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Zhangjiakou, China

Hebei North University is a multi-faculty university in Zhangjiakou, Hebei, China under the provincial government.Hebei North University is a provincially administrated multi-faculty university, which can grant Bachelors Academic Degree and Master Academic Degree. The University was founded in May 2003 after approval by the Ministry of Education. It comprises three former provincially administrated institutions of higher learning in Zhangjiakou: Zhangjiakou Medical College Zhangjiakou Teachers College Zhangjiakou Advanced Post-secondary Agriculture School It is the only multi-faculty university in the north of Hebei Province. Wikipedia.

Chang X.T.,Hebei North University
Sheng li ke xue jin zhan [Progress in physiology] | Year: 2011

TLRs belong to a family of pattern recognition receptors (PRRs) that recognize highly conserved microbial antigens termed pathogen associated molecular patterns (PAMPs). So far, ten TLRs have been identified in human genome. Each TLR senses a different set of microbial stimuli, and recruits various of adaptors and activates a series of distinct signaling cascades, and drives specific responses against the pathogens. TLRs bridged innate and adaptive immunity. The discoveries of Toll-like receptors guided the field of innate immunity to its present era of accelerated advancement. In this review, we will focus on the recent progresses of TLRs-mediated signaling. A better understanding of the immunological and molecular mechanisms mediated by TLRs will obviously facilitate the exploiting molecular targets of immunotherapy to control TLR-mediated diseases. Source

Wei Z.,Wuhan University | Wang R.,Hebei North University | Liu A.,Wuhan University
Mathematics and Computers in Simulation | Year: 2014

The paper presents a new four-dimensional hyperchaotic system developed by extension of the generalized diffusionless Lorenz equations. The model is shown to not be equivalent to any hyperchaotic system that the authors know of. In particular, the model does not display any equilibria, but can exhibit two-scroll hyperchaos as well as chaotic, quasiperiodic and periodic dynamics. For certain parameter values, coexisting attractors can be observed, e.g. hyperchaotic and periodic attractors. Investigation of the proposed system is performed through a combination of numerical simulation and mathematical analysis in order to obtain time plots, phase portraits, Lyapunov exponents, and Poincaré sections. © 2014 IMACS. Source

Dong X.-H.,Soochow University of China | Dong X.-H.,Hebei North University | Zhen X.-C.,Soochow University of China
CNS Neuroscience and Therapeutics | Year: 2015

Summary: Bipolar disorder (BD) is a chronic and severe mental disorder with recurrent episodes of mania and depression. In addition to neuronal alterations, accumulating evidences have revealed the importance of glial system in pathophysiology and phenotype of the illness. Postmortem studies have repeatedly demonstrated the alterations in glial cells and its functions in patients with BD. The activated microglia and inflammatory cytokines are proposed to be the potential biomarkers that may help to predict disease exacerbation in BD. On the other hand, anti-BD drugs have been shown to produce profound effects on glial activity, which not only contributes to the therapeutic efficacy, but may also provide a potential target for the drug development of BD. We will focus on the recent development of glial abnormalities and potential therapeutic benefits targeted to glial modulation in BD. © 2015 John Wiley & Sons Ltd. Source

Xue G.,Hebei North University
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2013

To investigate the levels of galectin-3 in the serum and surgical specimens from patients with malignant and benign thyroid lesions and explore their clinical significance. Serum samples were collected from 159 patients with thyroid neoplasms and 16 normal subjects for detection of galectin-3 level using ELISA. The expressions of galectin-3 protein and mRNA were also detected in the surgical specimens by immunohistochemistry and in situ hybridization. Galectin-3 protein and mRNA were expressed at a rate of 96.67% in 66 cases of papillary thyroid carcinoma, 83.33% in 6 cases of follicular thyroid carcinoma, 16.67% in 36 cases of papillary hyperplasia, and 11.74% in 51 cases of thyroid adenoma. The expression level of galectin-3 mRNA was slightly lower than but positively correlated with its protein expression. Patients with thyroid carcinoma had significantly higher serum concentration of galectin-3 than those with benign thyroid lesions (papillary hyperplasia and thyroid adenoma) and normal subjects (P<0.001). In patients with papillary thyroid carcinoma, galectin-3 positivity in the tumor tissue was associated with a significantly higher serum galectin-3 level in comparison with the negative cases (P<0.05). Detection of galectin-3 in both the serum and surgical specimens can improve the diagnosis rate of thyroid carcinoma. Source

Zhang L.L.,Hebei North University
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology | Year: 2011

To investigate the interference effects of lymph plasma on endotoxic shock and its mechanism. Sixty Wistar male rats were randomly divided into three groups: control group, model group and lymph plasma group. The endotoxic shock model of rats were duplicated by jugular intravenous injection with LPS (15 mg/kg), and after 15 minutes the normal lymph plasma was infused in lymph plasma group rats, which amount of lymph plasma was one fifteenth of whole blood volume. The effects of lymph plasma on the mean arterial pressure (MAP), microcirculation of mesentery near the ileum lower, the numbers of leukocytes adherent to the venular wall, the P-selectin and intercellular adhesion molecule-1 (ICAM-1) in plasma were observed. The normal lymph plasma might be prevent from progressive decreased of MAP, depress the pathologic diameter constriction of mesenteric microvessels, reduce leukocytes adherent to the venular wall, improve blood flow condition of microcirculation, and decrease the level of P-selectin and ICAM-1 in plasma (P < 0.05, P < 0.01). A little of normal lymph plasma plays a positive interference effect on microcirculatory dysfunction and hypotension with endotoxic shock induced by LPS challenge. Those mechanisms may be concerned with decreasing the production of cell adhesion molecules. Source

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