Zhangjiakou, China
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Song X.,Zhejiang Agriculture And forestry University | Peng C.,University of Quebec at Montréal | Peng C.,Northwest Agriculture and Forestry University | Zhao Z.,University of Quebec at Montréal | And 5 more authors.
Atmospheric Environment | Year: 2014

We collected 139 estimates of the annual forest soil CO2 flux and 173 estimates of the Q10 value (the temperature sensitivity) assembled from 90 published studies across Chinese forest ecosystems. We analyzed the annual soil respiration (Rs) rates and the temperature sensitivities of seven forest ecosystems, including evergreen broadleaf forests (EBF), deciduous broadleaf forests (DBF), broadleaf and needleleaf mixed forests (BNMF), evergreen needleleaf forests (ENF), deciduous needleleaf forests (DNF), bamboo forests (BF) and shrubs (SF). The results showed that the mean annual Rs rate was 33.65t CO2ha-1year-1 across Chinese forest ecosystems. Rs rates were significantly different (P<0.001) among the seven forest types, and were significantly and positively influenced by mean annual temperature (MAT), mean annual precipitation (MAP), and actual evapotranspiration (AET); but negatively affected by latitude and elevation. The mean Q10 value of 1.28 was lower than the world average (1.4-2.0). The Q10 values derived from the soil temperature at a depth of 5cm varied among forest ecosystems by an average of 2.46 and significantly decreased with the MAT but increased with elevation and latitude. Moreover, our results suggested that an artificial neural network (ANN) model can effectively predict Rs across Chinese forest ecosystems. This study contributes to better understanding of Rs across Chinese forest ecosystems and their possible responses to global warming. © 2014 Elsevier Ltd.


Li Y.,Hebei North College | Liu X.-X.,Airforce General Hospital of PLA | Wang W.-E.,Airforce General Hospital of PLA | Wang Y.,Airforce General Hospital of PLA | Gao H.,Airforce General Hospital of PLA
Medical Journal of Chinese People's Liberation Army | Year: 2013

Objective To evaluate the efficacy and safety of polysomnography-manual continuous positive airway pressure titration (PSG-CPAP), polysomnography-automatic positive airway pressure titration (PSG-APAP), or automatic positive airway pressure titration (APAP) in patients with moderate or severe simple obstructive sleep apnea syndrome (OSAS). Methods Twenty patients with moderate or severe OSAS sequentially underwent PSG-CPAP, PSG-APAP and APAP titration 3 days apart, and then 3 primary efficacy indicators (titration pressure, remaining respiratory event and state of sleep), and safety indicators (compression injury of face skin, the subjective evaluation on degree of comfort or any complaint during titration) were compared. Results The results of efficacy indicators revealed that all PSG-APAP, APAP and PSG-CPAP were effective. Compared with the optimal pressure of PSG-CPAP titration, PSG-APAP and APAP pressures were 3.05 and 2.55cmH2O higher, respectively, in 90% of occasion (P<0.01). However, there was no statistically significant difference between APAP and PSG-APAP titration (P>0.05). There was no statistically significant difference between the optimal pressure of PSG-CPAP and the mean pressures of PSG-APAP and APAP (P>0.05). There was no statistically significant difference between the 3 titration methods on residue apnea/hypopnea index (AHI, P>0.05). The oxygen desaturation index (ODI) decreased significantly after titration treatment (P<0.01), but no statistically significant difference was found between PSG-CPAP and PSG-APAP titration (P>0.05). Both PSG-CPAP and PSG-APAP titrations showed the same effects in improving ODI. Compared with basic PSG, no obvious improvement was found in sleep efficiency (SE) after PSG-CPAP and PSG-APAP titration (P>0.05), however, the arousal index (ArI) decreased obviously (P<0.01), the percentage of sleep time spent during N1 phase (N1%) and N2 phase (N2%) decreased significantly (P<0.05), but prolonged in N3 phase (N3%) and R phase (R%) significantly (P<0.01). Both PSG-CPAP and PSG-APAP improved the state of sleep, but with no significant difference (P>0.05). The results of safety indicators showed that no face skin compression injury or severe adverse event related to the titration was found in all the patients during the study. The main complaints of the patients were sleep disturbance, dryness of eyes or mouth, headache, breath holding and abdominal distention. Conclusion Both PSG-APAP and APAP titration are effective in treatment with moderate or severe simple OSAS, the measured mean pressure may be used to define the optimal therapeutic pressure of CPAP.


