Hebei Chemical and Pharmaceutical Vocational Technology College

Hebei, China

Hebei Chemical and Pharmaceutical Vocational Technology College

Hebei, China
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Shi L.-J.,Hebei Medical University | Shi L.,Hebei Chemical and Pharmaceutical Vocational Technology College | Song G.-Y.,Hebei General Hospital | Zhang H.-F.,Hebei Medical University | And 3 more authors.
European Journal of Pharmacology | Year: 2013

The aim of this study was to examine the therapeutic effect of oxymatrine, a monomer isolated from the medicinal plant Sophora flavescens Ait, on the hepatic lipid metabolism in non-alcoholic fatty liver (NAFLD) rats and to explore the potential mechanism. Rats were fed with high fructose diet for 8 weeks to establish the NAFLD model, then were given oxymatrine treatment (40, 80, and 160 mg/kg, respectively) for another 8 weeks. Body weight gain, liver index, serum and liver lipids, and histopathological evaluation were measured. Enzymatic activity and gene expression of the key enzymes involved in the lipogenesis and fatty acid oxidation were assayed. The results showed that oxymatrine treatment reduced body weight gain, liver weight, liver index, dyslipidemia, and liver triglyceride level in a dose dependant manner. Importantly, the histopathological examination of liver confirmed that oxymatrine could decrease the liver lipid accumulation. The treatment also decreased the fatty acid synthase (FAS) enzymatic activity and increased the carnitine palmitoyltransferase 1A (CPT1A) enzymatic activity. Besides, oxymatrine treatment decreased the mRNA expression of sterol regulatory element binding transcription factor 1(Srebf1), fatty acid synthase (Fasn), and acetyl CoA carboxylase (Acc), and increased the mRNA expression of peroxisome proliferator activated receptor alpha (Pparα), carnitine palmitoyltransferase 1A (Cpt1a), and acyl CoA oxidase (Acox1) in high fructose diet induced NAFLD rats. These results suggested that the therapeutic effect of oxymatrine on the hepatic steatosis in high fructose diet induced fatty liver rats is partly due to down-regulating Srebf1 and up-regulating Pparα mediated metabolic pathways simultaneously. © 2013 Elsevier B.V. All rights reserved.


Zhou Y.,Nantong University | Zhai X.,Nantong University | Yan K.,Nantong University | Fan J.,Hebei Chemical and Pharmaceutical Vocational Technology College | And 3 more authors.
British Journal of Pharmacology | Year: 2013

Background and Purpose Liver fibrosis is commonly associated with obesity and most obese patients develop hyperleptinaemia. The adipocytokine leptin has a unique role in the development of liver fibrosis. Activation of hepatic stellate cells (HSCs) is a key step in hepatic fibrogenesis and sterol regulatory element-binding protein-1c (SREBP-1c) can inhibit HSC activation. We have shown that leptin strongly inhibits SREBP-1c expression in rat HSCs. Hence, we aimed to clarify whether the β-catenin pathway, the crucial negative regulator of adipocyte differentiation, mediates the effects of leptin on SREBP-1c expression in HSCs and in mouse liver fibrosis. Experimental Approach HSCs were prepared from rats and mice. Gene expressions were analysed by real-time PCR, Western blot analysis, immunostaining and transient transfection assays. Key Results Leptin increased β-catenin protein but not mRNA levels in cultured HSCs. Leptin induced phosphorylation of glycogen synthase kinase-3β at Ser9 and subsequent stabilization of β-catenin protein was mediated, at least in part, by ERK and p38 MAPK pathways. The leptin-induced β-catenin pathway reduced SREBP-1c expression and activity but did not affect protein levels of key regulators controlling SREBP-1c activity, and was not involved in leptin inhibition of liver X receptor α. In a mouse model of liver injury, the β-catenin pathway was shown to be involved in leptin-induced liver fibrosis. Conclusions and Implications The β-catenin pathway contributes to leptin regulation of SREBP-1c expression in HSCs and leptin-induced liver fibrosis in mice. These results have potential implications for clarifying the mechanisms of liver fibrogenesis associated with elevated leptin levels. © 2013 The Authors. British Journal of Pharmacology © 2013 The British Pharmacological Society.


Hao Y.X.,Hebei Chemical and Pharmaceutical Vocational Technology College
Applied Mechanics and Materials | Year: 2014

Taking 7-APCA as raw materials, in a suitable solvent system, to get 7-APCA alkali solution with the alkali reaction. The paper takes p-hydroxyphenyl glycine dane salt as raw material, to made the corresponding reagent in phthalic anhydride. Forming DMF salt of cefprozil by reaction of 7-APCA alkaline solution and the mixed anhydride. The transformation of methanol, water, and water purification to get cefprozil monohydrate. The total yield was 63%. The chemical structure of cefprozil were confirmed by IR, 1h-nmr. Product quality in line with national pharmacopoeia requirements. © (2014) Trans Tech Publications, Switzerland.


