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Muhammad I.,RMIT University | Teoh S.Y.,RMIT University | Wickramasinghe N.,Health Innovations Research Institute
International Journal of E-Health and Medical Communications | Year: 2013

Healthcare systems around the globe are facing a number of challenges. Thus Increasing focus is being placed on constructing appropriate healthcare reforms which are attempting to address how to tackle these challenges. A critical enabler in these reforms is the adoption of an e-health solution. Such e-health solutions are not only expensive and complex endeavours, but also have far reaching implications. Given that the implementation and adoption of these e-health solutions is so important, not to mention also requiring a substantial investment in various resources such as time and money, it is therefore essential to ensure their success. The following proffers a socio-technical analysis as an appropriate strategy to ensure more successful outcomes. An exemplar case study of the Personally Controlled Electronic Health Record (PCEHR), the chosen e-health solution by the Australian government is provided to illustrate the benefits such an analysis might provide. Copyright © 2013, IGI Global.

News Article
Site: www.biosciencetechnology.com

INTEGRA reports on how researchers at the Health Innovation Research Institute at RMIT University (Bundoora, Australia) are using VIAFLO II electronic pipettes in conjunction with a VIAFLO ASSIST to scale-up their screening of venoms and small compounds. The Health Innovations Research Institute (HIRi) is an RMIT University initiative that seeks to address key health issues facing Australia in the 21st century, with research programs that examine how the human body functions at a molecular and cellular level. This research is targeted to provide innovative therapeutic strategies to improve the health and wellbeing of people in Australia and around the world. Bill Darby, a Researcher at HIRi, commented "We approached INTEGRA's Australian distributor (BioTools Pty Ltd.) for a solution to scale-up our screening of venoms and small compounds in both 96- and 384-well plates. Following a demonstration we found that the VIAFLO ASSIST pipetting assistant met our required criteria of a cost effective and easy to use pipetting solution, which lead us to purchase the ASSIST and 3 VIAFLO II multichannel pipettes". Mr Darby added "Since its introduction, the system has been running perfectly and we have been able to achieve the scaling-up we required. The ASSIST has delivered more accurate and precise pipetting results that have improved our assay results. Another significant benefit is that the ASSIST is very compact and easily fits in our lab hood. We have also found that the versatility of the VIAFLO II pipettes has proven especially useful for handling complicated layouts in 384-well plates". INTEGRA Biosciences Corp., 603 578 5800, www.integra-bioscience.com

Zhang C.S.,Health Innovations Research Institute | Zhang C.S.,RMIT University | Pannirselvan M.,RMIT University | Xue C.C.,Health Innovations Research Institute | And 2 more authors.
Acupuncture in Medicine | Year: 2014

Background: Most popular single-use acupuncture needles consist of a stainless steel shaft with a handle made of copper coil or plastic stick. Objectives: To determine the strengths and weaknesses of these two handle types for needle buckling. Methods: The buckling load for acupuncture needles with these two different handle types was determined using a digital scale, and the stiffness of stainless steel wires used in different types of acupuncture needles was measured using a Dynamic Mechanical Analysis machine. Results: This study showed that an acupuncture needle with a copper coil handle was far more susceptible to buckling than a needle with a plastic stick handle. The average buckling force of acupuncture needles with plastic stick handles was 46.7% higher than that with copper coil handles for needles of 0.25 mmx30 mm, and 30.8% higher for needles of 0.25 mmx60 mm. Replacing a copper coil handle with a plastic stick handle could save about 100 tonnes of copper wires and 20 million metres of medical grade stainless steel wire a year worldwide. Conclusions: The results from this study suggest that the common practice of using coiled copper for handles on acupuncture needles should be re-evaluated. Replacing a copper coil handle with a plastic stick handle would significantly reduce needle buckling and improve patient comfort and safety. This would also reduce the consumption of copper and medical grade stainless steel wire considerably. © 2014, BMJ Publishing Group. All rights reserved.

Abbiss C.R.,Edith Cowan University | Abbiss C.R.,Australian Institute of Sport | Abbiss C.R.,Commonwealth Scientific and Industrial Research Organization | Karagounis L.G.,Health Innovations Research Institute | And 7 more authors.
Journal of Applied Physiology | Year: 2011

Single-leg cycling may enhance the peripheral adaptations of skeletal muscle to a greater extent than double-leg cycling. The purpose of the current study was to determine the influence of 3 wk of high-intensity single-and double-leg cycle training on markers of oxidative potential and muscle metabolism and exercise performance. In a crossover design, nine trained cyclists (78 ± 7 kg body wt, 59 ± 5 ml kg-1 min -1 maximal O2 consumption) performed an incremental cycling test and a 16-km cycling time trial before and after 3 wk of double-leg and counterweighted single-leg cycle training (2 training sessions per week). Training involved three (double) or six (single) maximal 4-min intervals with 6 min of recovery. Mean power output during the single-leg intervals was more than half that during the double-leg intervals (198 ± 29 vs. 344 ± 38 W, P < 0.05). Skeletal muscle biopsy samples from the vastus lateralis revealed a training-induced increase in Thr172-phosphorylated 5′-AMP-activated protein kinase α-subunit for both groups (P < 0.05). However, the increase in cytochrome c oxidase subunits II and IV and GLUT-4 protein concentration was greater following single-than double-leg cycling (P < 0.05). Training-induced improvements in maximal O2 consumption (3.9 ± 6.2% vs. 0.6 ± 3.6%) and time-trial performance (1.3 ± 0.5% vs. 2.3 ± 4.2%) were similar following both interventions. We conclude that short-term high-intensity single-leg cycle training can elicit greater enhancement in the metabolic and oxidative potential of skeletal muscle than traditional double-leg cycling. Single-leg cycling may therefore provide a valuable training stimulus for trained and clinical populations. © 2011 the American Physiological Society.

Todorova N.,Health Innovations Research Institute | Makarucha A.J.,Health Innovations Research Institute | Hine N.D.M.,Imperial College London | Mostofi A.A.,Imperial College London | Yarovsky I.,Health Innovations Research Institute
PLoS Computational Biology | Year: 2013

Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and fibril formation of amyloid-prone proteins. We employ classical molecular dynamics simulations and large-scale density functional theory calculations to investigate the effects of nanomaterials on the structure, dynamics and binding of an amyloidogenic peptide apoC-II(60-70). We show that the binding affinity of this peptide to carbonaceous nanomaterials such as C60, nanotubes and graphene decreases with increasing nanoparticle curvature. Strong binding is facilitated by the large contact area available for π-stacking between the aromatic residues of the peptide and the extended surfaces of graphene and the nanotube. The highly curved fullerene surface exhibits reduced efficiency for π-stacking but promotes increased peptide dynamics. We postulate that the increase in conformational dynamics of the amyloid peptide can be unfavorable for the formation of fibril competent structures. In contrast, extended fibril forming peptide conformations are promoted by the nanotube and graphene surfaces which can provide a template for fibril-growth. © 2013 Todorova et al.

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