Lu Y.,Hebei North College | Liu B.,Hebei North College
Chinese Journal of Cancer Prevention and Treatment | Year: 2012

OBJECTIVE: To investigate the expression of metastasis-associated gene 2(MTA2) in esophageal squamous cell carcinoma(ESCC), and relationship between expression and lymph node metastasis of ESCC. METHODS: Expressions of MTA2 was detected by immunohistochemical staining (SP) and flow cytometry (FCM) in tissues from 102 patients with ESCC and 12 normal esophageal mucosa. Analysis was performed in relationship with lymph node metastasis. RESULTS: The expression rate of MTA2 in ESCC was 68.6% (70/102). MTA2 was negative expressed in normal esophageal mucosa. The expression rate of MTA2 in esophageal esophageal with or without metastasis of lymph nodes were 68.2% (15/22) and 27.1% (13/48), and there was a significant deference (P=0.003). The expression of MTA2 was related to the lymphatic metastasis of ESCC, and its expression level was higher in patients with lymphatic metastasis. The protein relative level detected by FCM: the protein content of MTA2 were 252.11±30.22 in positive lymph node metastasis and 161.42±22.89 in negative group, There was a significant deference (t=15.11, P=0.000). CONCLUSION: The expression of MTA2 in ESCC is related with lymph node metastasis and MTA2 may act as a new symbol and target in the treatment of ESCC.


Li H.-J.,Hebei North College | Wang J.-M.,Hebei North College | Tian Y.-T.,Hebei North College | Bai M.-L.,Hebei North College | And 2 more authors.
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

OBJECTIVE: To study the effect of matrine on Fas, VEGF, and activities of telomerase of MCF-7 cells.METHODS: In vitro cultured human breast cancer MCF-7 cells were randomly divided into the experimental group and the control group. The matrine solution was added in cells of the experimental group. Equal volume of culture medium was added in cells of the control group or the negative control group. Zedoary Turmeric Oil, the telomerase inhibitor was added in cells of the positive control group. Morphological changes were observed under an inverted microscope. The telomerase activity was detected by TRAP-ELISA. Expressions of Fas and VEGF protein were detected by immunocytochemical assay.RESULTS: Matrine obviously inhibited the growth and induced apoptosis of breast cancer cells. MCF-7 cells were treated by matrine of different concentrations at 24, 48, and 72 h, the telomerase activity gradually decreased along with increased matrine concentration and prolonged action time, showing dose-effect and time-effect positive relations. Matrine could up-regulate Fas protein expression and downregulate VEGF protein expression of MCF-7 cells.CONCLUSION: Matrine showed obvious effect in inhibiting the growth of MCF-7 cells and promoting the apoptosis, which might be achieved by up-regulating the expression of Fas protein, inhibiting telomerase activity induced apoptosis of breast cancer cells, down-regulating the expression of VEGF protein, and inhibiting the tumor vascular formation.


Song X.,Zhejiang Agriculture And forestry University | Jiang H.,Zhejiang Agriculture And forestry University | Zhang Z.,Hebei North College | Zhou G.,Zhejiang Agriculture And forestry University | And 2 more authors.
Soil Biology and Biochemistry | Year: 2014

Being two important agents of global environmental change, elevated ultraviolet-B (UV-B) radiation derived from anthropogenic driven ozone depletion and enhanced nitrogen (N) deposition may strongly affect litter decomposition, a crucial factor in biogeochemical cycling. However, the interactive effects of both agents together on litter decomposition are still unclear even though each has been well-documented independently. We conducted a field-based experiment in subtropical China to investigate the combined effects UV-B radiation and N deposition on the decomposition of Moso bamboo (Phyllostachys pubescens) leaf litter over a 20 months period. It was found that the combined effect significantly accelerated litter decomposition, C loss, and lignin degradation as well as facilitating phosphorous (P) release, although it had no measurable effect on N release. Moreover, the interactive effects of both agents together far exceeded the effects of each separately. Results indicated that the positive combined effect of UV-B radiation and N deposition on litter decomposition and C loss could potentially impact Moso bamboo forest ecosystem C cycling. These findings provide a new perspective to further understand the interactive effects of global environmental changes on terrestrial ecosystem processes. © 2013 Elsevier Ltd.


