Entity

Time filter

Source Type


Ma F.-P.,Hebei Normal University | Cheng G.-T.,Hebei Chemical and Pharmaceutical Vocational Technology College | He Z.-G.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Australian Journal of Chemistry | Year: 2012

A general, efficient and green method for the synthesis of quinoline derivatives via the Friedländer heteroannulation reaction of 2-aminoaryl ketones and α-methylene ketones has been developed, employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as an inexpensive, non-toxic, easily biodegradable reaction medium. The melt acts as both the reaction medium and catalyst, furnishing quinolines in high to excellent yields. © 2012 CSIRO. Source


Hao Y.X.,Hebei Chemical and Pharmaceutical Vocational Technology College
Applied Mechanics and Materials | Year: 2014

Taking 7-APCA as raw materials, in a suitable solvent system, to get 7-APCA alkali solution with the alkali reaction. The paper takes p-hydroxyphenyl glycine dane salt as raw material, to made the corresponding reagent in phthalic anhydride. Forming DMF salt of cefprozil by reaction of 7-APCA alkaline solution and the mixed anhydride. The transformation of methanol, water, and water purification to get cefprozil monohydrate. The total yield was 63%. The chemical structure of cefprozil were confirmed by IR, 1h-nmr. Product quality in line with national pharmacopoeia requirements. © (2014) Trans Tech Publications, Switzerland. Source


Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Wang P.,Hebei Normal University | Ma F.-P.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Journal of Molecular Liquids | Year: 2014

l-(+)-Tartaric acid-choline chloride based deep eutectic solvent has been found to be an effective promoted medium for Clauson-Kaas reaction of aromatic amines and 2,5-dimethoxytetrahydrofuran. Structurally diverse N-substituted pyrroles were obtained in high to excellent yields under mild conditions. The deep eutectic solvent is inexpensive, non-toxic, reusable and biodegradable. © 2014 Elsevier B.V. Source


Sun Y.M.,Hebei Chemical and Pharmaceutical Vocational Technology College
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2010

To observe the effect of intracerebroventricular injection of rAAV-HIF-1α on hippocampal neuronal apoptosis in a rat model of Alzheimer disease (AD). Thirty-two male SD rats (250-300 g) were randomized into 4 groups (n=8), including the normal control group without any treatment, AD model group with right intracerebroventricular injection of 2 μl Aβ25-35 (10 mg/m1), sham-operated group with right intracerebroventricular injection of 2 μl normal saline, and AD+ rAAV-HIF-1α group with right intracerebroventricular injection of 10 μl rAAV-HIF-1a (1×1012 v.g./m1) one week after Aβ25-35 injection. The rats were sacrificed to detect the expression of HIF-1α and apoptosis of hippocampal neurons 5 weeks after Aβ25-35 or saline injection. Western blotting showed that the expression of HIF-1α was significantly higher in AD+rAAV-HIF-1α group (451.59±34.39) than in normal control group (229.05±41.28) and sham-operated group (216.29±37.08) (P<0.05) without significant difference between the latter two groups. The apoptotic ratio of the hippocampal neurons was significantly higher in AD model group ([19.49±2.59]%) than in normal control group ([5.41±0.75]%) and sham-operated group ([5.28±0.66]%) in (P<0.05), and intracerebroventricular injection of rAAV-HIF-1α resulted in a significant reduction of the apoptotic ratio in the AD rats ([12.07±2.06]%) (P<0.05). Intracerebroventricular injection of rAAV-HIF-1α can inhibit hippocampal neuronal apoptosis in the rat model of AD. Source


Guo R.-Y.,Hebei Normal University | Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Wang G.-D.,Hebei Normal University | Mo L.-P.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Tetrahedron | Year: 2013

A general, efficient, and green method for one-pot synthesis of functionalized spirooxindoles through three-component condensation reaction of isatins, cyclohexane-1,3-diones, and barbituric acids is described employing gluconic acid aqueous solution (GAAS) as a novel reaction medium and catalyst. The reaction medium could be recycled and reused several times without significant loss of its efficiency. © 2013 Elsevier Ltd. All rights reserved. Source

Discover hidden collaborations