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Jerusalem, Israel

The Hebrew University of Jerusalem is Israel's second-oldest university, after the Technion. The Hebrew University has three campuses in Jerusalem and one in Rehovot. The world's largest Jewish studies library is located on its Edmond J. Safra Givat Ram campus.The first Board of Governors included Albert Einstein, Sigmund Freud, Martin Buber, and Chaim Weizmann. Four of Israel's prime ministers are alumni of the Hebrew University. In the last decade, seven researchers and alumni of the University received the Nobel Prize and one was awarded the Fields Medal.According to the Academic Ranking of World Universities, the Hebrew University is the top university in Israel, overall the 59th-best university in the world, 16th in mathematics, 27th in computer science and 44th in business/economics.In 2013, the Center for World University Rankings ranked the Hebrew University 21st in the world and the top in Israel in its World University Rankings, while another survey ranked it as the 9th best university to work in, and the 2nd best outside of the United States. Wikipedia.


Atlas D.,Hebrew University of Jerusalem
Annual Review of Biochemistry | Year: 2013

Transmitter release is a fast Ca2+-dependent process triggered in response to membrane depolarization. It involves two major calcium-binding proteins, the voltage-gated calcium channel (VGCC) and the vesicular protein synaptotagmin (syt1). Ca2+ binding triggers transmitter release with a time response of conformational changes that are too fast to be accounted for by Ca2+ binding to syt1. In contrast, conformation-triggered release, which engages Ca2+ binding to VGCC, better accounts for the fast rate of the release process. Here, we summarize findings obtained from heterologous expression systems, neuroendocrine cells, and reconstituted systems, which reveal the molecular mechanism by which Ca2+ binding to VGCC triggers exocytosis prior to Ca2+ entry into the cell. This review highlights the molecular aspects of an intramembrane signaling mechanism in which a signal is propagated from the channel transmembrane (TM) domain to the TM domain of syntaxin 1A to trigger transmitter release. It discusses fundamental problems of triggering transmitter release by syt1 and suggests a classification of docked vesicles that might explain synchronous transmitter release, spontaneous release, and facilitation of transmitter release. © 2013 by Annual Reviews. All rights reserved. Source


Ashenhurst J.A.,Hebrew University of Jerusalem
Chemical Society Reviews | Year: 2010

Biaryls constitute an important subunit found in medicinal agents, functional materials, and natural products. While the Suzuki reaction and related processes currently represent the method of choice for the construction of arene-arene bonds, the direct-coupling of two unfunctionalized arenes mediated by the addition of an oxidant represents a powerful alternative strategy for biaryl synthesis. This tutorial review describes recent progress in this rapidly developing field, focusing on intermolecular examples of selective arene oxidation strategies and metal-catalyzed oxidative cross-coupling via C-H activation. © 2010 The Royal Society of Chemistry. Source


Patent
Fulcrum SP Ltd. and Hebrew University of Jerusalem | Date: 2015-06-07

SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.


Patent
Hebrew University of Jerusalem | Date: 2015-03-08

The present invention provides means and methods for simple and efficient introduction of foreign genetic material into the plant cell. Particularly, the present invention combines seed priming and virus-based DNA constructs for efficient introduction of heterologous DNA into plants.


Patent
Hebrew University of Jerusalem | Date: 2015-03-17

This invention relates to amino-alcohol analogues and uses thereof in the treatment of diseases and disorders such as cancer, neurodegenerative and metabolic diseases and genetic storage diseases.

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