Zhang H.-L.,Zhejiang Agriculture And forestry University | Song X.-Z.,Zhejiang Agriculture And forestry University | Zhang Z.-T.,Hebei North College | Jiang H.,Zhejiang Agriculture And forestry University | And 2 more authors.
Chinese Journal of Applied Ecology | Year: 2011

A litterbag experiment was conducted to study the decomposition of Cunninghamia lan-ceolata leaf litter under ambient and reduced UV-B radiation (22.1% below ambient). Comparing with ambient treatment, the reduced treatment decreased the decomposition rate of C. lanceolata leaf litter by 69.6% (P<0.001), making the relative contents of nitrogen (N), phosphorus (P), and lignin in the litter increased by 150%, 83.3%, and 13.8%, respectively, and the release of potassium (K) and carbon (C) slowed down. In the process of litter decomposition, photo-degradation of lignin didn't play crucial role. The results suggested that UV-B radiation could accelerate the decomposition rate of C. lanceolata leaf litter, promote the release of N, P, K, and C from it, and increase the nutrients turnover rate in litter layer as well as the carbon flux on the ground, giving potential effects on the function of C. lanceolata forest as a carbon source or sink in humid subtropical China.


Bai M.L.,Hebei North College
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

To observe the effects of deguelin on the apoptosis and proliferation of human esophageal cancer cell Ec-109, and to explore its possible mechanisms. Human esophageal cancer cells Ec-109 were in vitro cultured. They were divided into the blank control group, and 5, 10, 20, and 40 nmol/L deguelin groups. The inhibition on the proliferation was detected at 24, 48, and 72 h using CCK-8 assay. The early apoptosis rate at 24 h was detected by flow cytometry. The expressions of apoptosis-related proteins Bcl-2 and Bax were detected at 24 and 48 h respectively. Compared with the blank control group at the same point, the growth inhibition rate in all deguelin groups increased at 24, 48, and 72 h, showing statistical difference (P <0.05). The early apoptosis rate was 4.37% +/- 0.35%, 6.71% +/-0.14%, 15.62% +/- 0.21%, and 19.78% +/- 0.15% in 5, 10, 20, and 40 nmol/L deguelin groups, respectively, showing statistical difference when compared with that of the blank control group (1.10% +/- 0.08%, P < 0.05). Compared with the blank control group, Bcl-2 protein expression obviously decreased, and Bax protein expression obviously increased in 10, 20, and 40 nmol/L deguelin groups, showing statistical difference (P <0.05). The aforesaid indices were in time- and dose-dependent manners. Deguelin showed obvious effects on inhibiting the proliferation of Ec-109 cells and promoting their apoptosis, which was correlated with up-regulating Bax protein expression and down-regulating Bcl-2 protein expression.


Li X.-J.,Hebei North College | Zhai L.-P.,First Affiliated Hospital of Hebei North College | Liu J.-C.,First Affiliated Hospital of Hebei North College
Chinese Journal of Cancer Prevention and Treatment | Year: 2013

OBJECTIVE: To study the expression of Oct4 in esophageal squamous cell carcinoma (ESCC) and analyze the relationship between the expression of Oct4 and clinical prognosis. METHODS: Immunohistochemistry staining SP was used to detect the expression level of Oct4 in 58 cases of ESCC and 21 normal mucous memebrane. Subsequently the relationship between postoperative pathological features with the expression of Oct4 was analyzed. These 58 patients were followed for 8 years at least. Kaplan-Meier method and Log-Rank test were employed to explore the correlation between Oct4 expression and survival, and Cox regression analysis was performed to evaluate the connection between expression of Oct4 and prognosis. RESULTS: The positive expression rate of Oct4 in ESCC was 60.3%(35/58), obviously higher than that of normal esophageal (19.0%, 4/21, χ2=10.519, P=0.001). There was no significant difference in the expression of Oct4 among patients with age (χ2=0.023, P=0.879), gender (χ2=0.043, P=0.836), lymph mode metastasis (χ2=0.551, P=0.458), invasion of adventitia (χ2=0.364, P=0.546) and UICC stage (χ2=1.038, P=0.308). The expression of Oct4 in low differentiation group was higher than that in well or moderate differentiated(χ2=6.061, P=0.014). Oct4 expression was higher in deaths than that in survival cases (χ2=7.958, P=0.005). Patients with higher expression of Oct4 had significantly shorter survival time (χ2=7.703, P=0.006). The expression of Oct4 was obviously correlated with the prognosis of ESCC (RR=2.243, P=0.001). CONCLUSION: The expression of Oct4 is related to the differentiation and survival time of patients with ESCC, and it is an independent prognostic factor for ESCC.


