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Hata, Japan

Takagi H.,Hata General Hospital | Miyairi J.,Hata General Hospital | Hata M.,Hata General Hospital | Kirii Y.,Hata General Hospital | Tsuchiya S.,Nippon Medical School
Breast Cancer | Year: 2013

Pseudoangiomatous stromal hyperplasia (PASH), characterized by the presence of slit-like spaces embedded in a hyalinized stroma, is sometimes observed during pathologic examination of breast-tissue specimens. Because tumor-forming PASH is rare, we report a case of a 41-year-old woman admitted to our hospital with a tumor in her left breast. Ultrasonography and aspiration biopsy cytology revealed a benign tumor. After performing Mammotome® biopsy, the lesion was diagnosed as PASH of the breast based on characteristic findings of histology and immunohistochemical studies. Because PASH tumors do not usually become malignant, we decided to perform ultrasonographic follow-up without tumor excision. © 2010 The Japanese Breast Cancer Society. Source


Kirii Y.,Hata General Hospital | Ichikawa C.,Hata General Hospital | Miyamoto M.,Hata General Hospital | Hata M.,Hata General Hospital | And 4 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2010

Large cell neuroendocrine carcinoma (LCNEC) is a relatively new category with biological behavior similar to small cell carcinoma. Thus, it is reportedly well treated by the same chemotherapy as for small cell carcinoma. We experienced a case of gastric large cell neuroendocrine carcinoma, treated very effectively by CDDP+CPT-11.60 mg/m2 of CDDP was administered on day 1, and 60 mg/m2 of CPT-11 on day 1, 8 and 15. An intermission after administration for 14 days made for one course. Four courses were carried out. A complete response was obtained for a primary gastric lesion and liver metastasis, and a partial response was obtained for lymph node metastases. So far it has showed no change for 6 months after chemotherapy. Both CDDP and CPT-11 are key drugs in the chemotherapy for common gastric cancer, and it is sometimes difficult to distinguish large cell neuroendocrine carcinoma from poorly-differentiated gastric cancer. We found this combination chemotherapy is a suitable regimen for the assumed existence of large cell neuroendocrine carcinoma at the gastric lesion. Source

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