Hebei North University is a multi-faculty university in Zhangjiakou, Hebei, China under the provincial government.Hebei North University is a provincially administrated multi-faculty university, which can grant Bachelors Academic Degree and Master Academic Degree. The University was founded in May 2003 after approval by the Ministry of Education. It comprises three former provincially administrated institutions of higher learning in Zhangjiakou: Zhangjiakou Medical College Zhangjiakou Teachers College Zhangjiakou Advanced Post-secondary Agriculture School It is the only multi-faculty university in the north of Hebei Province. Wikipedia.
News Article | February 22, 2017
Findings may open new avenues to prevent transfer of health conditions from mothers to children Mothers contribute a lot of defining traits to their offspring, from eye color to toe length. But pregnant mothers with health complications, such as diabetes or hypertension, also can pass these symptoms to their children. What if we could prevent that? In a new study, researchers at the University of Iowa have shown they can reverse high blood pressure in offspring born to hypertensive rats. The results, though preliminary, may offer a promising avenue toward addressing "fetal programming," or the in utero transfer of certain health risks from mothers to children. The findings were published online this week in the journal Hypertension. In humans, gestational hypertension affects up to 15 percent of pregnancies. That percentage may rise because high blood pressure generally increases as we age, and American women are waiting longer to have children. Moreover, multiple studies have documented that offspring born to hypertensive mothers have higher blood pressure in childhood and are at higher risk of being hypertensive and contracting heart disease as adults. UI professor Alan Kim Johnson and his colleagues wanted to understand if gestational hypertension would affect blood pressure in baby rats and, if so, how the rats' brains might be involved. The group induced hypertension in mother rats during the perinatal period (three weeks before and after birth) and measured the blood pressure response in the offspring at 10 weeks, the rat equivalent of adulthood. The offspring were then given a hormone that elevates blood pressure to determine how they would respond. "What you see is enhanced, that is, a sensitized hypertensive response in animals where mothers had been hypertensive during pregnancy," says Johnson, F. Wendell Miller Distinguished Professor in the UI's Department of Psychological and Brain Sciences. The researchers then administered a drug called Captopril, which is commonly used to treat high blood pressure in human adults, to the rats born to hypertensive mothers and that had also been given the blood-pressure hormone. The rats that received Captopril from three to nine weeks of age were then tested for hypertension at 10 weeks and showed no signs of enhanced high blood pressure. "That means we can, in effect, deprogram them," Johnson says. Whether this would translate to humans is far from clear. But it opens a path for further study of the neural and chemical changes that occur in the brains of offspring born to hypertensive mothers--or mothers with other health issues--and how those conditions ultimately are passed on. Johnson's team has begun to document that transfer by tracking how the brain and central nervous system react to high blood pressure stressors. One, caused by a hormone called angiotensin II, appears to activate pathways from the brain that trigger a "sympathetic" response from the central nervous system. In other words, the central nervous system becomes more prone to elevate blood pressure when it senses the hormone. Researchers hypothesize the sympathetic response may become more conditioned, or overly responsive, in humans due to natural causes, such as with the children of mothers who had high blood pressure during their pregnancy. Johnson compares the process to a memory being made. In this case, the brain is establishing a "memory" of high blood pressure that's passed on to the offspring. But, importantly, researchers showed in the rat experiments that the memory can be altered, even erased. "We've changed the information that was laid down in the brain," Johnson says. "This study on rats sheds some light on how maternal health during pregnancy impacts long-term cardiovascular health of the offspring, says Christine Maric-Bilkan, program officer of the Division of Cardiovascular Sciences of the National Heart, Lung and Blood Institute (NHLBI). "These findings suggest a potential therapeutic strategy for prevention of elevated blood pressure in adults who were born to mothers that themselves had elevated blood pressure during pregnancy." Baojian Xue, in the UI Department of Psychological and Brain Sciences at the UI, is the first author. Contributing authors, also with the psychological and brain sciences department, are Fang Guo, Terry Beltz, and Robert Thunhorst. Haifeng Yin, a visiting professor now at Hebei North University in China, also contributed to the research. Johnson also is affiliated with the UI's pharmacology program and the Francois Abboud Cardiovascular Research Center. The National Heart, Lung and Blood Institute, part of the U.S. National Institutes of Health, funded the research through grants to Johnson.
