Li Q.-X.,Hebei Peoples General Hospital |
Xing Y.-J.,Hebei Peoples General Hospital |
Yan X.-L.,Hebei Peoples General Hospital |
Yan C.-Y.,Hebei Peoples General Hospital |
And 3 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2013
OBJECTIVE: To investigate the expression of Survivin and AIB-1 protein and their relationship with clinical features of invasive ductal carcinoma of breast(IDC). METHODS: Expression of Survivin and AIB-1 was examined by immunohistochemical method in 81 cases of IDC. RESULTS: The positive rate of Survivin and AIB-1 in IDC tissues were 77.8%(63/81) and 80.2%(65/81), respectively. The expression of Survivin and AIB-1 were positively related with the lymph node metastasis(χ2=7.475, P=0.006; χ2=5.806, P=0.016), but both of them were not related with age(χ2=1.714, P=0.19; χ2=3.844, P=0.05). There was a significant difference in the positive rates of Survivin expression in different tumor size, histological grade and clinical stage(χ2=5.495, P=0.019; χ2=9.691, P=0.008; χ2=10.223, P=0.001). The expression of AIB-1 had no significant correlation with those clinicopathological features. The positive corelation was observed between the expressions of Survivin and AIB-1(r=0.257, P=20.021). CONCLUSIONS: The expressions of Survivin and AIB-1 are corelated with breast cancer invasion and metastasis. Combined detection of Survivin and AIB-1 can be valuable for evaluating the prognosis of IDC.