Hebei Chemical and Pharmaceutical Vocational Technology College

Hebei, China

Hebei Chemical and Pharmaceutical Vocational Technology College

Hebei, China
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Hao Y.X.,Hebei Chemical and Pharmaceutical Vocational Technology College
Applied Mechanics and Materials | Year: 2014

Taking 7-APCA as raw materials, in a suitable solvent system, to get 7-APCA alkali solution with the alkali reaction. The paper takes p-hydroxyphenyl glycine dane salt as raw material, to made the corresponding reagent in phthalic anhydride. Forming DMF salt of cefprozil by reaction of 7-APCA alkaline solution and the mixed anhydride. The transformation of methanol, water, and water purification to get cefprozil monohydrate. The total yield was 63%. The chemical structure of cefprozil were confirmed by IR, 1h-nmr. Product quality in line with national pharmacopoeia requirements. © (2014) Trans Tech Publications, Switzerland.


Sun Y.M.,Hebei Chemical and Pharmaceutical Vocational Technology College
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2010

To observe the effect of intracerebroventricular injection of rAAV-HIF-1α on hippocampal neuronal apoptosis in a rat model of Alzheimer disease (AD). Thirty-two male SD rats (250-300 g) were randomized into 4 groups (n=8), including the normal control group without any treatment, AD model group with right intracerebroventricular injection of 2 μl Aβ25-35 (10 mg/m1), sham-operated group with right intracerebroventricular injection of 2 μl normal saline, and AD+ rAAV-HIF-1α group with right intracerebroventricular injection of 10 μl rAAV-HIF-1a (1×1012 v.g./m1) one week after Aβ25-35 injection. The rats were sacrificed to detect the expression of HIF-1α and apoptosis of hippocampal neurons 5 weeks after Aβ25-35 or saline injection. Western blotting showed that the expression of HIF-1α was significantly higher in AD+rAAV-HIF-1α group (451.59±34.39) than in normal control group (229.05±41.28) and sham-operated group (216.29±37.08) (P<0.05) without significant difference between the latter two groups. The apoptotic ratio of the hippocampal neurons was significantly higher in AD model group ([19.49±2.59]%) than in normal control group ([5.41±0.75]%) and sham-operated group ([5.28±0.66]%) in (P<0.05), and intracerebroventricular injection of rAAV-HIF-1α resulted in a significant reduction of the apoptotic ratio in the AD rats ([12.07±2.06]%) (P<0.05). Intracerebroventricular injection of rAAV-HIF-1α can inhibit hippocampal neuronal apoptosis in the rat model of AD.


Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Wang P.,Hebei Normal University | Ma F.-P.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Journal of Molecular Liquids | Year: 2014

l-(+)-Tartaric acid-choline chloride based deep eutectic solvent has been found to be an effective promoted medium for Clauson-Kaas reaction of aromatic amines and 2,5-dimethoxytetrahydrofuran. Structurally diverse N-substituted pyrroles were obtained in high to excellent yields under mild conditions. The deep eutectic solvent is inexpensive, non-toxic, reusable and biodegradable. © 2014 Elsevier B.V.


Tian A.,Bohai University | Lin X.,Bohai University | Sun N.,Hebei Chemical and Pharmaceutical Vocational Technology College | Ying J.,Bohai University | And 3 more authors.
Inorganic Chemistry Communications | Year: 2014

A new Keggin-type polyoxometalate (POM)-based compound, [Ag 9(ptz)5][PMoVI 11MoVO 40]·H2O (1) (ptzH = 5-phenyl-1H-tetrazole), was synthesized under hydrothermal conditions. Compound 1 exhibits a 2D layer containing AgI ribbons and hexa-nuclear AgI circles, which are further linked by AgI atoms and [PMoVI 11MoVO40]4 - anions to construct a 3D framework. The electrochemical properties of compound 1 have been investigated. © 2013 Elsevier B.V. All rights reserved.


Ma F.-P.,Hebei Normal University | Cheng G.-T.,Hebei Chemical and Pharmaceutical Vocational Technology College | He Z.-G.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Australian Journal of Chemistry | Year: 2012

A general, efficient and green method for the synthesis of quinoline derivatives via the Friedländer heteroannulation reaction of 2-aminoaryl ketones and α-methylene ketones has been developed, employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as an inexpensive, non-toxic, easily biodegradable reaction medium. The melt acts as both the reaction medium and catalyst, furnishing quinolines in high to excellent yields. © 2012 CSIRO.