You X.,China Agricultural University |
Wang S.,Hebei North University |
Liu F.,China Agricultural University |
Shi K.,China Agricultural University
Journal of Chromatography A | Year: 2013
A novel ultrasound-assisted surfactant-enhanced emulsification microextraction technique based on the solidification of a floating organic droplet followed by high performance liquid chromatography with diode array detection was developed for simultaneous determination of six fungicide residues in juices and red wine samples. The low-toxicity solvent, 1-dodecanol, was used as an extraction solvent. For its low density and proper melting point near room temperature, the extractant droplet was collected easily by solidifying it at a low temperature. The surfactant, Tween 80, was used as an emulsifier to enhance the dispersion of the water-immiscible extraction solvent into an aqueous phase, which hastened the mass-transfer of the analytes. Organic dispersive solvent typically required in common dispersive liquid-liquid microextraction methods was not used in the proposed method. Some parameters (e.g., the type and volume of extraction solvent, the type and concentration of surfactant, ultrasound extraction time, salt addition, and volume of samples) that affect the extraction efficiency were optimized. The proposed method showed a good linearity within the range of 5μgL-1-1000μgL-1, with the correlation coefficients (γ) higher than 0.9969. The limits of detection for the method ranged from 0.4μgL-1 to 1.4μgL-1. Further, this simple, practical, sensitive, and environmentally friendly method was successfully applied to determine the target fungicides in juice and red wine samples. The recoveries of the target fungicides in red wine and fruit juice samples were 79.5%-113.4%, with relative standard deviations that ranged from 0.4% to 12.3%. © 2013 Elsevier B.V.
Dong X.-H.,Soochow University of China |
Dong X.-H.,Hebei North University |
Zhen X.-C.,Soochow University of China
CNS Neuroscience and Therapeutics | Year: 2015
Summary: Bipolar disorder (BD) is a chronic and severe mental disorder with recurrent episodes of mania and depression. In addition to neuronal alterations, accumulating evidences have revealed the importance of glial system in pathophysiology and phenotype of the illness. Postmortem studies have repeatedly demonstrated the alterations in glial cells and its functions in patients with BD. The activated microglia and inflammatory cytokines are proposed to be the potential biomarkers that may help to predict disease exacerbation in BD. On the other hand, anti-BD drugs have been shown to produce profound effects on glial activity, which not only contributes to the therapeutic efficacy, but may also provide a potential target for the drug development of BD. We will focus on the recent development of glial abnormalities and potential therapeutic benefits targeted to glial modulation in BD. © 2015 John Wiley & Sons Ltd.
Chang X.T.,Hebei North University
Sheng li ke xue jin zhan [Progress in physiology] | Year: 2011
TLRs belong to a family of pattern recognition receptors (PRRs) that recognize highly conserved microbial antigens termed pathogen associated molecular patterns (PAMPs). So far, ten TLRs have been identified in human genome. Each TLR senses a different set of microbial stimuli, and recruits various of adaptors and activates a series of distinct signaling cascades, and drives specific responses against the pathogens. TLRs bridged innate and adaptive immunity. The discoveries of Toll-like receptors guided the field of innate immunity to its present era of accelerated advancement. In this review, we will focus on the recent progresses of TLRs-mediated signaling. A better understanding of the immunological and molecular mechanisms mediated by TLRs will obviously facilitate the exploiting molecular targets of immunotherapy to control TLR-mediated diseases.
Wei Z.,Wuhan University |
Wang R.,Hebei North University |
Liu A.,Wuhan University
Mathematics and Computers in Simulation | Year: 2014
The paper presents a new four-dimensional hyperchaotic system developed by extension of the generalized diffusionless Lorenz equations. The model is shown to not be equivalent to any hyperchaotic system that the authors know of. In particular, the model does not display any equilibria, but can exhibit two-scroll hyperchaos as well as chaotic, quasiperiodic and periodic dynamics. For certain parameter values, coexisting attractors can be observed, e.g. hyperchaotic and periodic attractors. Investigation of the proposed system is performed through a combination of numerical simulation and mathematical analysis in order to obtain time plots, phase portraits, Lyapunov exponents, and Poincaré sections. © 2014 IMACS.
Wei D.,Hebei North University |
Huang Z.,Hebei North University
Inflammation | Year: 2014
Triptolide is one of the main active components of Chinese herb Tripterygium wilfordii Hook F, which has been demonstrated to have anti-inflammatory properties. The aim of this study was to investigate the effects of triptolide on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and to clarify the possible mechanisms. Mice were administered intranasally with LPS to induce lung injury. Triptolide was administered intraperitoneally 1 h before LPS challenge. Triptolide-treated mice exhibited significantly reduced leukocyte, myeloperoxidase (MPO) activity, edema of the lung, as well as TNF-α, IL-1β, and IL-6 production in the bronchoalveolar lavage fluid compared with LPS-treated mice. Additionally, Western blot analysis showed that triptolide inhibited the phosphorylation of inhibitor-kappa B kinase-alpha (IκB-α), p65, nuclear factor kappa B (NF-κB), p38, extracellular receptor kinase (ERK), and Jun N-terminal kinase (JNK) and the expression of Toll-like receptor 4 (TLR4) caused by LPS. In conclusion, our results suggested that the promising anti-inflammatory mechanism of triptolide may be that triptolide activates peroxisome proliferation-activated receptor gamma (PPAR-γ), thereby attenuating an LPS-induced inflammatory response. Triptolide may be a promising potential therapeutic reagent for ALI treatment. © 2014 Springer Science+Business Media.
