Entity

Time filter

Source Type

Hasselt, Belgium

Hansen D.,Hasselt University | Dendale P.,Heart Center Hasselt
Journal of Cardiopulmonary Rehabilitation and Prevention | Year: 2014

PURPOSE: Type 2 diabetes mellitus (T2DM) is associated with chronotropic incompetence (CI), which may lead to a worse prognosis. It remains uncertain whether CI in T2DM patients is related to patient characteristics that are modifiable by exercise interventions. METHODS: From 33 male T2DM patients and 18 healthy subjects not taking β-blockers, calcium-antagonists, and/or diuretics, a fasting blood sample was collected, followed by an oral glucose tolerance test, maximal cardiopulmonary exercise test, and body composition analysis. Chronotropic incompetence was defined as the inability to achieve a maximal chronotropic response index (maxCRI) ≥ 0.80 during exercise testing. By univariate correlations and multivariate regression analysis, relationships between exercise tolerance, body composition, glycemic control, and maxCRI were examined. RESULTS: MaxCRI was significantly lower in T2DM patients (0.85 ± 0.17) vs healthy controls (1.02 ± 0.17, P <.01): Chronotropic incompetence was prevalent in 14 T2DM patients (42%) and 1 healthy subject (6%, P <.05). Significant (P <.05) univariate correlations between maxCRI and body mass index (r =-0.59), blood high-density lipoprotein cholesterol (r = 0.34), HbA1c (r =-0.33) and insulin level (r =-0.48), HOMA-IR index (r =-0.45), trunk adipose tissue mass (r =-0.45), waist circumference (r =-0.58), peak cycling power output (r = 0.42), and oxygen uptake (r = 0.33) were found (P <.05). Independent significant relations were found between maxCRI and waist circumference (P <.01) and peak cycling power output (P <.05). CONCLUSIONS: Chronotropic incompetence in male T2DM patients is independently related to exercise tolerance and adipose tissue mass. These data provide further insight into the etiology of CI in male T2DM patients and show that exercise interventions might impact predictors of CI. Copyright © 2014 Wolters Kluwer Health | Lippincott Williams &Wilkins. Source


In subjects with obesity, the implementation of long-term exercise intervention increases lean tissue mass and lowers adipose tissue mass. However, data indicate a blunted lipolytic response, and/or skeletal muscle protein synthesis, when subjects with obesity are exposed to acute endurance or resistance exercise, respectively. Therefore, subjects with obesity seem to display a suboptimal physiological response to acute exercise stimuli. It might be hypothesized that hormonal disturbances contribute, at least in part, to these abnormal physiological reactions in the obese. This review discusses the impact of acute endurance and resistance exercise on endocrine hormones directly related to lipolysis and/or skeletal muscle protein synthesis (insulin, [nor]epinephrine, cortisol, growth hormone, testosterone, triiodothyronine, atrial natriuretic peptide, insulin-like growth factor-1), as well as the impact of long-term endurance and resistance exercise intervention on these hormonal responses to acute endurance and resistance exercise. In the obese, some endocrinological disturbances during acute endurance and resistance exercise have been identified: a blunted blood growth hormone, atrial natriuretic peptide and epinephrine release, and greater cortisol and insulin release. These hormonal disturbances might contribute to a suppressed lipolytic response, and/or suppressed skeletal muscle protein synthesis, as a result of acute endurance or resistance exercise, respectively. In subjects with obesity, the impact of acute endurance and resistance exercise on other endocrine hormones (norepinephrine, testosterone, triiodothyronine, insulin-like growth factor-1) remains elusive. Furthermore, whether long-term endurance and resistance exercise intervention might reverse these hormonal disturbances during acute endurance and resistance exercise in these individuals remains unknown. Source


Hansen D.,Hasselt University | Hansen D.,Heart Center Hasselt | Marinus N.,Hasselt University | Remans M.,Hasselt University | And 5 more authors.
Obesity Reviews | Year: 2014