Sun Y.M.,Hebei Chemical and Pharmaceutical Vocational Technology College
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2010

To observe the effect of intracerebroventricular injection of rAAV-HIF-1α on hippocampal neuronal apoptosis in a rat model of Alzheimer disease (AD). Thirty-two male SD rats (250-300 g) were randomized into 4 groups (n=8), including the normal control group without any treatment, AD model group with right intracerebroventricular injection of 2 μl Aβ25-35 (10 mg/m1), sham-operated group with right intracerebroventricular injection of 2 μl normal saline, and AD+ rAAV-HIF-1α group with right intracerebroventricular injection of 10 μl rAAV-HIF-1a (1×1012 v.g./m1) one week after Aβ25-35 injection. The rats were sacrificed to detect the expression of HIF-1α and apoptosis of hippocampal neurons 5 weeks after Aβ25-35 or saline injection. Western blotting showed that the expression of HIF-1α was significantly higher in AD+rAAV-HIF-1α group (451.59±34.39) than in normal control group (229.05±41.28) and sham-operated group (216.29±37.08) (P<0.05) without significant difference between the latter two groups. The apoptotic ratio of the hippocampal neurons was significantly higher in AD model group ([19.49±2.59]%) than in normal control group ([5.41±0.75]%) and sham-operated group ([5.28±0.66]%) in (P<0.05), and intracerebroventricular injection of rAAV-HIF-1α resulted in a significant reduction of the apoptotic ratio in the AD rats ([12.07±2.06]%) (P<0.05). Intracerebroventricular injection of rAAV-HIF-1α can inhibit hippocampal neuronal apoptosis in the rat model of AD.


Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Wang P.,Hebei Normal University | Ma F.-P.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Journal of Molecular Liquids | Year: 2014

l-(+)-Tartaric acid-choline chloride based deep eutectic solvent has been found to be an effective promoted medium for Clauson-Kaas reaction of aromatic amines and 2,5-dimethoxytetrahydrofuran. Structurally diverse N-substituted pyrroles were obtained in high to excellent yields under mild conditions. The deep eutectic solvent is inexpensive, non-toxic, reusable and biodegradable. © 2014 Elsevier B.V.


Tian A.,Bohai University | Lin X.,Bohai University | Sun N.,Hebei Chemical and Pharmaceutical Vocational Technology College | Ying J.,Bohai University | And 3 more authors.
Inorganic Chemistry Communications | Year: 2014

A new Keggin-type polyoxometalate (POM)-based compound, [Ag 9(ptz)5][PMoVI 11MoVO 40]·H2O (1) (ptzH = 5-phenyl-1H-tetrazole), was synthesized under hydrothermal conditions. Compound 1 exhibits a 2D layer containing AgI ribbons and hexa-nuclear AgI circles, which are further linked by AgI atoms and [PMoVI 11MoVO40]4 - anions to construct a 3D framework. The electrochemical properties of compound 1 have been investigated. © 2013 Elsevier B.V. All rights reserved.


Ma F.-P.,Hebei Normal University | Cheng G.-T.,Hebei Chemical and Pharmaceutical Vocational Technology College | He Z.-G.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Australian Journal of Chemistry | Year: 2012

A general, efficient and green method for the synthesis of quinoline derivatives via the Friedländer heteroannulation reaction of 2-aminoaryl ketones and α-methylene ketones has been developed, employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as an inexpensive, non-toxic, easily biodegradable reaction medium. The melt acts as both the reaction medium and catalyst, furnishing quinolines in high to excellent yields. © 2012 CSIRO.


Guo R.-Y.,Hebei Normal University | Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Wang G.-D.,Hebei Normal University | Mo L.-P.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Tetrahedron | Year: 2013

A general, efficient, and green method for one-pot synthesis of functionalized spirooxindoles through three-component condensation reaction of isatins, cyclohexane-1,3-diones, and barbituric acids is described employing gluconic acid aqueous solution (GAAS) as a novel reaction medium and catalyst. The reaction medium could be recycled and reused several times without significant loss of its efficiency. © 2013 Elsevier Ltd. All rights reserved.


Mo L.-P.,Hebei Normal University | Chen H.-L.,Hebei Chemical and Pharmaceutical Vocational Technology College
Journal of the Chinese Chemical Society | Year: 2010

A practical and efficient procedure for the one-pot multicomponent couping of aryl aldehydes, 2-naphthol and cyclic 1,3-dicarbonyl compounds using perchloric acid adsorbed on silica gel (HClO4-SiO2) as a highly efficient, inexpensive, convenient, reusable heterogeneous catalyst under solvent-free conditions has been developed. Various biologically important 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives have been efficiently synthesized in high to excellent yields. The present approach offers several advantages such as shorter reaction times, simple work-up, excellent yields, low cost, and mild reaction conditions. Furthermore, the catalyst can be recovered simply and reused without appreciable loss of its catalytic activity.


Li P.,Hebei Normal University | Ma F.,Hebei Normal University | Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Zhang Z.,Hebei Normal University
Chinese Journal of Chemistry | Year: 2013

A low melting citric acid-urea mixture was found to be a new and effective promoting medium for the environmentally friendly synthesis of 1,8-dioxo-dodecahydroxanthene derivatives by condensation of aromatic aldehydes and cyclic 1,3-dicarbobonyl compounds. This deep eutectic solvent acts as both the reaction medium and catalyst, furnishing xanthenediones in high to excellent yields. Copyright © 2013 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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