrew University has three campuses in Jerusalem and one in Rehovot. The world's largest Jewish studies library is located on its Edmond J. Safra Givat Ram campus.The first Board of Governors included Albert Einstein, Sigmund Freud, Martin Buber, and Chaim Weizmann. Four of Israel's prime ministers are alumni of the Hebrew University. In the last decade, seven researchers and alumni of the University received the Nobel Prize and one was awarded the Fields Medal.According to the Academic Ranking of World Universities, the Hebrew University is the top university in Israel, overall the 59th-best university in the world, 16th in mathematics, 27th in computer science and 44th in business/economics.In 2013, the Center for World University Rankings ranked the Hebrew University 21st in the world and the top in Israel in its World University Rankings, while another survey ranked it as the 9th best university to work in, and the 2nd best outside of the United States. Wikipedia.

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Hebrew University of Jerusalem | Date: 2016-09-12

The present invention relates to a poly(lactic glycolic) acid (PLGA) nanoparticle associated with therapeutic agents for a variety of therapeutic applications.

Hebrew University of Jerusalem and Hoffmann-La Roche | Date: 2016-09-08

Uses of a compound of any of Formulas I-VI as a cytotoxic inhibitor of undifferentiated cells are disclosed herein, as well as pharmaceutical compositions comprising a compound of any of Formulas I-VI, and methods for identifying a lead candidate for inhibiting undifferentiated cells. Further disclosed are uses of an SCD-1 inhibitor as a cytotoxic inhibitor of undifferentiated cells.

Hebrew University of Jerusalem | Date: 2016-10-13

The present invention is directed to phenyl substituted cyclohexenyl compounds, compositions comprising them and uses thereof for the preparation of medicaments for the treatment of obesity and any disease or disorder associated therewith, for reduction in food consumption, and for the treatment of inflammation and disorders associated therewith.

Hadasit Medical Research Services & Development Li Mited and Hebrew University of Jerusalem | Date: 2016-11-29

Provided is a device for iontophoretic delivery of a drug to or into a tissue, including an arrangement that prevents operation of the device at a current density that is higher than a predetermined value, the arrangement including first means responsive to a first data item, indicative of the surface area through which the current is to pass, as to set the maximal current allowed at the surface area indicated by the data item. Also provided is a method for iontophorectivally administering drug to or into a tissue, including determining a maximal allowed level of current density and preventing application of current density above the maximal allowed level.

Hebrew University of Jerusalem | Date: 2016-11-27

Articles-of-manufacturing comprising an object having a surface and at least a first layer of a first therapeutically active agent being deposited onto at least a continuous portion of the surface, wherein at least 50 weight percents of the first layer is the first therapeutically active agent in a crystalline form are disclosed. Methods utilizing such articles-of-manufacturing for treating medical conditions are also disclosed. Processes of preparing the articles-of-manufacturing by contacting a surface of the object with a solution containing the therapeutically active agent, without cooling the surface to a temperature below a temperature of the solution, are also disclosed.

Oneday Biotech And Pharma Ltd. and Hebrew University of Jerusalem | Date: 2017-01-25

The present invention relates to potent compounds having combined antioxidant, antiinflammatory, anti-radiation and metal chelating properties. Specifically, the present invention relates to short peptides having said properties, and to methods and uses of such short peptides in clinical and cosmetic applications.

Sonin E.B.,Hebrew University of Jerusalem
Advances in Physics | Year: 2010

The present review analyses and compares various types of dissipationless spin transport: (1) Superfluid transport, when the spin-current state is a metastable state (a local but not the absolute minimum in the parameter space). (2) Ballistic spin transport, when spin is transported without losses simply because the sources of dissipation are very weak. (3) Equilibrium spin currents, i.e. genuine persistent currents. (4) Spin currents in the spin Hall effect. Since superfluidity is frequently connected with Bose condensation, recent debates about magnon Bose condensation are also reviewed. For any type of spin currents simplest models were chosen for discussion in order to concentrate on concepts rather than the details of numerous models. The various hurdles on the way of using the concept of spin current (absence of the spin-conservation law, ambiguity of spin current definition, etc.) were analysed. The final conclusion is that the spin-current concept can be developed in a fully consistent manner, and is a useful language for the description of various phenomena in spin dynamics. © 2010 Taylor and Francis.

Atlas D.,Hebrew University of Jerusalem
Annual Review of Biochemistry | Year: 2013

Transmitter release is a fast Ca2+-dependent process triggered in response to membrane depolarization. It involves two major calcium-binding proteins, the voltage-gated calcium channel (VGCC) and the vesicular protein synaptotagmin (syt1). Ca2+ binding triggers transmitter release with a time response of conformational changes that are too fast to be accounted for by Ca2+ binding to syt1. In contrast, conformation-triggered release, which engages Ca2+ binding to VGCC, better accounts for the fast rate of the release process. Here, we summarize findings obtained from heterologous expression systems, neuroendocrine cells, and reconstituted systems, which reveal the molecular mechanism by which Ca2+ binding to VGCC triggers exocytosis prior to Ca2+ entry into the cell. This review highlights the molecular aspects of an intramembrane signaling mechanism in which a signal is propagated from the channel transmembrane (TM) domain to the TM domain of syntaxin 1A to trigger transmitter release. It discusses fundamental problems of triggering transmitter release by syt1 and suggests a classification of docked vesicles that might explain synchronous transmitter release, spontaneous release, and facilitation of transmitter release. © 2013 by Annual Reviews. All rights reserved.

Soreq H.,Hebrew University of Jerusalem
Trends in Neurosciences | Year: 2015

A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors, transporters, and synthesizing and degrading enzymes and regulators of their expression as contributors to cognition, metabolism, and immunity. Recent discoveries indicate that pre- and post-transcriptional ACh signaling controllers coordinate the identity, functioning, dynamics, and brain-to-body communication of cholinergic cells. Checks and balances including epigenetic mechanisms, alternative splicing, and miRNAs may all expand or limit the diversity of these cholinergic components by consistently performing genome-related surveillance. This regulatory network enables homeostatic maintenance of brain-to-body ACh signaling as well as reactions to nicotine, Alzheimer's disease anticholinesterase therapeutics, and agricultural pesticides. Here I review recent reports on the functional implications of these controllers of cholinergic signaling in and out of the brain. © 2015 Elsevier Ltd.

Ashenhurst J.A.,Hebrew University of Jerusalem
Chemical Society Reviews | Year: 2010

Biaryls constitute an important subunit found in medicinal agents, functional materials, and natural products. While the Suzuki reaction and related processes currently represent the method of choice for the construction of arene-arene bonds, the direct-coupling of two unfunctionalized arenes mediated by the addition of an oxidant represents a powerful alternative strategy for biaryl synthesis. This tutorial review describes recent progress in this rapidly developing field, focusing on intermolecular examples of selective arene oxidation strategies and metal-catalyzed oxidative cross-coupling via C-H activation. © 2010 The Royal Society of Chemistry.

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