Wang G.-Z.,Hebei Chemical and Pharmaceutical Vocational Technology College | Li L.-X.,Hebei Chemical and Pharmaceutical Vocational Technology College | Li Y.-Z.,Hebei Chemical and Pharmaceutical Vocational Technology College | Xue Q.-M.,Tianjin University
Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities | Year: 2010

Bamboo activated carbons were prepared by activating the previously FeSO4 immersed bamboo with CO2 at 850°C. The pore properties of the prepared bamboo activated carbons were characterized by N2 adsorption isotherms. The phenol adsorption properties of the prepared bamboo activated carbons were studied by the thermodynamic and kinetic methods at 25°C. It shows that all the prepared bamboo activated carbons have a higher adsorption capacity and fast adsorption rate for the removal of phenol. Freundlich and Langmuir equations were used to model the adsorption isotherms at equilibrium, and it shows that the Langmuir model fits the experimental data more adequately. The adsorption kinetics was tested with pseudo-first-order and pseudo-second-order models, and the rate constants of adsorption for these two kinetics models were calculated. It was found that the pseudo-second-order kinetic model provides better correlation of the experimental data compared to the pseudo-first-order model. The experimental results prove that the prepared bamboo activated carbon is an effective adsorbent for the removal of phenol from aqueous solution.


Guo R.-Y.,Hebei Normal University | Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Wang G.-D.,Hebei Normal University | Mo L.-P.,Hebei Normal University | Zhang Z.-H.,Hebei Normal University
Tetrahedron | Year: 2013

A general, efficient, and green method for one-pot synthesis of functionalized spirooxindoles through three-component condensation reaction of isatins, cyclohexane-1,3-diones, and barbituric acids is described employing gluconic acid aqueous solution (GAAS) as a novel reaction medium and catalyst. The reaction medium could be recycled and reused several times without significant loss of its efficiency. © 2013 Elsevier Ltd. All rights reserved.


Liu Y.-H.,Hebei Medical University | Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Cheng G.-T.,Hebei Chemical and Pharmaceutical Vocational Technology College
Monatshefte fur Chemie | Year: 2013

A general and simple procedure was developed for the synthesis of β-enaminones and β-enamino esters by reacting 1,3-dicarbonyl compounds with amines in the presence of catalytic amounts of niobium pentachloride. The reaction proceeds smoothly at room temperature under solvent-free conditions and leads to chemo- and regioselective formation of enamine derivatives in high to excellent yields. © 2012 Springer-Verlag.


Mo L.-P.,Hebei Normal University | Chen H.-L.,Hebei Chemical and Pharmaceutical Vocational Technology College
Journal of the Chinese Chemical Society | Year: 2010

A practical and efficient procedure for the one-pot multicomponent couping of aryl aldehydes, 2-naphthol and cyclic 1,3-dicarbonyl compounds using perchloric acid adsorbed on silica gel (HClO4-SiO2) as a highly efficient, inexpensive, convenient, reusable heterogeneous catalyst under solvent-free conditions has been developed. Various biologically important 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives have been efficiently synthesized in high to excellent yields. The present approach offers several advantages such as shorter reaction times, simple work-up, excellent yields, low cost, and mild reaction conditions. Furthermore, the catalyst can be recovered simply and reused without appreciable loss of its catalytic activity.


Li P.,Hebei Normal University | Ma F.,Hebei Normal University | Wang P.,Hebei Chemical and Pharmaceutical Vocational Technology College | Zhang Z.,Hebei Normal University
Chinese Journal of Chemistry | Year: 2013

A low melting citric acid-urea mixture was found to be a new and effective promoting medium for the environmentally friendly synthesis of 1,8-dioxo-dodecahydroxanthene derivatives by condensation of aromatic aldehydes and cyclic 1,3-dicarbobonyl compounds. This deep eutectic solvent acts as both the reaction medium and catalyst, furnishing xanthenediones in high to excellent yields. Copyright © 2013 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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