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Zhang R.,Heart Failure Center Fuwai Hospital | Zhang Y.,Heart Failure Center Fuwai Hospital | Zhang J.,Heart Failure Center Fuwai Hospital | An T.,Heart Failure Center Fuwai Hospital | And 10 more authors.
PLoS ONE | Year: 2014

Background: sST2 has been shown to be a risk predictor in heart failure (HF). Our aim was to explore the characteristics and prognostic value of soluble ST2 (sST2) in hospitalized Chinese patients with HF.Methods and Results: We consecutively enrolled 1528 hospitalized patients with HF. Receiver operating characteristic (ROC) and multivariable Cox proportional hazards analysis were used to assess the prognostic values of sST2. Adverse events were defined as all-cause death and cardiac transplantation. During a median follow-up of 19.1 months, 325 patients experienced adverse events. Compared with patients free of events, sST2 concentrations were significantly higher in patients with events (P<0.001). Univariable and multivariable Cox regression analyses showed sST2 concentrations were significantly associated with adverse events (per 1 log unit, adjusted hazard ratio 1.52, 95% confidence interval: 1.30 to 1.78, P<0.001). An sST2 concentration in the highest quartiles (>55.6 ng/mL) independently predicted events in comparison to the lowest quartile (≤25.2 ng/mL) when adjusted by multivariable model. In ROC analysis, the area under the curve for sST2 was not different from that for NT-proBNP in short and longer term. Over time, sST2 also improved discrimination and reclassification of risk beyond NT-proBNP.Conclusions: sST2 is a strong independent risk predictor in Chinese patients hospitalized with HF and can significantly provide additional prognostic value to NT-proBNP in risk prediction. © 2014 Zhang et al.


Zhang R.,Heart Failure Center Fuwai Hospital | Zhang Y.,Heart Failure Center Fuwai Hospital | Zhang J.,Heart Failure Center Fuwai Hospital | Huang Y.,Heart Failure Center Fuwai Hospital | And 6 more authors.
Chinese Journal of Cardiology | Year: 2014

Objective: To explore the predict value of plasma soluble ST2 (sST2) on one-year mortality for hospitalized patients with chronic heart failure (HF).Methods: A total of 1 244 consecutive hospitalized patients admitted to Heart Failure Center Fuwai Hospital between March 2009 and July 2012 and with HF as their primary diagnosis were included. Plasma sST2 was measured in all patients and patients were followed up for 1 year, and the primary endpoint was defined as all-cause death.Results: There were 193 deaths during follow up. sST2 concentrations at admission were positively correlated with NT-proBNP, NYHA functional class and heart rate, and negatively correlated with left ventricular ejection fraction, blood sodium, total cholesterol and glomerular filtration rate at admission. sST2 concentrations were significantly higher in non-survivors compared with survivors (P <0. 001). Multivariate Cox regression analyses showed that sST2 independently predicted 1-year mortality (per 1 log unit, hazard ratio 1.87, 95% confidence interval: 1. 56 to 2. 25, P < 0. 001). In receiver operating characteristic analyses, the area under the curve for ST2 was 0. 776 which was similar to that of N-terminal pro-B-type natriuretic peptide (NT-proBNP) (AUG =0. 775). The prognostic value was improved when combining these two biomarkers together (AUC = 0. 813).Conclusions: sST2 concentration at admission is correlated with clinical and biochemical indexes and associated with 1-year mortality for hospitalized patients with HF.

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