To prescribe feasible and medically safe exercise interventions for obese adolescents, it remains to be determined whether exercise tolerance is altered and whether anomalous cardiopulmonary responses during maximal exercise testing are present. Studies that examined cardiopulmonary responses to maximal exercise testing in obese adolescents were searched: cardiopulmonary exercise tests with respiratory gas exchange measurements of peak oxygen uptake (VO2peak) were performed and comparisons between obese and lean adolescents were made. Study quality was assessed using a standardized item list. By meta-analyses VO2peak, peak cycling power output (Wpeak) and peak heart rate (HRpeak) were compared between groups. Nine articles were selected (333 obese vs. 145 lean adolescents). VO2peak (Lmin-1), HRpeak and Wpeak were not different between groups (P≥0.10), while a trend was found for a reduced VO2peak (mLmin-1kg-1 lean tissue mass) (P=0.07) in obese vs. lean adolescents. It remained uncertain whether anomalous cardiopulmonary responses occur during maximal exercise testing in obese adolescents. In conclusion, a trend was found for lowered VO2peak (mLmin-1kg-1 lean tissue mass) in obese vs. lean adolescents. Whether cardiopulmonary anomalies during maximal exercise testing would occur in obese adolescents remains uncertain. Studies are therefore warranted to examine the cardiopulmonary response during maximal exercise testing in obese adolescents. © 2014 The Authors. obesity reviews © 2014 World Obesity. Source


Efendi A.,Catholic University of Leuven | Molenberghs G.,Catholic University of Leuven | Molenberghs G.,Hasselt University | Njagi E.N.,Hasselt University | Dendale P.,Heart Center Hasselt
Biometrical Journal | Year: 2013

Joint modeling of various longitudinal sequences has received quite a bit of attention in recent times. This paper proposes a so-called marginalized joint model for longitudinal continuous and repeated time-to-event outcomes on the one hand and a marginalized joint model for bivariate repeated time-to-event outcomes on the other. The model has several appealing features. It flexibly allows for association among measurements of the same outcome at different occasions as well as among measurements on different outcomes recorded at the same time. The model also accommodates overdispersion. The time-to-event outcomes are allowed to be censored. While the model builds upon the generalized linear mixed model framework, it is such that model parameters enjoy a direct marginal interpretation. All of these features have been considered before, but here we bring them together in a unified, flexible framework. The model framework's properties are scrutinized using a simulation study. The models are applied to data from a chronic heart failure study and to a so-called comet assay, encountered in preclinical research. Almost surprisingly, the models can be fitted relatively easily using standard statistical software. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Hansen D.,Heart Center Hasselt | Hansen D.,Hasselt University | Meeusen R.,Vrije Universiteit Brussel | Mullens A.,Jessa Hospital | And 2 more authors.
Sports Medicine | Year: 2012

In subjects with obesity, the implementation of long-term exercise intervention increases lean tissue mass and lowers adipose tissue mass. However, data indicate a blunted lipolytic response, andor skeletal muscle protein synthesis, when subjects with obesity are exposed to acute endurance or resistance exercise, respectively. Therefore, subjects with obesity seem to display a suboptimal physiological response to acute exercise stimuli. It might be hypothesized that hormonal disturbances contribute, at least in part, to these abnormal physiological reactions in the obese. This review discusses the impact of acute endurance and resistance exercise on endocrine hormones directly related to lipolysis andor skeletal muscle protein synthesis (insulin, norepinephrine, cortisol, growth hormone, testosterone, triiodothyronine, atrial natriuretic peptide, insulin-like growth factor-1), as well as the impact of long-term endurance and resistance exercise intervention on these hormonal responses to acute endurance and resistance exercise. In the obese, some endocrinological disturbances during acute endurance and resistance exercise have been identified: a blunted blood growth hormone, atrial natriuretic peptide and epinephrine release, and greater cortisol and insulin release. These hormonal disturbances might contribute to a suppressed lipolytic response, andor suppressed skeletal muscle protein synthesis, as a result of acute endurance or resistance exercise, respectively. In subjects with obesity, the impact of acute endurance and resistance exercise on other endocrine hormones (norepinephrine, testosterone, triiodothyronine, insulin-like growth factor-1) remains elusive. Furthermore, whether long-term endurance and resistance exercise intervention might reverse these hormonal disturbances during acute endurance and resistance exercise in these individuals remains unknown. © 2012 Springer International Publishing AG. All rights reserved. Source

Discover hidden collaborations