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Hajjar I.,University of Southern California | Hart M.,Institute for Aging Research Hebrew Senior Life | Chen Y.-L.,University of Southern California | MacK W.,University of Southern California | And 4 more authors.
Journal of the American Geriatrics Society | Year: 2013

Objectives To compare the effects of three antihypertensive medications on cerebral hemodynamic and cognitive function in hypertensive individuals with executive dysfunction. Design Double-blind randomized clinical trial. Setting Community. Participants Fifty-three individuals aged 60 and older with hypertension and executive dysfunction. Intervention Lisinopril, candesartan, or hydrochlorothiazide for 1 year. Measurements Cerebral blood flow velocity (BFV; transcranial Doppler ultrasonography during rest, sitting, standing, hypercapnia, and hypocapnia), cognition, and blood pressure were measured at baseline and after 6 and 12 months. Linear mixed models were used to compare the three groups. Results Of the 53 participants, 47 had successful insonation (mean age 72; 70% white; 57% women). There was a tendency toward an increase in BFV in the candesartan group and a decrease in the lisinopril and hydrochlorothiazide groups (between-group P =.57) that was significant in those with low BFV at baseline (

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