Time filter

Source Type

Rook D.,Erasmus Medical Center | Schierbeek H.,Academic Medical Center Emma Childrens Hospital | Vento M.,Polytechnic University of Valencia | Vento M.,La Fe Health Research Institute | And 9 more authors.
Journal of Pediatrics | Year: 2014

Objective To test the hypothesis that an initial fraction of inspired oxygen (FiO2) of 30% during resuscitation of preterm infants results in less oxidative stress and is associated with improved clinical outcomes compared with an FiO2 of 65%. Study design Preterm infants of gestational age <32 weeks (n = 193) were randomized to start resuscitation with either 30% oxygen (low-oxygen group) or 65% oxygen (high-oxygen group), after which the FiO2 was adjusted based on oxygen saturation values. The primary outcome was bronchopulmonary dysplasia (BPD) assessed at 36 weeks postmenstrual age. Secondary outcomes included major neonatal illnesses and markers of oxidative stress. Results The median gestational age of included infants was 286/7 weeks (IQR, 265/ 7-303/7 weeks). The incidence of BPD was not significantly different between the low-oxygen and high-oxygen groups (24% vs 17%; P =.15). The FiO2 in both groups was adjusted to a mean of 40% by 7 minutes in the low-oxygen group and by 11 minutes in the high-oxygen group. No differences in markers of oxidative stress were noted between groups. Conclusion Initial supplementation of preterm infants with 30% oxygen during the fetal-to-neonatal transition is as safe as 65% oxygen, with no differences in oxidative stress markers or BPD. © 2014 Elsevier Inc. All rights reserved. Source

Marti-Bonmati L.,Polytechnic University of Valencia | Ramirez-Fuentes C.,Polytechnic University of Valencia | Alberich-Bayarri A.,La Fe Health Research Institute | Ruiz-Llorca C.,Polytechnic University of Valencia
Current Opinion in Oncology | Year: 2015

Purpose of review: Multiple myeloma is a common hematological malignancy arising in the bone marrow. Bone lesions were initially depicted with conventional radiography, although recently 18F-FDG PET/CT and MRI are recognized as having a clear role in the initial workup and in the evaluation of therapy response. Recent findings: Tumor development produces osteolysis and expansive lesions. Although tumor burden and extent are key prognostic factors, different cancer hallmarks can also be evaluated in vivo through noninvasive imaging. Summary: This imaging-based virtual biopsy approach might be useful to define several relevant prognostic markers, such as angiogenesis, cellularity, metabolic trapping and bone morphology and elasticity, both before and during treatment, to predict tumor behavior and the early effect of therapy. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

Roque W.L.,Federal University of Paraiba | Alberich-Bayarri A.,La Fe Health Research Institute
Lecture Notes in Computational Vision and Biomechanics | Year: 2015

Osteoporosis is a disease characterized by a remarkable bone mass loss and trabecular bone degradation, which leads to an increase in bone fragility and a higher fracture risk. There are strong evidences that the trabecular microarchitecture degradation impacts the fracture risk. The trabecular bone structure resembles a network composed of tortuous struts and their tortuosity influences the structural stiffness. This work investigates how the trabecular volume fraction, network connectivity, trabecular tortuosity andYoung modulus of elasticity can be aggregated in a unique variable to provide information about the trabecular bone fragility. The parameters are estimated for three cohorts, two from ex vivo microtomographic (μCT) images and the other one from in vivo magnetic resonance imaging (MRI); the μCT image samples are from distal radius and vertebrae, while the MRI samples are also from distal radius. The principal component analysis shows that the principal component, defined as mechanical competence parameter (MCP), can be used to grade the quality of the samples and a visual color spectrum is generated to provide a quality distribution of the samples. The results point out a prevalent direction of the tortuosity along the z direction in all cohorts, which correspond to the most frequent direction of stress and high values of MCP indicating better structured samples. In addition, a remarkable result is the strong correlation between the tortuosity in both x and y horizontal directions and the elasticity in the z vertical direction, evidencing the role that the horizontal trabecular connectivity plays to the mechanical competence of the trabecular bone structure. © Springer International Publishing Switzerland 2015. Source

Discover hidden collaborations