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Ulusoy S.,Karadeniz Technical University | Ozkan G.,Hatay Antakya State Hospital | Sonmez M.,Karadeniz Technical University | Mungan S.,Karadeniz Technical University | And 3 more authors.
Journal of Nippon Medical School | Year: 2015

In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3.5 years. These characteristics make our case the first to be reported in the literature. © 2015, Medical Association of Nippon Medical School. All rights reserved.

Ekiz F.,Hatay Antakya State Hospital | Yuksel I.,Yildirim Beyazit University | Arikok A.T.,Diskapi Yildirim Beyazit Educational and Research Hospital | Yilmaz B.,Osmaniye State Hospital | And 6 more authors.
Hepatology International | Year: 2015

Background and aim: Liver biopsy is the gold standard for assessment of fibrosis in patients with hepatitis B. However, it has some disadvantages, including inter-observer and intra-observer variability in biopsy interpretation and specimen variation. A standard biopsy specimen represents only about 0.0002 % of the whole liver. It has been shown that two biopsy samples collected during a procedure have significant influence on the diagnostic performance of interpretation in patients with hepatitis C or non-alcoholic steatohepatitis. Therefore, we aimed to assess the influence of collecting two liver biopsy samples during a single procedure for staging and grading chronic hepatitis B. Patients and methods: 27 patients were included in the study. The median age of the patients was 43.51 ± 11.69. Fifteen patients were female, 12 patients were male. In the biopsy procedure, two samples of liver lobes were obtained. Grade and stage scores were compared between the two samples. Fibrosis staging and grading were assessed according to the Ishak scoring system. Results: Numbers of portal tract and biopsy size were equal in the two samples. There was a significant difference between the samples in terms of histological activity index (p value = 0.04). However, the difference was not enough to distinguish the mild and moderate stages. On the other hand, no significant difference in fibrosis staging between the two samples was found. Conclusions: With this relatively small size of patients, in this study, we showed that a proper liver biopsy size is sufficient to predict treatment decisions in chronic hepatitis B patients. However, further studies are needed to show the association of sampling variability in patients with hepatitis B. © 2015 Asian Pacific Association for the Study of the Liver

Ozkan G.,Hatay Antakya State Hospital | Ulusoy S.,Karadeniz Technical University
International Journal of Clinical and Experimental Medicine | Year: 2015

Chronic kidney disease continues to represent a significant health problem in all societies. One of the main factors accelerating renal progression is nephrotoxins. The African mango is a plant added to many foods and commonly consumed in West Africa. No toxic effect has to date been shown. Our aim was to discuss the 42-year-old patient who became dialysis-dependent through developing rapid renal progression following 2.5-month African mango use. To the best of our knowledge, our patient is the first case of chronic renal insufficiency developing in association with African mango consumption. © 2015 E-Century Publishing Corporation. All rights reserved.

Erdis E.,Hatay Antakya State Hospital
Journal of the Pakistan Medical Association | Year: 2014

Cervical cancer is a frequent malignancy of the females. It still remains a leading cause of cancerrelated death in women world wide. Cervical cancers do not always spread, but those that do most often spread to the lungs, liver, bladder, and vagina. We report a 67-year-old woman with squamous cell carcinoma of cervix that could not receive chemoradio therapy due to mesenteric involvement. A 25 mm mass was detected in the magnetic resonance examination which was performed due to persistent headache. Diffusion magnetic resonance revealed non-contrasted mass consistent with metastases. The patient received palliative radiotherapy at 3000 cGy. Brain scans can be beneficial for metastasis detection if there is presence of significant symptoms at cervical cancer.

Ozkan G.,Hatay Antakya State Hospital | Ulusoy S.,Karadeniz Technical University | Mentese A.,Karadeniz Technical University | Guvercin B.,Karadeniz Technical University | And 4 more authors.
Clinical Biochemistry | Year: 2015

Background: Cardiovascular (CV) mortality is common in hemodialysis (HD) patients. There are some difficulties involved in determining CV risk. Galectin-3 is a molecule with a demonstrated correlation with CV mortality and which is approved in the stratification of heart failure (HF) risk. The purpose of this study was to assess the previously uninvestigated relationship between galectin-3 and cardiac mortality in HD patients. Methods: Two hundred ninety clinically stable HD patients aged over 18 and on a thrice-weekly intermittent HD program lasting >. 3. months and 30 healthy individuals were enrolled in this multi-center, prospective, observational study and monitored over 24. months. Blood specimens were collected at the start of the study for the measurement of galectin-3 and other biochemical parameters. At the end of the study, the relations between galectin-3 and other biochemical and demographic parameters and mortality were analyzed. Results: Galectin-3 levels were significantly higher in the HD group compared to the control group (p. <. 0.001). All-cause mortality was observed in 63 (21%) patients. At multivariate Cox regression analysis, age, low albumin, low DBP, high galectin-3 and high HsCRP were identified as prognostic determinants of all-cause mortality, while age, low albumin, high galectin-3 and high SBP were identified as prognostic determinants of cardiac mortality. Conclusion: This study shows, for the first time in the literature, that galectin-3 may be a novel biomarker of cardiac mortality in HD patients. We think that, when supported by further studies, galectin-3 can be a promising biomarker in predicting cardiac mortality in HD patients. © 2015 The Canadian Society of Clinical Chemists.

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