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Bells Corners, Canada

Mawas F.,UK National Institute for Biological Standards and Control | Burkin K.,UK National Institute for Biological Standards and Control | Dougall T.,UK National Institute for Biological Standards and Control | Saydam M.,UK National Institute for Biological Standards and Control | And 79 more authors.
Biologicals | Year: 2015

In this report we present the results of a collaborative study for the preparation and calibration of a replacement International Standard (IS) for Haemophilus influenzae type b polysaccharide (polyribosyl ribitol phosphate; 5-. d-ribitol-(1 → 1)-β-. d-ribose-3-phosphate; PRP). Two candidate preparations were evaluated. Thirteen laboratories from 9 different countries participated in the collaborative study to assess the suitability and determine the PRP content of two candidate standards. On the basis of the results from this study, Candidate 2 (NIBSC code 12/306) has been established as the 2nd WHO IS for PRP by the Expert Committee of Biological Standards of the World Health Organisation with a content of 4.904 ± 0.185. mg/ampoule, as determined by the ribose assays carried out by 11 of the participating laboratories. © 2015 The International Alliance for Biological Standardization.

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