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Liu J.,CAS Kunming Institute of Botany | Zhang X.,CAS Kunming Institute of Botany | Shi Y.,Hawley and Hazel Chemical ZS Co. | Jiang Z.,CAS Kunming Institute of Botany | And 2 more authors.
Zhongguo Zhongyao Zazhi | Year: 2010

Objective: To study the chemical constituents of Illicium henryi. Method: Column chromatographic techniques using silica gel, Sephadex LH-20, Rp-8 and Rp-18 as packing materials were applied to isolate constituents. The structures of isolates were determined on the basis of spectroscopic data analyses. Result: Twelve compounds were isolated from the rhizomes of I. henryi, which were characterized as balanophonin (1), aviculin (2), rubriflosides A (3), 1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol (4), jasopyran (5), kaempferol (6), quercetin (7), (2R, 3R)-3, 5, 7, 3′, 5′- pentahydroxyflavan (8),3,4, 5-trimethoxyphenyl-1-O-β-D-glucopyranoside (9), 3, 4-dimethoxyphenyl-1-O-β-D-glucopyranoside (10), coniferyl aldehyde (11), sinapaldehyde (12), respectively. Conclusion: All the isolates were obtained for the first time from this plant. Source


Liu J.-F.,CAS Kunming Institute of Botany | Liu J.-F.,University of Chinese Academy of Sciences | Jiang Z.-Y.,CAS Kunming Institute of Botany | Zhang Q.,CAS Kunming Institute of Botany | And 6 more authors.
Planta Medica | Year: 2010

Five new sesquiterpene lactones, henrylactones AE (15), together with ten known compounds: cycloparvifloralone (6), tashironin (7), tashironin A (8), neoanisatin (9), anisatin (10), anislactone B (11), 7-O-acetylanislactone B (12), merrillianolide (13), cyclomerrillianolide (14) and pseudomajucin (15), were isolated from the stems and roots of Illicium henryi. Their structures were elucidated based on extensive spectroscopic data analyses. Among them, henrylactone A (1) is a novel sesquiterpene with a dilactone moiety and its structure was confirmed by Xray diffraction. Sesquiterpene lactones 115 were tested for their anti-hepatitis B virus (HBV) activities. The most active compound, tashironin (7), exhibited an IC50 value of 0.48mM (SI=6.3) inhibiting on HBV surface antigen (HBsAg) secretion and an IC50 value of 0.15mM (SI=20.1) inhibiting on HBV e antigen (HBeAg) secretion using HBV transfected Hep G2.2.15 cell line. © Georg Thieme Verlag KG Stuttgart New York. Source


Liu J.-F.,CAS Kunming Institute of Botany | Liu J.-F.,University of Chinese Academy of Sciences | Jiang Z.-Y.,CAS Kunming Institute of Botany | Geng C.-A.,CAS Kunming Institute of Botany | And 7 more authors.
Chemistry and Biodiversity | Year: 2011

Two new lignans, dihydrodehydrodiconiferyl alcohol 9-O-β-D-(3′- O-acetyl)-xylopyranoside (1) and threo-4,9,9′-trihydroxy-3,3′- dimethoxy-8-O-4′-neolignan 7-O-α-rhamnopyranoside (2) were isolated from Illicium henryi, together with ten known compounds, 3-12. Their structures were elucidated by extensive spectroscopic analyses. The anti-hepatitis B virus (anti-HBV) activity of compounds 1-12 inhibiting HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line was evaluated. (-)-Dihydrodehydrodiconiferyl alcohol (4) showed moderate inhibitory activity on both HBsAg and HBeAg secretion with IC50 values of 0.06 and 0.53 mM, respectively. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich. Source


Liu J.-F.,CAS Kunming Institute of Botany | Liu J.-F.,University of Chinese Academy of Sciences | Jiang Z.-Y.,CAS Kunming Institute of Botany | Geng C.-A.,CAS Kunming Institute of Botany | And 6 more authors.
Planta Medica | Year: 2010

Bioassay-guided fractionation of the ethanol extract of the leaves and stems of Illicium simonsii led to the isolation of two new compounds, simonin A (1) and 1-hydroxyl-2-O-D-6-acetyl-glucopyranosyl-4-allylbenzene (2), along with eight known compounds. Their structures were elucidated by spectroscopic analysis. The isolates were tested for anti-oral microbial activity using a microdilution method. Compounds 1 and 36 showed significant activities against oral microbial organisms (Actinomyces viscosus, Streptococcus mutans, Streptococcus sanguis, and Actinomyces naeslundii), with minimum inhibitory concentration (MIC) values ranging from 1.95 to 31.25μ g/mL in vitro. © 2010 Georg Thieme Verlag KG Stuttgart · New York. Source

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