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Tokushima-shi, Japan

Kamemura N.,Tokushima University | Tada H.,Tokushima University | Shimojo N.,Chiba University | Morita Y.,Chiba University | And 6 more authors.
Journal of Allergy and Clinical Immunology

Background: To design a rational allergy prevention program, it is important to determine whether allergic sensitization starts in utero under the maternal immune system. Objective: To investigate the origin of allergen-specific IgE antibodies in cord blood (CB) and maternofetal transfer of immunoglobulins. Methods: The levels of food and inhalant allergen-specific IgE, IgA, IgG, and IgG 4 antibodies in CB and maternal blood (MB) from 92 paired neonates and mothers were measured by using a novel allergen microarray of diamond-like-carbon-coated chip, with high-sensitivity detection of allergen-specific antibodies and allergen profiles. Results: The levels of allergen-specific IgE antibodies against food and inhalant allergens and allergen profiles were identical in CB and newborn blood, but the levels and profiles, specifically against inhalant allergens, were different from those in MB. The level of allergen-specific IgA antibodies was below the detection levels in CB despite clear detection in MB. Therefore, contamination with MB in CB was excluded on the basis of extremely low levels of IgA antibodies in CB and the obvious mismatch of the allergen-specific IgE and IgA profiles between CB and MB. However, the levels of allergen-specific IgG and IgG 4 antibodies and their allergen profiles were almost identical in both MB and CB. Conclusion: Allergen-specific levels of IgE and IgA antibodies and their allergen profiles analyzed by the diamond-like-carbon allergen chip indicate that IgE antibodies in CB are of fetal origin. Food-allergen specific IgE antibodies were detected more often than inhalant-allergen specific IgE antibodies in CB, the reason of which remains unclarified. © 2012 American Academy of Allergy, Asthma & Immunology. Source

Tonogai I.,Health Insurance Naruto Hospital
Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand

We have retrospectively reviewed 17 thumbs in 16 patients with osteoarthritis of the thumb carpometacarpal joints, for which arthroplasty was performed using Kaarela's method. Postoperatively, three thumbs in two patients had poor outcomes; both patients had a sharp slope of the base of the first metacarpal. Serial radiographic measurements suggested that this sharp slope affected the adducted position of the first metacarpal, and led to the appearance of a metacarpophalangeal joint hyperextension deformity of the thumb. This radiological finding could be a prognostic predictor after surgery for osteoarthritis of the thumb carpometacarpal joint. Source

Yoshioka S.,Tokushima University | Hamada Y.,Health Insurance Naruto Hospital | Takata S.,Tokushima University | Takai H.,Anan Central Hospital of the Medical Association | Yasui N.,Tokushima University

We describe a patient in which an osteochondroma, which resulted from hereditary multiple exostoses, limited flexion of the proximal interphalangeal (PIP) joint at birth. The tumor grew over the original distal head of the proximal phalanx, and the early appearance of a second ossification center on the base of the middle phalanx was observed. The mass was removed surgically when the patient was 17 months old. There was an improvement in the range of motion at a follow-up evaluation 3 years later. The tumor shape and the growth of the affected PIP joint are examined in detail. © 2009 American Association for Hand Surgery. Source

Maegawa M.,Tokushima Prefectural Central Hospital | Mitani R.,Tokushima Prefectural Central Hospital | Miyatani Y.,Tokushima Prefectural Central Hospital | Ueta S.,Tokushima University | And 5 more authors.
Reproductive Medicine and Biology

A 27-year-old woman had massive genital bleeding after an artificial abortion. Color Doppler ultrasonography showed a hypervascular mass. Hysteroscopy revealed a placental polyp. Serum hemoglobin level was decreased to 7.7 g/dl. Although uterine artery embolization (UAE) followed by hysteroscopic resection has been used for treatment of a placental polyp, UAE may not be an ideal option for patients with intent for future pregnancy because of the risk of ovarian function failure. This report presents a case of a placental polyp managed successfully with intracervical injection of prostaglandin F 2α, as an alternative UAE, followed by hysteroscopic resection. © Japan Society for Reproductive Medicine 2011. Source

The treatment of old fracture-dislocation of a toe is usually difficult. The authors used 2 techniques that are commonly used in finger operations: One is the pins and rubber band traction system, and the other is the hook plate osteosynthesis. They treated a 56-year-old woman using these methods, and obtained a good result. Source

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