Zhang L.L.,Hebei North University
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology | Year: 2011
To investigate the interference effects of lymph plasma on endotoxic shock and its mechanism. Sixty Wistar male rats were randomly divided into three groups: control group, model group and lymph plasma group. The endotoxic shock model of rats were duplicated by jugular intravenous injection with LPS (15 mg/kg), and after 15 minutes the normal lymph plasma was infused in lymph plasma group rats, which amount of lymph plasma was one fifteenth of whole blood volume. The effects of lymph plasma on the mean arterial pressure (MAP), microcirculation of mesentery near the ileum lower, the numbers of leukocytes adherent to the venular wall, the P-selectin and intercellular adhesion molecule-1 (ICAM-1) in plasma were observed. The normal lymph plasma might be prevent from progressive decreased of MAP, depress the pathologic diameter constriction of mesenteric microvessels, reduce leukocytes adherent to the venular wall, improve blood flow condition of microcirculation, and decrease the level of P-selectin and ICAM-1 in plasma (P < 0.05, P < 0.01). A little of normal lymph plasma plays a positive interference effect on microcirculatory dysfunction and hypotension with endotoxic shock induced by LPS challenge. Those mechanisms may be concerned with decreasing the production of cell adhesion molecules.
Xue G.,Hebei North University
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2013
To investigate the levels of galectin-3 in the serum and surgical specimens from patients with malignant and benign thyroid lesions and explore their clinical significance. Serum samples were collected from 159 patients with thyroid neoplasms and 16 normal subjects for detection of galectin-3 level using ELISA. The expressions of galectin-3 protein and mRNA were also detected in the surgical specimens by immunohistochemistry and in situ hybridization. Galectin-3 protein and mRNA were expressed at a rate of 96.67% in 66 cases of papillary thyroid carcinoma, 83.33% in 6 cases of follicular thyroid carcinoma, 16.67% in 36 cases of papillary hyperplasia, and 11.74% in 51 cases of thyroid adenoma. The expression level of galectin-3 mRNA was slightly lower than but positively correlated with its protein expression. Patients with thyroid carcinoma had significantly higher serum concentration of galectin-3 than those with benign thyroid lesions (papillary hyperplasia and thyroid adenoma) and normal subjects (P<0.001). In patients with papillary thyroid carcinoma, galectin-3 positivity in the tumor tissue was associated with a significantly higher serum galectin-3 level in comparison with the negative cases (P<0.05). Detection of galectin-3 in both the serum and surgical specimens can improve the diagnosis rate of thyroid carcinoma.
Li S.G.,Hebei North University
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2013
To investigate the effect of andrographolide (AD) on proliferation, cell cycle and apoptosis of human gastric cells line BGC-823. MTT assay, flow cytometry and Annexin-V/PI double-staining flow cytometry assay were used to evaluate the effect of AD on proliferation, cell cycle and apoptosis of BGC-823 cells respectively. Optical microscope and transmission electron microscopy were used to observe the cell morphological changes. A time- and concentration-dependent proliferative inhibition effect of AD was demonstrated in BGC-823 cells. AD concentration lower than 7.5 mg/L possessed weak inhibitory effect,while concentration between 15.0-60.0 mg/L possessed higher inhibitory effect. The concentration higher than 60.0 mg/L had no significant increase of inhibitory effect. IC50 of AD at 24, 48 and 72 h was (35.3±4.3), (25.5±3.5) and (18.2±2.7) mg/L respectively. Compared with the negative control group, the number of G0/G1 phase cells increased significantly (P<0.05), while the number of S and G2/M phase cells decreased after incubation with AD for 48 h, and the alteration was in a concentration-dependent manner. AD arrested BGC-823 cells at the G0/G1 phase of the cell cycle. After incubation with 7.5, 10.0 and 15.0 mg/L AD for 24 h, the early apoptotic rates of BGC-823 cells were (19.3±4.7)%, (29.4±4.1)% and (52.7±6.7)% respectively, and the late apoptotic rates were (10.8±1.8)%, (10.9±4.7)% and (14.7±4.8)% respectively. Both the early apoptotic rates and the late apoptotic rates increased significantly compared to the control group (all P<0.05),and the alteration was in a concentration-dependent manner. Andrographolide can inhibit BGC-823 cells proliferation, arrest BGC-823 cells in G0/G1 phase and induce apoptosis, and may be a potential traditional Chinese medicine with anti-cancer effect.
News Article | November 21, 2016
Hebei North University is a government administrated multi-faculty university, which offers Bachelor's degree programs and Master's degree programs. The University was founded in September 2003 after approval from the Ministry of Education.