Health Sciences University of Hokkaido

www.hoku-iryo-u.ac.jp
Kanazawa-shi, Japan

The Health science University of Hokkaido is a private university in Tobetsu, Hokkaido, Japan, established in 1974. The president is Norio Niikawa. Wikipedia.

SEARCH FILTERS
Time filter
Source Type

Okamoto N.,Hiroshima International University | Ishikura M.,Health Sciences University of Hokkaido | Yanada R.,Hiroshima International University
Organic Letters | Year: 2013

A new cleavage reaction of carbon-carbon triple bonds proceeds efficiently with NIS and TMSN3, giving the corresponding nitriles in moderate to good yields. © 2013 American Chemical Society.


Sakuma K.,Toyohashi University of Technology | Yamaguchi A.,Health Sciences University of Hokkaido
Journal of Cachexia, Sarcopenia and Muscle | Year: 2012

Recent advances in our understanding of the biology of muscle, and how anabolic and catabolic stimuli interact to control muscle mass and function, have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle occurs as a consequence of several chronic diseases (cachexia) as well as normal aging (sarcopenia). Although many negative regulators [Atrogin-1, muscle ring finger-1, nuclear factor-kappaB (NF-κB), myostatin, etc.] have been proposed to enhance protein degradation during both sarcopenia and cachexia, the adaptation of mediators markedly differs among these conditions. Sarcopenic and cachectic muscles have been demonstrated to be abundant in myostatin- and apoptosislinked molecules. The ubiquitin-proteasome system (UPS) is activated during many different types of cachexia (cancer cachexia, cardiac heart failure, chronic obstructive pulmonary disease), but not many mediators of the UPS change during sarcopenia. NF-κB signaling is activated in cachectic, but not in sarcopenic, muscle. Some studies have indicated a change of autophagic signaling during both sarcopenia and cachexia, but the adaptation remains to be elucidated. This review provides an overview of the adaptive changes in negative regulators of muscle mass in both sarcopenia and cachexia. © The Author(s) 2012.


Ishikura M.,Health Sciences University of Hokkaido
Heterocycles | Year: 2011

This account deals with our investigation of the reaction and synthetic use of indolylborates as versatile synthetic tools; 1) palladium-catalyzed cross-coupling reaction and its use for the synthesis of indole alkaloids and 2) intramolecular alkylmigration in indolylbotrates for the construction of highly elaborate indole derivatives. © The Japan Institute of Heterocyclic Chemistry.


Ishikura M.,Health Sciences University of Hokkaido
Natural product reports | Year: 2013

Covering: 2010-2011. Previous review: Nat. Prod. Rep. 2010, 27, 1630-1680This review covers the literature on simple indole alkaloids and those with a non-rearranged monoterpenoid unit from the beginning of 2010 up to the end of 2011, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities.


Hashimoto M.,Health Sciences University of Hokkaido
Journal of Biomedical Materials Research - Part B Applied Biomaterials | Year: 2010

Resin adhesion to dentin was first achieved in 1982 through mechanical hybridization between resin and collagen fibrils using an adhesive resin containing a functional monomer. Over the last 2 decades, newly developed adhesive resins have attempted to improve the bond strength at least in the first 24 h after bonding. Although much is known about the initial bond strength, learned through morphological analysis, the long-term durability of bonds has not yet been established analytically. However, numerous recent studies have shown chemical biodegradation of resin-dentin bonds under various testing regimes. In general, studies have shown that dentin bond strength decreases over time due to degradation of the resin and the collagen fibrils within the bonds. Furthermore, crystal formation around cured bonding resins has been reported in a number of adhesives after long-term water storage. However, the extent and process of degradation or crystallization is adhesive type specific. This review mainly summarizes the most recent and state of the art work in degradation of the bonding of dental restorative compounds with dentin based on micromorphological data of scanning and transmission electron microscopy. © 2009 Wiley Periodicals, Inc.


Mori M.,Health Sciences University of Hokkaido
Materials | Year: 2010

Olefin metathesis using ruthenium carbene complexes is a useful method in synthetic organic chemistry. Enyne metathesis is also catalyzed by these complexes and various carbo- and heterocycles could be synthesized from the corresponding enynes. Dienyne metathesis, cross enyne metathesis and ring-opening enyne metathesis have been further developed. Various complicated compounds, such as the natural products and the related biologically active substances, could be synthesized using these metatheses reactions. Skeletal reorganization using the transition metals and metallotropic rearrangement are also discussed.© 2010 by the authors.


Mori M.,Health Sciences University of Hokkaido
Heterocycles | Year: 2010

Strychnine is one of the most famous and complex natural products in its size. Woodward succeeded in the total synthesis of (-)-strychnine in 1954, but there were no other reports of the total synthesis of strychnine for about 40 years. In 1992, Magnus succeeded in the total synthesis of (-)-strychnine and then due to the dramatic progress of synthetic organic chemistry and organometallic chemistry, many researchers tried to synthesize (±)- and (-)-strychnine by their original methods. We developed a novel synthetic method of a chiral cyclohexenyl amine derivative having an aryl group at the 2-posotion by palladium catalyst for the synthesis of (-)-mesembrine. Furthemore, (+)-crinamine, (-)-haemanthidine, and (+)-pretazettine could be synthesized by the same procedure. Modifying this method, the total synthesis of (-)-strychnine was achieved. The chiral cyclohexenyl amine derivative having the sylyloxymethyl group at the 2-position was synthesized using the palladium catalyst. From this comopound, construction of the ABE-rings of (-)-strychnine was carried out. The C-ring was constructed using palladium-catalyzed allylic oxidation. The G-ring and then the F-ring were constructed by intramolecular Heck reaction. All cyclizations for synthesis of (+)-isostrychnine were performed using palladium catalysts. (+)-Isostrychnine was converted into (-)-strychnine by the known method. The progress of the synthesis of a chiral cyclohexenyl amine derivative having the substituent at the 2-position was described. © 2010 The Japan Institute of Heterocyclic Chemistry.


Ishikura M.,Health Sciences University of Hokkaido | Yamada K.,Health Sciences University of Hokkaido | Abe T.,Health Sciences University of Hokkaido
Natural Product Reports | Year: 2010

This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit, and includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. © 2010 The Royal Society of Chemistry.


Patent
Hokkaido University and Health Sciences University of Hokkaido | Date: 2012-05-23

Disclosed is a method for measuring the concentration of a peroxide using a CNT sensor. The CNT sensor comprises a working electrode that is arranged on an insulating substrate, a monolayered carbon nano-tube that is contacted with the working electrode, a counter electrode, and a reference electrode. A sample is provided on the monolayered carbon nano-tube, and a potential difference is made between the working electrode and the counter electrode. In this manner, the concentration of the peroxide in the sample can be measured. The measurement method can be applied to clinical tests or the like.


Patent
Health Sciences University of Hokkaido and Hokkaido University | Date: 2010-07-16

Disclosed is a method for measuring the concentration of a peroxide using a CNT sensor. The CNT sensor comprises a working electrode that is arranged on an insulating substrate, a monolayered carbon nano-tube that is contacted with the working electrode, a counter electrode, and a reference electrode. A sample is provided on the monolayered carbon nano-tube, and a potential difference is made between the working electrode and the counter electrode. In this manner, the concentration of the peroxide in the sample can be measured. The measurement method can be applied to clinical tests or the like.

Loading Health Sciences University of Hokkaido collaborators
Loading Health Sciences University of Hokkaido collaborators