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Tuncel N.,Haydarpasa Numune Research and Teaching Hospital | Tuncel H.,Istanbul University | Bayrak I.,Istanbul University | Gunes P.,Haydarpasa Numune Research and Teaching Hospital | Uzunismail M.A.,Haydarpasa Numune Research and Teaching Hospital
Journal of the College of Physicians and Surgeons Pakistan | Year: 2012

Objective: To determine the cellular effects of providing a fascial interface around subcutaneously-placed silicone implants, in terms of capsule thickness, myofibroblast/fibroblast cell count and inflammatory cell count. Study Design: Interventional, comparative study. Place and Duration of Study: Istanbul University Cerrahpasa Medical Faculty, Laboratory of Experimental Animals, Istanbul, Turkey, from May to September 2008. Methodology: A total of 16 adult New Zealand male rabbits with mean weight of 2508 ± 360 g were used in the study. Animals were divided into two groups as experiment and control groups with equal number of rabbits in each. Fascia injection was applied on silicone implant in the experiment group and compared with the control group in terms of capsule thickness, myofibroblast/fibroblast cell count and inflammatory cell count. At the end of the experiment, tissue samples were examined macroscopically and microscopically for the above. Statistical analysis of data was performed using student's t-test. Results: A statistically significant difference was found between experiment group and control group in terms of mean capsule thickness, mean myofibroblast and fibroblast cell counts and cell density (p < 0.05, each). Conclusion: Fascia tissue barrier prevent silicone rod reaction and foreign body reaction developing against silicone prosthesis in the studied animal model. Source

Kayatas K.,Haydarpasa Numune Research and Teaching Hospital | Sahin G.,Haydarpasa Numune Research and Teaching Hospital | Tepe M.,Haydarpasa Numune Research and Teaching Hospital | Kaya Z.E.,Haydarpasa Numune Research and Teaching Hospital | And 2 more authors.
Renal Failure | Year: 2014

Objective: We aimed to evaluate acute kidney injury (AKI), occurrence of recovery and risk factors associated with permanent kidney injury and mortality in the elderly individuals. Design: Evidence for this study was obtained from retrospective cohort study from our center. Patients: A total of 193 patients (>65 years, mean age: 79.99 ± 6.93) with acute kidney injury were enrolled in this study between 2011 and 2012. Patients with kidney failure or renal replacement therapy (RRT) history at admission were excluded. Intervention: Main outcome measurements: serum creatinine (SCr), estimated GFR (with CKD-Epi) and complete blood counts were evaluated at baseline and daily basis thereafter. The AKI was defined based on Kidney Disease Improving Global Outcomes (KDIGO) classification. Results: Among 193 patients, 43 (22%) patients required RRT. Mortality rate was 18% (n = 36) SCr levels were restored within 9.9 ± 6.7days on average (8-39 days). Sixteen patients (12.7%) required RRT after discharge. The mean hospital stay was 10.1 ± 8.6 days (7-41 days). Mortality rate of patients who have no renal recovery was higher (44.8% vs. 4.8%) than renal recovery group (p < 0.01). Conclusion: The AKI represents a frequent complication in the elderly patients with longer hospital stay and increased mortality and morbidity. Our results show that dialytic support requirement is an independent predictor of permeant kidney injury in the elderly AKI patients. Older age, low diastolic blood pressure, high CRP and low hemoglobin levels were independent risk factors for mortality. © 2014 Informa Healthcare USA, Inc. All rights reserved. Source

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