Huang J.,Hebei North College | Wu J.-F.,Hebei North College | Zhang J.,Hebei North College | Zhang W.-J.,Hebei North College | And 2 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2013

OBJECTIVE: To investigate the expression of VEGF-C/D, VEGFR-3 and D2-40 in papillary thyroid carcinoma (PTC) and the relationship with lymph node metastasis. METHODS: The expression of VEGF-C/D, VEGFR-3 and D2-40 in 68 cases of papillary thyroid carcinoma (PTC) and 30 cases of thyroid adenoma (TA) were detected by immunohistochemical staining. The difference of VEGF-C/D and VEGFR-3 in PTC and TA, PTC with lymph node metastasis and without metastasis was compared. The lymphatic vessel density(LVD) of VEGFR-3 and D2-40 was counted respectively. RESULTS: The positive rate of VEGF-C, VEGF-D, VEGFR-3 and D2-40 in PTC group was higher than those in TA group (85.29% vs 16.67%, χ2=47.70, P<0.001), (77.94% vs 13.33%, χ2=35.71, P<0.001), (83.82% vs 13.33%, χ2=43.56, P<0.001), (79.41% vs 10.00%, χ2=35.19, P<0.001). The positive rate of VEGF-C and VEGFR-3 in PTC with lymph node metastasis was higher than that without lymph node metastasis, and there was a positive relationship between the two indexs and lymph node metastasis (100.00% vs 77.55%, χ2=3.876, P=0.034, r=0.259, P=0.024, 100.00% vs 77.55%; χ2=5.014, P=0.025, r=0.274, P=0.024). In group PTC, D2-40 and VEGFR-3 positive LVD were significantly higher than those of TA group(3.4±0.4 vs 0.5±0.4, t=12.526, P<0.001; 4.1±0.7 vs 0.7±0.6, t=13.163, P<0.001), and PTC with lymph node metastasis group was significantly higher than those without metastasis (5.6±3.7 vs 2.7±1.5, t'=2.758, P=0.009; 6.9±3.5 vs 3.3±0.9, t'=3.224, P=0.002); Peri-carcinoma VEGFR-3 positive LVD (12.6±4.1) was higher than that of D2-40 (7.9±4.3), t=2.106, P=0.04. CONCLUSIONS: The high expression of VEGF-C/D, VEGFR-3 and D2-40 in PTC are closely associated with lymph node metastasis. VEGF-C, VEGFR-3, D2-40 combined detection may be used as an important index in predicting lymph node metastasis.


PubMed | Hebei North College
Type: Journal Article | Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine | Year: 2013

To study the effect of matrine on Fas, VEGF, and activities of telomerase of MCF-7 cells.In vitro cultured human breast cancer MCF-7 cells were randomly divided into the experimental group and the control group. The matrine solution was added in cells of the experimental group. Equal volume of culture medium was added in cells of the control group or the negative control group. Zedoary Turmeric Oil, the telomerase inhibitor was added in cells of the positive control group. Morphological changes were observed under an inverted microscope. The telomerase activity was detected by TRAP-ELISA. Expressions of Fas and VEGF protein were detected by immunocytochemical assay.Matrine obviously inhibited the growth and induced apoptosis of breast cancer cells. MCF-7 cells were treated by matrine of different concentrations at 24, 48, and 72 h, the telomerase activity gradually decreased along with increased matrine concentration and prolonged action time, showing dose-effect and time-effect positive relations. Matrine could up-regulate Fas protein expression and downregulate VEGF protein expression of MCF-7 cells.Matrine showed obvious effect in inhibiting the growth of MCF-7 cells and promoting the apoptosis, which might be achieved by up-regulating the expression of Fas protein, inhibiting telomerase activity induced apoptosis of breast cancer cells, down-regulating the expression of VEGF protein, and inhibiting the tumor vascular formation.

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